The role of the retinoids in topical treatment of skin diseases - the review of the literature
DOI:
https://doi.org/10.12775/JEHS.2023.13.03.040Keywords
retinoids, acne vulgaris, psoriasis, photoaging, tretinoin, vitamin aAbstract
INTRODUCTION:
Retinoids are a broad group of natural and synthetic compounds derived from vitamin A. Many studies have shown strong anti-aging effects, and they have also been shown to have therapeutic effects on acne vulgaris or psoriasis.
Vitamin A and its derivatives make the skin more elastic and smooth, cause a decrease in fine wrinkles and cause an increase in fibroblast activity and collagen fiber production.
Retinoid compounds regulate biological processes of the skin such as immune processes, angiogenesis, proliferation and differentiation.
THE AIM OF STUDY:
The purpose of this paper is to discuss the effects of retinoids and the use of the substances in skin diseases.
MATERIALS AND METHOD:
Literature review of PubMed, Google Scholar and Science Direct and evaluation of available randomized controlled trials using retinoids in terms of treatment effectiveness in terms of skin quality, anti-aging benefits use in dermatology.
CONCLUSIONS:
Vitamin A and its derivatives plays an important role in anty-aging prevention and treatment of skin diseases, such as acne vulgaris, psoriasis and photo-aging. There are still many ongoing studies and not known opportunities of its use to treat other skin diseases that we should be aware of and keep track of new papers that indicate such.
References
Ryszard Żaba, Bezpieczeństwo stosowania retinoidów Przewodnik Lekarza/Guide for GPS 7/2006 vol. 9
Siddharth Mukherjee, Abhijit Date, Vandana Patravale, Hans Christian Korting, Alexander Roeder, Günther Weindl; Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety;Clinical interventions in aging. 2006 Dec; 1(4): 327–348.
Valerie D. Callender, Hilary Baldwin, Fran E. Cook-Bolden, Andrew F. Alexis, Linda Stein Gold & Eric Guenin Effects of Topical Retinoids on Acne and Post-inflammatory Hyperpigmentation in Patients with Skin of Color: A Clinical Review and Implications for Practice, American Journal of Clinical Dermatology volume 23, 69–81 (2022)
Brandon Ramchatesingh, Amelia Martínez Villarreal, Domenico Arcuri, François Lagacé, Samy Abu Setah, Fadi Touma, Faris Al-Badarin, Ivan V. Litvinov; The Use of Retinoids for the Prevention and Treatment of Skin Cancers: An Updated Review; International Journal of Molecular Science 2022 Oct; 23(20): 12622.
Henryk Marona, Agnieszka Gunia, Elżbieta Pękala; Retinoidy – rola w farmakoterapii w aspekcie komórkowego mechanizmu działania; Farm Pol, 2010, 66(3): 187-192
Aleksandra Czarnota; Retinoidy. Mechanizm działania, właściwości oraz zakres stosowania w dermatologii i kosmetologii; 4 / 2018 / vol. 7 Kosmetologia Estetyczna
Jacek Szepietowski, Monika Kapińska-Mrowiecka, Andrzej Kaszuba, Andrzej Langner, Waldemar Placek, Hanna Wolska; Trądzik zwyczajny: patogeneza i leczenie. Konsensus Polskiego Towarzystwa Dermatologicznego; Przegląd dermatologiczny 6/2012 vol. 99
Gabrielle Kosmoski, Dara Miller, Catherine Coret, Evren Atillasoy; A Topical Combination Regimen of Benzoyl Peroxide and Retinol Moisturizer for Mild to Moderate Acne; J Drugs Dermatol. 2022 Dec 1;21(12):1340-1346. doi: 10.36849/JDD.6845.
Laure Rittié 1, Gary J Fisher; UV-light-induced signal cascades and skin aging; Ageing Research Reviews Volume 1, Issue 4, September 2002, Pages 705-720
T C Roos 1, F K Jugert, H F Merk, D R Bickers; Retinoid metabolism in the skin; Pharmacol Rev 1998 Jun;50(2):315-33
Małgorzata Glenc-Ambroży, Laura Piejko; Retinoidy w profilaktyce fotostarzenia; 6 / 2020 / vol. 9 Aesthetic Cosmetology and Medicine
Prystowsky J. Topical retinoids. In: Se W (ed.). Comprehensive Dermatologie Drug Therapy. Philadelphia: Saunders, 2001.
