Nigella Sativa - an ordinary herb or a miraculous medicine?
DOI:
https://doi.org/10.12775/JEHS.2023.13.05.001Keywords
Black Cumin, Nigella Sativa, Thymoquinone, herbal preparationsAbstract
Nowadays, herbal preparations are increasingly used in medicine. These preparations are cheaper, more available and they have fewer side effects than synthetic ones. Nigella Sativa, commonly known as Black Cumin, has been used in traditional medicine since antiquity. This herb is known to have many properties. The prophet Muhammad himself has already mentioned them, claiming that “Black Cumin is a cure for all diseases except death". Researches on N. Sativa confirmed that it has anti-diabetic, anti-asthmatic, pro-fertility, antioxidant, hepatoprotective, neuroprotective, gastroprotective, immunomodulatory, analgesic, antibacterial, anti-inflammatory and anti-ischemic effects. Many of these properties are due to thymoquinone, which is the main component of black cumin essential oil. This present review is an attempt to provide a specific overview of researches and literatures of pharmacognostical profile and pharmacological activity of the seeds of this plant. It will be helpful for scientists, researchers and other healthcare professionals, who are working with this plant and who need to be up to date about it.
References
Ahmad A, Husain A, Mujeeb M, Khan SA, Najmi AK, Siddique NA, Damanhouri ZA, Anwar F. A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pac J Trop Biomed. 2013 May;3(5):337-52. doi: 10.1016/S2221-1691(13)60075-1. PMID: 23646296; PMCID: PMC3642442.
Randhawa, M. A., & Al-Ghamdi, M. S. (2002). A review of the pharmaco- therapeutic effects of Nigella sativa. Pakistan Journal of Medical Research, 41(2), 77–83.
Salem, M. L. (2005). Immunomodulatory and immunotherapeutic prop- erties of the Nigella sativa L. seed. International Immunopharmacology, 5(13-14), 1749–1770. https://doi.org/10.1016/j.intimp.2005.06.008
Khaled, A. A. S. (2009). Gastroprotective effects of Nigella Sativa oil on the formation of stress gastritis in hypothyroidal rats. International Journal of Physiology, Pathophysiology and Pharmacology, 1, 143–149.
Atasever, M., Bakacak, Z., 2017. Nigella sativa oil protects the rat ovary from oxidative injury due to ischemia-reperfusion. Med. Sci. Monit. 23, 5027–5033.
Mohebbati, R., Shafei, M.N., Beheshti, F., Soukhtanloo, M., Roshan, N.M., Anaeigoudari, A., Parhizgar, S., Hosseinian, S., Khazdeir, M.R., Rad, A.K., 2017. Mixed hydroalcoholic extracts of Nigella sativa and Curcuma longa improves adriamycin-induced renal injury in rat. Saudi J. Kidney Dis. Transpl. 28 (6), 1270–1281.
Pakdel, R., Hadjzadeh, H., Sadegh, M.M., Hosseini, M., Emami, B., Hadjzadeh, M., 2017. The effects of hydroalcoholic extract of Nigella sativa seeds on serum estradiol and prolactin levels and obstetric criteria due to hypothyroidism in rat. Adv. Biomed. Res. 6, 166.
Khader M, Eckl PM. Thymoquinone: an emerging natural drug with a wide range of medical applications. Iran J Basic Med Sci. 2014;17:950–7.
Panahi M, Namjoyan F, Shakerin Z. Evaluation of antioxidant effects of Nigella sativa on the ultrastructure of neural tube defects in diabetic rats offspring. Jundishapur J Nat Pharm Prod. 2011;6(1):16–23.
Goga A, Hasic S, Becirovic S, Cavar S. Phenolic compounds and antioxidant Activity of extracts of Nigella sativa L. Bull Chemists Technol Bosnia Herzegovina. 2012;39:15–9.
Houcher Z, Boudiaf K, Benboubetra M, Houcher B. Effects of methanolic extract and commercial oil of Nigella sativa L. on blood glucose and antioxidant capacity in alloxan-induced diabetic rats. Pteridines. 2007;18(1):8–18.
