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Journal of Education, Health and Sport

B vitamins in diseases of the nervous system - facts and myths
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B vitamins in diseases of the nervous system - facts and myths

Authors

  • Damian Jasłowski Wojewódzki Szpital Specjalistyczny im. Stefana Kardynała Wyszyńskiego Samodzielny Publiczny Zakład Opieki Zdrowotnej w Lublinie https://orcid.org/0000-0003-1943-7213

DOI:

https://doi.org/10.12775/JEHS.2023.13.05.014

Keywords

homocysteine, niacin, riboflavin, thiamin, neuropathy, pain

Abstract

Introduction: B vitamins are necessary for the proper functioning of the nervous system, taking part in the synthesis of neurotransmitters, RNA and DNA and acting as cofactors in many cellular metabolic pathways. The body does not store them, so they need to be replaced daily. Mild deficiencies can cause non-specific neuropsychiatric disorders, and deep and persistent - serious, fatal disease states that require intensive supplementation, such as beriberi disease or Korsakoff's syndrome.

Materials and methods: My work is based on the articles published in PubMed, medical books and websites. I was looking for the key words such as ‘biotin‘, ‘brain’, ‘homocysteine’, ‘niacin’, ‘pantothenic acid’, ‘riboflavin’, ‘thiamin’, ‘neuropathy’.

Results: B vitamins seem to enhance the analgesic effect of NSAIDs. There is evidence of supportive action in the treatment of low back pain and diabetic neuropathy. There is no reliable evidence of improved cognitive function in patients with Alzheimer's disease or other types of dementia.

Conclusions: due to the low toxicity, very few side effects and experimental findings, it seems reasonable to administer B vitamins in numerous pain syndromes, such as neuropathies and back pain syndromes. However, we need more randomized clinical trials to create universal recommendations and finally confirm the positive effects of these substances in neurological diseases.

References

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Irena Bubko, Beata M. Gruber, Elżbieta L. Anuszewska Rola tiaminy w chorobach neurodegeneracyjnych Postepy Hig Med Dosw 2015; 69 : 1096-1106

Tylicki A, Siemieniuk M. Tiamina i jej pochodne w regulacji metabolizmu komórek [Thiamine and its derivatives in the regulation of cell metabolism. Postepy Hig Med Dosw (Online). 2011 Jul 6;65:447-69. Polish. doi: 10.5604/17322693.951633. PMID: 21734329

Wiley KD, Gupta M. Vitamin B1 Thiamine Deficiency. [Updated 2022 Jul 22]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-.

Covell T, Siddiqui W. Korsakoff Syndrome. [Updated 2022 Jul 20]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available

Vitamin B6 Fact Sheet for Health Professionals, https://ods.od.nih.gov/factsheets/VitaminB6-HealthProfessional/#en20]

Hughes CF, Ward M, Hoey L, McNulty H. Vitamin B12 and ageing: current issues and interaction with folate. Annals of Clinical Biochemistry. 2013;50(4):315-329. doi:10.1177/0004563212473279

https://www.mp.pl/pacjent/leki/subst.html?id=188

Buesing S, Costa M, Schilling JM, Moeller-Bertram T. Vitamin B12 as a Treatment for Pain. Pain Physician. 2019 Jan;22(1):E45-E52. PMID: 30700078.

Jurna I, Reeh PW. Sind B-Vitamine sinnvolle Zusätze zu Analgetika? : Bericht über ein Symposium bei der 16. Jahrestagung der Deutschen Gesellschaft zum Studium des Schmerzes e.V., Berlin, 24.-27. Oktober 1991 [How useful is the combination of B vitamins and analgesic agents?]. Schmerz. 1992 Sep;6(3):224-6. German. doi: 10.1007/BF02528609. PMID: 18415613.

Jurna I. Analgetische und analgesiepotenzierende Wirkung von B-Vitaminen [Analgesic and analgesia-potentiating action of B vitamins]. Schmerz. 1998 Apr 20;12(2):136-41. German. doi: 10.1007/s004829800054. PMID: 12799982.

Mauro GL, Martorana U, Cataldo P, Brancato G, Letizia G. Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study. Eur Rev Med Pharmacol Sci. 2000 May-Jun;4(3):53-8. PMID: 11558625.

Rafał Furgała, Monika Stompor-Gorący, Effects of vitamin B12 supplementation on pain relief in certain diseases – a literature review, The Journal of the Polish Biochemical Society and of the Committee of Biochemistry and Biophysics Polish Academy of Sciences, Vol. 69 No. 2 (2022), p. 265-271

Selhub J. Public health significance of elevated homocysteine. Food Nutr Bull. 2008 Jun;29(2 Suppl):S116-25. doi: 10.1177/15648265080292S116. PMID: 18709886.

Zhang DM, Ye JX, Mu JS, Cui XP. Efficacy of Vitamin B Supplementation on Cognition in Elderly Patients With Cognitive-Related Diseases. J Geriatr Psychiatry Neurol. 2017 Jan;30(1):50-59. doi: 10.1177/0891988716673466. Epub 2016 Oct 17. PMID: 28248558.

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Published

2023-03-11

How to Cite

1.
JASŁOWSKI, Damian. B vitamins in diseases of the nervous system - facts and myths. Journal of Education, Health and Sport. Online. 11 March 2023. Vol. 13, no. 5, pp. 100-104. [Accessed 1 July 2025]. DOI 10.12775/JEHS.2023.13.05.014.
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Vol. 13 No. 5 (2023)

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Copyright (c) 2023 Damian Jasłowski

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