Human Gut Microbiome – how intestinal bacteria influence our health
DOI:
https://doi.org/10.12775/JEHS.2023.22.01.002Keywords
Gut Microbiome, Intestinal Bacteria, Health and BacteriaAbstract
Introduction: Gut microbiome is composed of hundreds of different bacterial species.Possibly every type of bacteria can affect many different aspects of human healthGut bacterial composition varies immensely between healthy and sick people and there are many factors which can influence micriobiota balance in our intestines.
Aim of study: The purpose of the study was to review the latest literature on the gut bacteria importance and to discover what factors can influence gut microbiome composition.
Matherials and methods: A systemic review was conducted using Google Scholar, PubMed and ScienceDirect databases and the search was limited to studies published between 2000 and 2023. The search strategy was based on following terms: microbiome, gut bacteria, health and microbiome, gut microflora, human intestinal microbiota
Results: We found many different studies which show importance of gut microflora in various different ailments and diseases, we have also found many showing factors that influence intestinal microbiota composition.Conclusions: Gut microbiota is very broad topic – it can affect many different aspects of human health, starting from lowering the risk of developing allergy or affecting weight loss to affecting risk of colorectal cancer development . It can be affected by many different factors – lots of them are still uknown and need further studies.
References
Wang H., Wei C.-X., Min L., Zhu L.-Y. Good or bad: Gut bacteria in human health and diseases. Biotechnol. Biotechnol. Equip. 2018;32:1075–1080. doi: 10.1080/13102818.2018.1481350.
Durack J, Lynch SV. The gut microbiome: Relationships with disease and opportunities for therapy. J Exp Med. 2019;216(1):20-40. doi:10.1084/jem.20180448
Bull MJ, Plummer NT. Part 1: The Human Gut Microbiome in Health and Disease. Integr Med (Encinitas). 2014 Dec;13(6):17-22. PMID: 26770121; PMCID: PMC4566439.
Jandhyala SM, Talukdar R, Subramanyam C, Vuyyuru H, Sasikala M, Nageshwar Reddy D. Role of the normal gut microbiota. World J Gastroenterol. 2015 Aug 7;21(29):8787-803. doi: 10.3748/wjg.v21.i29.8787. PMID: 26269668; PMCID: PMC4528021.
Ursell LK, Metcalf JL, Parfrey LW, Knight R. Defining the human microbiome. Nutr Rev. 2012 Aug;70 Suppl 1(Suppl 1):S38-44. doi: 10.1111/j.1753-4887.2012.00493.x. PMID: 22861806; PMCID: PMC3426293.
Eckburg P. B., Bik E. M., Bernstein C. N., et al. Microbiology: diversity of the human intestinal microbial flora. Science. 2005;308(5728):1635–1638. doi: 10.1126/science.1110591.
Panthee B, Gyawali S, Panthee P, Techato K. Environmental and Human Microbiome for Health. Life (Basel). 2022 Mar 19;12(3):456. doi: 10.3390/life12030456. PMID: 35330207; PMCID: PMC8949289.
Clarke S. F., Murphy E. F., O'Sullivan O., et al. Exercise and associated dietary extremes impact on gut microbial diversity. Gut. 2014;63(12):1913–1920. doi: 10.1136/gutjnl-2013-306541.
Monda V, Villano I, Messina A, Valenzano A, Esposito T, Moscatelli F, Viggiano A, Cibelli G, Chieffi S, Monda M, Messina G. Exercise Modifies the Gut Microbiota with Positive Health Effects. Oxid Med Cell Longev. 2017;2017:3831972. doi: 10.1155/2017/3831972. Epub 2017 Mar 5. PMID: 28357027; PMCID: PMC5357536.
Bermon S., Petriz B., Kajeniene A., Prestes J., Castell L., Franco O. L. The microbiota: an exercise immunology perspective. Exercise Immunology Review. 2015;21:70–79.
Remely M., Aumueller E., Jahn D., Hippe B., Brath H., Haslberger A. G. Microbiota and epigenetic regulation of inflammatory mediators in type 2 diabetes and obesity. Beneficial Microbes. 2014;5(1):33–43. doi: 10.3920/BM2013.006.
Liu BN, Liu XT, Liang ZH, Wang JH. Gut microbiota in obesity. World J Gastroenterol. 2021 Jul 7;27(25):3837-3850. doi: 10.3748/wjg.v27.i25.3837. PMID: 34321848; PMCID: PMC8291023.