Hmza AJA, Osman MT, Adnan A, Omar A. Immunomodulatory effect of Nigella Sativa oil in the disease process of type 1 diabetic rats. Res J Pharm, Bio Chem Sci. 2013;4(1):980–8.
Noor NA, Fahmy HM, Mohammed FF, Elsayed AA, Radwan NM. Nigella sativa ameliorates inflammation and demyelination in the experimental autoimmune encephalomyelitis-induced Wistar rats. Int J Clin Exp Pathol. 2015;8(6):6269–86.
Medenica R, Janssens J, Tarasenko A, Lazovic G, Corbitt W, Powell D, et al. Anti-angiogenic activity of Nigella sativa plant extract in cancer therapy. Proc Annual Meeting Am Assoc Cancer Res. 1997;38:A1377.
Iddamaldeniya SS, Thabrew MI, Wickramasinghe SMDN, Ratnatunge N, Thammitiyagodage MG. A long-term investigation of the anti-hepatocarcinogenic potential of an indigenous medicine comprised of Nigella sativa, Hemidesmus indicus and Smilax glabra. J Carcinog. 2006;5(1):11–7.
Farhangi MA, Dehghan P, Tajmiri S, Abbasi MM. The effects of Nigella sativa on thyroid function, serum Vascular Endothelial Growth Factor (VEGF) - 1, Nesfatin-1 and anthropometric features in patients with Hashimoto's thyroiditis: a randomized controlled trial. BMC Complement Altern Med. 2016 Nov 16;16(1):471. doi: 10.1186/s12906-016-1432-2. PMID: 27852303; PMCID: PMC5112739.
Al-Bukhari MI. In: The collection of authentic sayings of prophet Mohammad (peace be upon him), division 71 on medicine. 2nd ed. Al-Bukhari, Sahih, editors. Ankara, Turkey: Hilal Yayinlari; 1976.
Kaatabi H, Bamosa AO, Badar A, Al-Elq A, Abou-Hozaifa B, Lebda F, et al. Nigella sativa improves glycemic control and ameliorates oxidative stress in patients with type 2 diabetes mellitus: placebo controlled participant blinded clinical trial. PloS one. 2015;10(2) doi: 10.1371/journal.pone.0113486.
Bamosa AO, Kaatabi H., Lebdaa FM, Elq AM, Al-Sultanb A. Wpływ nasion Nigella sativa na kontrolę glikemii pacjentów z cukrzycą typu 2. Indian J. Physiol. Pharmacol. 2010; 54 :344-354.
Ahmad B., Tariq M., Uppal AM, Naveed AK Wpływ oleju z Nigella sativa na niektóre parametry krwi u pacjentów z cukrzycą typu 2. Azjatycki J. Chem. 2009; 21 :5373–5381
El-Shamy KA, Mosa MMA, El-Nabarawy SK, El-Qattan M. Wpływ herbaty Nigella sativa u pacjentów z cukrzycą typu 2 na homeostazę glukozy, funkcje wątroby i nerek. J. Appl. Nauka. Res. 2011; 7 : 1982-1991
Hosseini MS, Mirkarimi SA, Amini M., Mohtashami R., Kianbakht S., Fallah Huseini H. Wpływ oleju z nasion Nigella sativa L. u pacjentów z cukrzycą typu II: randomizowane, podwójnie zaślepione, kontrolowane placebo badanie kliniczne. JMPIR. 2013; 3 :93–99
Kheirouri S, Hadi V, Alizadeh M. Immunomodulatory effect of Nigella sativa oil on T lymphocytes in patients with rheumatoid arthritis. Immunol Invest. 2016;45(4):271–83. doi: 10.3109/08820139.2016.1153649
Gheita TA, Kenawy SA. Effectiveness of Nigella sativa oil in the management of rheumatoid arthritis patients: a placebo controlled study. Phytother Res. 2012;26(8):1246–8. doi: 10.1002/ptr.3679
Hadi V, Kheirouri S, Alizadeh M, Khabbazi A, Hosseini H. Effects of Nigella sativa oil extract on inflammatory cytokine response and oxidative stress status in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled clinical trial. Avicenna J Phytomed. 2016;6(1):34–43
