Antioxidant system of oral cavity in children with inflammatory diseases oral mucosa and acute forms of leukemia under the treatment

Abstract

Kovach I. V., Khotimskаy J. V. Antioxidant system of oral cavity in children with inflammatory diseases oral mucosa and acute forms of leukemia under the treatment. Journal of Education, Health and Sport. 2017;7(1):387-395. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.276515

http://ojs.ukw.edu.pl/index.php/johs/article/view/4246

The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 754 (09.12.2016).

754 Journal of Education, Health and Sport eISSN 2391-8306 7

© The Author (s) 2017;

This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland

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This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.

The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 02.01.2017. Revised 16.01.2017. Accepted: 24.01.2017.

ANTIOXIDANT SYSTEM OF ORAL CAVITY IN CHILDREN WITH INFLAMMATORY DISEASES ORAL MUCOSA AND ACUTE FORMS

OF LEUKEMIA UNDER THE TREATMENT

I. V. Kovach, J. V. Khotimskаy

State Enterprise «Dnepropetrovsk Medical Academy under

Ukrainian Ministry of Health»

khotimskaya@ukr.net

Summary

The children with inflammatory diseases of the oral mucosa on the background of acute leukemia develop antioxidant system pronounced changes, e.g. the level of its enzymatic and non-enzymatic components reduces. This increases oxidative homeostasis disorders and decreases catalase’s activity. We have developed  treatment-and-prophylactic complex containing quercetin mucosal gel and gel with a large number of polyphenols, flavonols, anthocyanins and catechins ("Vinaceous"), and dentilave "Lysomucoid", mixture of sanguinarine alkaloids disulfate and chelerythrine, anti-fungal and probiotic preparations. This complex has a pronounced stimulatory effect on the state of the antioxidant system, which largely determines the general condition of organs and tissues of the oral cavity. At the same time the developed therapeutic and preventive complex provides a consistently high level of functional activity of the antioxidant system in children with inflammatory diseases of the oral mucosa on the background of acute forms of leukemia in a year after treatment. The objective: to determine the activity of catalase in children with inflammatory diseases of the oral mucosa on the background of the acute form of leukemia in the dynamics of treatment. Materials and methods. 126 children aged 2-18 y.o. with acute lymphoblastic leukemia have been examined. All the children underwent clinical trials and then basic group and group of comparison was formed. In both groups the plaques were removed, full mouth debridement was made and systematically healthful procedures were done. Oral cavity hygiene was performed with the use of alcohol-free anti-inflammatory dentilave "Lysomucoid". The main group children additionally to oral hygiene used the developed therapeutic and prophylactic complexes. Results and Conclusions. The application of the developed therapeutic and prophylactic complexes, professional oral cavity hygiene and subsequent treatment applications had a pronounced  stimulating effect at the state of the antioxidant system, which depends greatly on the state of periodontal tissues and oral mucosa. The therapeutical method worked out provides high level of functional activity of the antioxidant system in all groups. This is especially important for acute leukemia children.

Key words: leukemia, children, oral mucosa, antioxidant system, catalase.