Karl JP, Margolis LM, Madslien EH, Murphy NE, Castellani JW, Gundersen Y, et al.. Changes in intestinal microbiota composition and metabolism coincide with increased intestinal permeability in young adults under prolonged physiological stress. Am J Physiol Gastrointest Liver Physiol. (2017) 312:G559–71. 10.1152/ajpgi.00066.2017
Jeukendrup AE, Vet-Joop K, Sturk A, Stegen JH, Senden J, Saris WH, et al.. Relationship between gastro-intestinal complaints and endotoxaemia, cytokine release and the acute-phase reaction during and after a long-distance triathlon in highly trained men. Clin Sci. (2000) 98:47–55. 10.1042/cs0980047
Quigley EM. Gut bacteria in health and disease. Gastroenterol Hepatol (N Y). 2013 Sep;9(9):560-9. PMID: 24729765; PMCID: PMC3983973
Collado MC, Rautava S, Aakko J, Isolauri E, Salminen S. Human gut colonisation may be initiated in utero by distinct microbial communities in the placenta and amniotic fluid. Sci Rep. 2016;6:23129.
Rackaityte, E. et al. Viable bacterial colonization is highly limited in the human intestine in utero. Nat. Med. 26, 599–607 (2020).
Milani C., Duranti S., Bottacini F., Casey E., Turroni F., Mahony J., Belzer C., Delgado Palacio S., Arboleya Montes S., Mancabelli L., et al. The First Microbial Colonizers of the Human Gut: Composition, Activities, and Health Implications of the Infant Gut Microbiota. Microbiol. Mol. Biol. Rev. 2017;81:e00036-17. doi: 10.1128/MMBR.00036-17.
Martin R, Makino H, Cetinyurek Yavuz A, et al. Early-Life Events, Including Mode of Delivery and Type of Feeding, Siblings and Gender, Shape the Developing Gut Microbiota. PLoS One. 2016;11(6):e0158498.
Indrio F, Martini S, Francavilla R, Corvaglia L, Cristofori F, Mastrolia SA, Neu J, Rautava S, Russo Spena G, Raimondi F, et al. Epigenetic matters: the link between early nutrition, microbiome, and long-term health development. Front Pediatr. 2017;5:178. doi: 10.3389/fped.2017.00178.
Yatsunenko T, Rey FE, Manary MJ, Trehan I, Dominguez-Bello MG, Contreras M, Magris M, Hidalgo G, Baldassano RN, Anokhin AP, et al. Human gut microbiome viewed across age and geography. Nature. 2012;486(7402):222–227. doi: 10.1038/nature11053.
Grech A, Collins CE, Holmes A, Lal R, Duncanson K, Taylor R, Gordon A. Maternal exposures and the infant gut microbiome: a systematic review with meta-analysis. Gut Microbes. 2021 Jan-Dec;13(1):1-30. doi: 10.1080/19490976.2021.1897210. PMID: 33978558; PMCID: PMC8276657.
Bergström A, Skov TH, Bahl MI, Roager HM, Christensen LB, Ejlerskov KT, Mølgaard C, Michaelsen KF, Licht TR. Establishment of intestinal microbiota during early life: a longitudinal, explorative study of a large cohort of Danish infants. Appl Environ Microbiol. 2014;80(9):2889–2900. doi: 10.1128/AEM.00342-14.
Arboleya S, Binetti A, Salazar N, Fernández N, Solís G, Hernández-Barranco A, Margolles A, de Los Reyes-Gavilán CG, Gueimonde M. Establishment and development of intestinal microbiota in preterm neonates. FEMS Microbiol Ecol. 2012;79(3):763–772. doi: 10.1111/j.1574-6941.2011.01261.x.
Bridgman S.L., Azad M.B., Field C.J., Haqq A.M., Becker A.B., Mandhane P.J., Subbarao P., Turvey S.E., Sears M.R., Scott J.A., et al. Fecal Short-Chain Fatty Acid Variations by Breastfeeding Status in Infants at 4 Months: Differences in Relative versus Absolute Concentrations. Front. Nutr. 2017;4:11. doi: 10.3389/fnut.2017.00011.
Heavey P.M., Savage S.A., Parrett A., Cecchini C., Edwards C.A., Rowland I.R. Protein-degradation products and bacterial enzyme activities in faeces of breast-fed and formula-fed infants. Br. J. Nutr. 2003;89:509–515. doi: 10.1079/BJN2002814.