Olsen EA, Katz HI, Levine N, et al. Tretinoin emollient cream for photodamaged skin: results of 48-week, multicenter, double-blind studies. J Am Acad Dermatol. 1997;37(2):217-226. doi:10.1016/s0190-9622(97)80128-4. Accessed 22.08.2020
Podlewski J. K., Chwalibogowska-Podlewska A.: Leki współczesnej terapii. Wydanie XVIII, Split Trading Sp. z. o. o., Warszawa 2007
Thielitz A., Abdel-Naser M. B., Fluhr J. W, Zouboulis C. C., Gollnick H.: Topical retinoids in acne – an evidence based overview. J Dtsch Dermatol Ges. 2008, 6: 1023–1031
Tadini K. A., Gaspar L. R., Maia Campos P. M.: Epidermal effects of tretinoin and isotretinoin: influence of isomerism. Pharmazie 2006, 61: 453–456
Goulden V., Stables G.I., Cunliffe W.J.: Prevalence of facial acne in adults. J Am Acad Dermatol 1999, 41, 577-580.
Christian F.P. Scholz, Mogens Kilian. The natural history of cutaneous propionibacteria, and reclassification of selected species within the genus Propionibacterium to the proposed novel genera Acidipropionibacterium gen. nov., Cutibacterium gen. nov. and Pseudopropionibacterium gen. nov. „International Journal of Systematic and Evolutionary Microbiology”. 66 (11), s. 4422–4432, 2016.
Paul S.YamauchiMD, PhDabDaliaRizkMDaNicholas J.LoweMD; Retinoid therapy for psoriasis; Dermatologic Clinics Volume 22, Issue 4, October 2004, Pages 467-476
Naiem T. Issa MD PhDa, Leon H. Kircik MD; Supplement Individual Article: A Reappraisal of Fixed-Combination Halobetasol Propionate and Tazarotene for the Treatment of Psoriasis: Biological Underpinnings, Therapeutic Mechanisms, and Economic Considerations; J Drugs Dermatol. 2023;22:1(Suppl 1):s3-10.
Duvic M, Nagpal S, Asano AT, Chandraratna RA. Molecular mechanisms of tazarotene action in psoriasis. J Am Acad Dermatol. 1997;37(2 Pt 3):S18-24
Weinstein GD, Koo JY, Krueger GG, et al. Tazarotene cream in the treatment of psoriasis: Two multicenter, double-blind, randomized, vehicle-controlled studies of the safety and efficacy of tazarotene creams 0.05% and 0.1% applied once daily for 12 weeks. J Am Acad Dermatol. 2003;48(5):760-767. doi: 10.1067/mjd.2003.103.
H Törmä 1, A Vahlquist; Vitamin A esterification in human epidermis: a relation to keratinocyte differentiation; J Invest Dermatol 1990 Jan;94(1):132-8. doi: 10.1111/1523-1747.ep12873990
Anna Bronikowska, Dorota Wojnowska;Zastosowanie retinoidów w dermatologii; Nowa Medycyna 1/2003
Stachurska E. , Ratajska A.; Retinoidy – ich metabolity, działanie i rola w rozwoju serca; Postępy Biochemii 2011 | 57 | 4 |
Alfred Zejc Maria Gorczyca; Chemia leków. Podręcznik dla studentów farmacji i farmaceutów; Wydawnictwo Lekarskie PZWL Rok wydania 2019
Chung J, Eun H. Angiogenesis in skin aging and photoaging. J Derm 2007, vol. 34: 593-600.
Wolbach SB, Howe PR. Tissue changes following deprivation of fat-soluble A vitamin. J Exp Med 1925; 42: 753-78.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Paulina Szczuraszek, Hugo Szczuraszek, Piotr Sałata, Michał Paluch, Michał Tomkiewicz, Julia Tomkiewicz, Magda Żuchnik, Gabriela Licak, Paulina Bętkowska, Agnieszka Rybkowska
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 1346
Number of citations: 0