Lebda FM, Bamosa AO, Kaatabi H, Al Elq A, Al-Sultan A. Effect of Nigella sativa on hemodynamics, hemoglobin, and blood coagulation in patients with type 2 diabetes. The Egyptian Journal of Haematology. 2012;37(2):73
Boskabady MH, Mohsenpoor N, Takaloo L. Antiasthmatic effect of Nigella sativa in airways of asthmatic patients. Phytomedicine. 2010;17(10):707–13. doi: 10.1016/j.phymed.2010.01.002
Salem AM, Bamosa AO, Qutub HO, Gupta RK, Badar A, Elnour A, et al. Effect of Nigella sativa supplementation on lung function and inflammatory mediators in partly controlled asthma: a randomized controlled trial. Ann Saudi Med. 2017;37(1):64–71. doi: 10.5144/0256-4947.2017.64
Avci G, Ulutas E, Ozdemir V, Kivrak I, Bulbul A. The positive effect of black seed (Nigella sativa L.) essential oil on thyroid hormones in rats with hypothyroidism and hyperthyroidism. J Food Biochem. 2022 Apr;46(4):e13801. doi: 10.1111/jfbc.13801. Epub 2021 Jun 3. PMID: 34080722.
Nemmar A, Al-Salam S, Zia S, Marzouqi F, Al-Dhaheri A, Subramaniyan D, et al. Contrasting actions of diesel exhaust particles on the pulmonary and cardiovascular systems and the effects of thymoquinone. Br J Pharmacol 2011; 164(7): 1871-1882.
El-Dakhakhny, M., Barakat, M., El-Halim, M.A., Aly, S., 2000. Effects of Nigella sativa oil on gastric secretion and ethanol induced ulcer in rats. J. Ethnopharmacol. 72 (1), 299–304.
Rifat-uz-Zaman, M.S.A., Khan, M.S., 2004. Gastroprotective and anti-secretory effect of Nigella sativa seed and its extracts in indomethacin-treated rats. Pak. J. Biol. Sci. 7, 995–1000.
Kanter, M., Coskun, O., Uysal, H., 2006. The antioxidative and antihistaminic effect of Nigella sativa and its major constituent, thymoquinone on ethanol-induced gastric mucosal damage. Arch. Toxicol. 80 (4), 217–224.
Magdy, M.-A., Hanan, E.-A., Nabila, E.-M., 2012. Thymoquinone: Novel gastroprotective mechanisms. Eur. J. Pharmacol. 697 (1), 126–131.
Gholamnezhad Z, Shakeri F, Saadat S, Ghorani V, Boskabady MH. Clinical and experimental effects of Nigella sativa and its constituents on respiratory and allergic disorders. Avicenna J Phytomed. 2019 May-Jun;9(3):195-212. PMID: 31143688; PMCID: PMC6526035.
Ansari MA, Ahmed SP, Haider S, Ansari N. 2006. Nigella sativa: A non-conventional herbal option for the management of seasonal allergic rhinitis. Pak J Pharmacol, 23:31-35.
Ansari MA, Ansari NA, Junejo SA. 2010. Montelukast versus nigella sativa for management of seasonal allergic rhinitis: A single blind comparative clinical trial. Pak J Med Sci, 26:249-254.
Rizka A, Setiati S, Lydia A, Dewiasty E. Effect of Nigella sativa Seed Extract for Hypertension in Elderly: a Double-blind, Randomized Controlled Trial. Acta Med Indones. 2017 Oct;49(4):307-313. PMID: 29348380.
Parandin R., Yousofvand N., Ghorbani R. The enhancing effects of alcoholic extract of Nigella sativa seed on fertility potential, plasma gonadotropins and testosterone in male rats. Iranian Journal of Reproductive Medicine. 2012;10(4):355–362
Kolahdooz M., Nasri S., Modarres S. Z., Kianbakht S., Huseini H. F. Effects of Nigella sativa L. seed oil on abnormal semen quality in infertile men: A randomized, double-blind, placebo-controlled clinical trial. Phytomedicine. 2014;21(6):901–905. doi: 10.1016/j.phymed.2014.02.006
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