Fujimura, K. E. et al. Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation. Nat. Med. 22, 1187–1191 (2016).
Hidalgo-Cantabrana C., Delgado S., Ruiz L., Ruas-Madiedo P., Sánchez B., Margolles A. Bifidobacteria and Their Health-Promoting Effects. Microbiol. Spectr. 2017;5:5. doi: 10.1128/microbiolspec.BAD-0010-2016.
Hazan S, Dave S, Papoutsis AJ, Deshpande N, Howell MC Jr, Martin LM. Vitamin C improves gut Bifidobacteria in humans. Future Microbiol. 2022 Dec 8. doi: 10.2217/fmb-2022-0209. Epub ahead of print. PMID: 36475828.
Walton G. E., Lu C., Trogh I., Arnaut F., Gibson G. R. (2012). A randomised, double-blind, placebo controlled cross-over study to determine the gastrointestinal effects of consumption of arabinoxylan-oligosaccharides enriched bread in healthy volunteers. Nutr. J. 11, 36. 10.1186/1475-2891-11-36
Veereman-Wauters G., Staelens S., Van De Broek H., Plaskie K., Wesling F., Roger L. C., et al.. (2011). Physiological and bifidogenic effects of prebiotic supplements in infant formulae. J. Pediatr. Gastroenterol. Nutr. 52, 763–771. 10.1097/MPG.0b013e3182139f39
Ferreira-Halder C.V., de Sousa Faria A.V., Andrade S.S. Action and function of Faecalibacterium prausnitzii in health and disease. Best Pract. Res. Clin. Gastroenterol. 2017;31:643–648. doi: 10.1016/j.bpg.2017.09.011.
Verhoog S, Taneri PE, Roa Díaz ZM, Marques-Vidal P, Troup JP, Bally L, Franco OH, Glisic M, Muka T. Dietary Factors and Modulation of Bacteria Strains of Akkermansia muciniphila and Faecalibacterium prausnitzii: A Systematic Review. Nutrients. 2019 Jul 11;11(7):1565. doi: 10.3390/nu11071565. PMID: 31336737; PMCID: PMC6683038.
Shen Z., Zhu C., Quan Y., Yang J., Yuan W., Yang Z., Wu S., Luo W., Tan B., Wang X. Insights into Roseburia intestinalis which alleviates experimental colitis pathology by inducing anti-inflammatory responses. J. Gastroenterol. Hepatol. 2018;33:1751–1760. doi: 10.1111/jgh.14144.
Bindels L. B., Neyrinck A. M., Salazar N., Taminiau B., Druart C., Muccioli G. G., et al.. (2015). Non Digestible Oligosaccharides Modulate the Gut Microbiota to Control the Development of Leukemia and Associated Cachexia in Mice. PloS One 10 (6), e0131009. doi: 10.1371/journal.pone.0131009
Lee C.J., Sears C.L., Maruthur N. Gut microbiome and its role in obesity and insulin resistance. Ann. N. Y. Acad. Sci. 2019;1461:37–52. doi: 10.1111/nyas.14107.
Alemán JO, Bokulich NA, Swann JR, Walker JM, De Rosa JC, Battaglia T, et al. Fecal microbiota and bile acid interactions with systemic and adipose tissue metabolism in diet-induced weight loss of obese postmenopausal women. J Transl Med. 2018;16:244.
Slattery C., Cotter P.D., O’Toole P.W. Analysis of Health Benefits Conferred by Lactobacillus Species from Kefir. Nutrients. 2019;11:1252. doi: 10.3390/nu11061252.
Lü M, Yu S, Deng J, Yan Q, Yang C, Xia G, Zhou X. Efficacy of Probiotic Supplementation Therapy for Helicobacter pylori Eradication: A Meta-Analysis of Randomized Controlled Trials. PLoS One. 2016 Oct 10;11(10):e0163743. doi: 10.1371/journal.pone.0163743. PMID: 27723762; PMCID: PMC5056761.
Aslam H, Marx W, Rocks T, Loughman A, Chandrasekaran V, Ruusunen A, Dawson SL, West M, Mullarkey E, Pasco JA, Jacka FN. The effects of dairy and dairy derivatives on the gut microbiota: a systematic literature review. Gut Microbes. 2020 Nov 9;12(1):1799533. doi: 10.1080/19490976.2020.1799533. PMID: 32835617; PMCID: PMC7524346.
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