Study of the role of erythrocyte and leukocyte intoxication indexes in the pathogenesis of experimental peritonitis
DOI:
https://doi.org/10.12775/JEHS.2022.12.04.029Keywords
peritonitis, leukocyte index of intoxication, erythrocyte index of intoxication, pathogenesisAbstract
The article presents the results of studying the role of erythrocyte and leukocyte indices of intoxication in the pathogenesis of experimental peritonitis. When studying the role of erythrocyte and leukocyte indices, a unidirectional trend of their change was revealed. An increase in the erythrocyte index of intoxication in the pathogenesis of experimental fecal peritonitis was established, most pronounced on the 10th day of the experiment (the level of EII increased by 107% compared to intact animals). The results of the study of the leukocyte intoxication index indicate a unidirectional trend, as in the case of the erythrocyte intoxication index. On the first day, the leukocyte index of intoxication increased on 225% (р<0.05), on the 4th day – on 256.7% (р<0.05), and on the 10th day – on 260% (р <0.05) compared to intact animals. It has been proven that the leukocyte index of intoxication is a more sensitive marker compared to the erythrocyte index.
References
Andryushchenko V. P., Fedorenko S. T., Andryushchenko D. V. Acute purulent disseminated peritonitis: leading components of modern surgical tactics. Clinical analyst and operative surgeon. 2012. No. 11 (2). P. 91–93.
Clinical laboratory diagnostics: a study guide / B. D. Lutsik, L. E. Lapovets, G. B. Lebed, etc.; under the editorship B. D. Lutsyk. - 2nd edition. K.: Medicine, 2018. 288 p.
Lapach S. N., Chubenko A. V., Babich P. N. Statistical methods in medical and biological investigations with using Exel. К.: МORION, 2000. 320 p.
Endogenous intoxication syndrome in experimental peritonitis against the background of diabetes / I. Ya. Dzyubanovsky, B. M. Vervega, S. R. Pidruchna, N. A. Melnyk. Bulletin of scientific research. 2019. No. 1. P. 135–139.
Reznikov O. G., Solovyov A. I., Stefanov O. V. Biotic examination of preclinical and other scientific studies performed on animals: method. recommendations. Bulletin of pharmacology and pharmacy. 2006. Vol. 7. P. 47–61.
Lazarenko V. A., Lipatov V. A., Blinkov Yu. Yu., Skorikov D. V. Experimental model of widespread fecal peritonitis. Man and his health. 2008. No. 4. P. 128–132.
Ailabouni L. D., Kumar A. S. Laparoscopic Management of Fecal Peritonitis. Diseases of the colon and rectum. 2021. Vol. 64 (7). e395.
Clinicoepidemiological profile of peritonitis complicating acute peritoneal dialysis: A single-center experience / K. Gandhi, D. Prasad, V. Malhotra et al. Saudi journal of kidney diseases and transplantation. 2017. Vol. 28 (5). P. 1133–1137.
Delibgovic S. Pathophysiology of peritonitis. Veterinaria. 2022. Vol. 71 (2). P. 133–152.
Next-generation sequencing diagnostics of bacteraemia in septic patients / S. Grumaz, P. Stevens, C. Grumaz et al. Genome Med. 2016. Vol. 8. P. 1–13.
Novel pathomechanism for spontaneous bacterial peritonitis: disruption of cell junctions by cellular and bacterial proteases / M. Haderer, P. Neubert, E. Rinner et al. BMJ Journals. 2022. Vol. 71. P. 580–592.
Risk factors for peritoneal dialysis withdrawal due to peritoneal dialysis-related peritonitis / T. Banno, H. Shima, K. Kawahara et al. Nephrol Ther. 2021. Vol. 17 (2). P. 108–113.
Susan Yung, Tak Mao Chan. Pathophysiological changes to the peritoneal membrane during PD-Related peritonitis: the role of mesothelial cells. Mediators of Inflammation. 2012. Article. 484167. 21 p.
Weiss G., Schaible U. E. Macrophage defence mechanisms against intracellular bacteria. Immunological Reviews. 2015. Vol. 264 (1). P. 182–203.
Young-Taoli, Jiani-Rong Huang, Mei-Lian Peng. Current status and prospects on spontaneous peritonitis in patients with cirrhosis. BioMed Research International. 2020. Vol. 4. P. 1–12.
Savytskyi І. V., Mukhin O. M., Tsypoviaz S. V., Merza Y. M., Zashchuk R. G., Znamerovsky S. G., Badiuk N. S. Oxidative stress and lipid peroxidation in experimental peritonitis / PharmacologyOnLine; Archives - 2021 - vol.1 – 125-129.
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