The current state of the problem of drug hepatotoxicity and measures of its prevention and treatment
DOI:
https://doi.org/10.12775/JEHS.2023.30.01.010Keywords
drug hepatotoxicity, measures of its prevention and treatment, new approachesAbstract
Drug use is one of the most important causes of liver damage and ranks 3rd after viral diseases and alcohol.
Hepatotoxicity of drugs remains one of the urgent problems of modern medicine, as it leads to a decrease in the effectiveness of pharmacotherapy, development of serious complications that can cause disability and death. Such a side effect increases the length of stay of patients in the hospital and increases the cost of treatment. That is, the problem of hepatotoxicity is not only a medical, but also a social problem.
Research sources focused on modern views about drug hepatotoxicity are reviewed and summarized and new approaches to its prevention and treatment are analyzed.
Conclusions. Hepatotoxicity of drugs remains one of the urgent problems of modern medicine, as it leads to a decrease in the effectiveness of pharmacotherapy, development of serious complications that can cause disability and death. Such a side effect increases the length of stay of patients in the hospital and increases the cost of treatment. That is, the problem of hepatotoxicity is not only a medical, but also a social problem.
References
Kushnir I.E. (2020) Drug-induced liver injury: epidemiology, clinical manifestations, diagnostic criteria and principles of treatment. Health of Ukraine. Special issue "Gastroenterology. Hepatology. Coloproctology", 55(1):10-12.
Tkach S.M. (2018). Epidemiology, pathogenesis, diagnosis and treatment of drug-induced liver damage. Health of Ukraine, 53(2):31-33.
EASL Clinical Practice Guidelines: Drug-induced liver injury (2019). Journal of Hepatology:1-40.
Nedashkivskyi S.M. (2019). Drug-induced liver damage: principles of diagnosis, pathological changes and approaches to treatment. Emergency medicine, 97(2):63-70.
MacLaren. (2010) Hepatic and cholestatic disease. Drug-induced disease. Prevention. Detection and management. American Society of Health System, Pharmacist, Bethesta, сhapter 40:771–800.
Chalasani N., Björnsson E. (2010) Risk Factors for Idiosyncratic Drug-Induced Liver Injury // Gastroenterology, 138(7):2246-2259.
Chalasani N., Fontana R.J., Bonkovsky H.L. et al. (2008) Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States // Gastroenterology, 135:1924-1934.
Kharchenko N.V., Anokhina G.A., Kharchenko V.V. (2013) Complex multifunctional hepatoprotectors in the treatment of patients with non-alcoholic liver disease in comorbidity with hypertension. Medical Practitioner, 1:64–66.
Aithal G.P., Watkins P.B., Andrade R.J. et al. (2011) Case definition and phenotype standardization in drug–induced liver injury. Clin. Pharmacol. Ther., 89(6):806–815.
Bell L.N., Chalasani N. (2009) Epidemiology of idiosyncratic drug-induced liver injury. Semin. Liver Dis., 29 (4):337–347.
Leitner J. M., Graninger W., Thalhammer F. (2010) Hepatotoxicity of antibacterials: Pathomechanisms and Clinical. Infection., 38(1):3–11.
Mengoli M., Parmeggiani D., Mengoli M.C. et al. (2011) Drug-induced hepatotoxicity: clinical and biochemical features of 26 patients and a review of the literature. Recenti Prog. Med., 102(6):253–260.
Robles M., Toscano E., Cotta J. et al. (2010) Antibiotic-induced liver toxicity: mechanisms, clinical features and causality assessment. Curr Drug Saf., 5 (3):212–222.
Ye Н., Nelson L., Gоmez del Moral M. et al. (2018) Dissecting the molecular pathophysiology of drug-induced liver injury // World J Gastroenterol., 13(24):1373-1385.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Volodymyr Shmanko, Oleh Shmanko, Tetyana Lazarchuk
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 253
Number of citations: 0
