The impact of educating blood donors on plasmapheresis and plasma applications on the availability of plasma-derived medicinal products
DOI:
https://doi.org/10.12775/JEHS.2023.13.04.023Keywords
plasmapheresis, plasma-derived medicinal products, donorsAbstract
Introduction: Human plasma contains valuable proteins such as albumin, globulins and coagulation factors. These ingredients are used to obtain medicinal products (PDMPs - plasma-derived medicinal products) used in many fields of medicine. The growing number of indications for their use causes an increase in the demand for plasma collected from blood donors. Most donors, however, choose to donate whole blood, which provides a lower amount of plasma than plasmapheresis.
Purpose of the study: This study aims to indicate the reasons why donors do not decide to donate plasma by apheresis, to show the role of informing donors about the plasmapheresis, about the uses of plasma collected and about the safety of the process. The work also presents examples of PDMPs applications that can be used in the process of educating donors, which may contribute to increasing the number of plasma donors and, at the same time, the availability of PDMPs.
Material and methods: A review of scientific research (using Pubmed, Google Scholar databases), medical books and materials published on websites of institutions related to blood donation regulations was conducted.
Results: The reasons why blood donors do not decide to donate plasma include, among others, longer donation time and lack of knowledge about plasmapheresis. The decision to donate plasma via plasmapheresis is influenced not only by the fact of informing the donor about such a possibility, but also by the content and manner of providing the information. Due to the greater amount of plasma obtained each time by plasmapheresis compared to the separation of whole blood, an increase in the number of donors undergoing plasmapheresis may indirectly positively affect the availability of plasma-derived medicinal products
References
Sawicki W., Malejczyk J.: Krew in “Histologia”, PZWL, Warszawa 2014, p.219-220, Polish
Cheraghali AM, Abolghasemi H. Improving availability and affordability of plasma-derived medicines. Biologicals. 2010 Jan;38(1):81-6. doi: 10.1016/j.biologicals.2009.10.004. PMID: 20137973.
Hotchko M, Robert P. Recent market status and trends of fractionated plasma products. Ann Blood 2018;3:19 doi: 10.21037/aob.2018.01.06
WHO RECOMMENDATIONS FOR THE PRODUCTION, CONTROL AND REGULATION OF HUMAN PLASMA FOR FRACTIONATION Adopted by the 56 th meeting of the WHO Expert Committee on Biological Standardization, 24-28 October 2005. https://cdn.who.int/media/docs/default-source/biologicals/blood-products/ecbs-2005-annex-4-human-plasma-fractionation.pdf?sfvrsn=50177626_2&download=true
WHO is not responsible for the content or accuracy of this translation. The original English edition shall be the binding and authentic edition.
21 U.S. Code of Federal Regulations (CFR). Title 21. Part 640. Additional standards for human blood and blood products e-CFR data, CFR 640.65 up to date as of 1/13/2023, https://www.ecfr.gov/current/title-21/chapter-I/subchapter-F/part-640#640.65 (accessed on 18.01.2023r.)
Guide to the preparation, use and quality assurance of blood components, Recommendation No. R (95) 15, 20th edition, EUROPEAN COMMITTEE (PARTIAL AGREEMENT) ON BLOOD TRANSFUSION (CD‑P‑TS) European Directorate for the Quality of Medicines (EDQM). Council of Europe https://www.edqm.eu/en/blood-guide
Global status report on blood safety and availability 2021. Geneva: World Health Organization; 2022. Licence: CC BY-NCSA 3.0 IGO. This translation was not created by the World Health Organization (WHO). WHO is not responsible for the content or accuracy of this translation. The original English edition shall be the binding and authentic edition
Guidance on increasing supplies of plasma-derived medicinal products in low- and middle-income countries through fractionation of domestic plasma. Geneva: World Health Organization; 2021. Licence: CC BY-NC-SA 3.0 IGO. : This translation was not created by the World Health Organization (WHO). WHO is not responsible for the content or accuracy of this translation. The original English edition shall be the binding and authentic edition.
Charakterystyka Produktu Leczniczego Human Albumin CSL Behring 200 g/l, 200 g/l, roztwór do infuzji, https://labeling.csl.com/SMPC/PL/HumanAlbumin/PL/HumanAlbumin-spc.pdf accessed on 18.01.2023, Polish
Gupta A, Patibandla S. Protein C Deficiency. [Updated 2022 Jul 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK542222/
The role of alpha-1-antitrypsin protein in the pathogenesis of abdominal aortic aneurysm
Agata Wanda Dżeljilji, Joanna Chorostowska-Wynimko, Dariusz Szewczyk, Wojciech Popiołek, Artur Kierach, Piotr Andziak
DOI: 10.5603/AA.2018.0006 Acta Angiologica 2018;24(1):30-33
Berger, Mel MD, PhD1; Lefaucheur, Carmen MD2,3; Jordan, Stanley C. MD4. Update on C1 Esterase Inhibitor in Human Solid Organ Transplantation. Transplantation 103(9):p 1763-1775, September 2019. | DOI: 10.1097/TP.0000000000002717
Goczyńska P, Lasocka J, Lachert E. Fibrin glues — the current state of knowledge. J Trans Med 2021; 14 (4): 214–224. DOI: 10.5603/JTM.2021.0012
Lo MS, Newburger JW. Role of intravenous immunoglobulin in the treatment of Kawasaki disease. Int J Rheum Dis. 2018 Jan;21(1):64-69. doi: 10.1111/1756-185X.13220. Epub 2017 Dec 5. PMID: 29205910.
Mulhearn B, Bruce IN. Indications for IVIG in rheumatic diseases. Rheumatology (Oxford). 2015 Mar;54(3):383-91. doi: 10.1093/rheumatology/keu429. Epub 2014 Nov 17. PMID: 25406359; PMCID: PMC4334686.
Huang YR, Xie XX, Ji M, Yu XL, Zhu J, Zhang LX, Liu XG, Wei C, Li G, Liu RT. Naturally occurring autoantibodies against α-synuclein rescues memory and motor deficits and attenuates α-synuclein pathology in mouse model of Parkinson's disease. Neurobiol Dis. 2019 Apr;124:202-217. doi: 10.1016/j.nbd.2018.11.024. Epub 2018 Nov 24. PMID: 30481547.
Beurel A, Terrade F, Lebaudy JP, Danic B. Determinants of plasma donation: A review of the literature. Transfus Clin Biol. 2017 Sep;24(3):106-109. doi: 10.1016/j.tracli.2017.06.001. Epub 2017 Jun 20. PMID: 28645645.
Bove, L.L., Bednall, T., Masser, B. and Buzza, M. (2011), Understanding the plasmapheresis donor in a voluntary, nonremunerated environment. Transfusion, 51: 2411-2424. https://doi.org/10.1111/j.1537-2995.2011.03168.x
Gaston Godin, Marc Germain, "How to Motivate Whole Blood Donors to Become Plasma Donors", Journal of Blood Transfusion, vol. 2014, Article ID 752182, 6 pages, 2014. https://doi.org/10.1155/2014/752182
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Jakub Sutkowski, Ewelina Wilczewska, Kamila Matyka, Anna Słowiaczek, Alicja Baranowska, Marcin Wojnar, Aleksandra Matyszewska
![Creative Commons License](http://i.creativecommons.org/l/by-nc-sa/4.0/88x31.png)
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 308
Number of citations: 0