Therapeutic effects of creatine supplementation in patients with type II diabetes
DOI:
https://doi.org/10.12775/JEHS.2023.16.01.008Keywords
type 2 diabetes, creatine supplementationAbstract
Background: Type 2 diabetes mellitus (T2DM) prevalence is disturbingly increasing all over the world. Clinicians and patients need new ways of improving T2DM therapy.
Aim of this study: The aim of this study is to present the current scientific literature on the potential hypoglycemic effects of creatine in patients with type 2 diabetes.
Material and methods: A systematic review of the scientific and medical literature from the PubMed and Google Scholar databases was carried out. This was achieved according to the keywords: type 2 diabetes and creatine supplementation. 25 items of literature were qualified for analysis.
Results and conclusions:
Creatine supplementation, when combined with physical activity, improves glycemic control in type 2 diabetic patients. Increased glucose transfer into muscle cells by type 4 glucose transporter (GLUT-4) translocation to the sarcolemma is one of the potential mechanisms explaining these hypoglycemic effects. Creatine has a big potential to become a nutritional therapy adjuvant for type 2 diabetes. However, in order to draw firm conclusions about the efficacy and safety of creatine as a diabetic intervention, larger, longer-term, controlled trials involving type 2 diabetes with variable disease severity and different pharmacological treatments are required.
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Copyright (c) 2023 Aleksander Oskroba, Mateusz Pawlina, Aleksandra Orzechowska, Karolina Ziętara, Natalia Pawełczak, Karolina Raksa, Bartłomiej Zielonka, Ilona Kowalczyk, Piotr Pawłowski, Cezary Stawikowski
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