Study of immunological activity and hemostasiological features in rats with experimental antiphospholipid syndrome
DOI:
https://doi.org/10.12775/JEHS.2022.12.02.038Keywords
antiphospholipid syndrome, pathogenesis, hemostasis, immunological activity, antibodiesAbstract
Antiphospholipid syndrome (APS) is a systemic autoimmune disease, which is characterized by thrombotic or obstetric events characterized by the presence in the blood of patients of a high titer of antibodies to natively charged membrane phospholipids, as well as to glycoproteins associated with them. The role of etiological factors, triggering mechanisms, especially at the initial stages of APS formation, is not clearly defined that’s why the aim of our work was to study of immunological activity and hemostasiological features in rats with experimental antiphospholipid syndrome. In animals with simulated APS, a positive microprecipitation reaction with cardiolipin antigen was observed, which indicated the development of APS. The development of hypercoagulation due to both the vascular and platelet and coagulation links of the hemostasis system was also noted. Established changes in hemocoagulation indicators in APS occur due to the interaction of blood clotting factors with APA.
References
Antiphospholipid syndrome: a case report with an unusual wide spectrum of clinical manifestations / C. Mazzoccoli, D. Comitangelo, A. D’introno et al. Autoimmunity Highlights. 2019. Vol. 10. e9.
Arterial thrombosis in antiphospholipid syndrome (APS): clinical approach and treatment / C. Cheng, G. Y. Cheng, G. Denas, V. Pengo. Blood reviews. 2021. Vol. 48. e100788.
Becarevic M. B., Nikolic B. S., Ignjatovic S. D. Adiponectin: a therapeutic target in the antiphospholipid syndrome? Rheumatology international. 2019. Vol. 39 (9). P. 1519–1525.
Cervera R., Rodriguez-Pinto I., Espinosa G. The diagnosis and clinical management of the catastrophic antiphospholipid syndrome: a comprehensive review. Journal of autoimmunity. 2018. Vol. 92. P. 1–11.
Chighizola C. B., Raimondo M. G., Meroni P. L. Management of thrombotic antiphospholipid syndrome. Seminars in thrombosis and hemostasis. 2018. Vol. 44 (5). P. 419–426.
Clinical and immunological features of antiphospholipid syndrome in the elderly: a retrospective national multicentre study / F. Grimaud, C. Yelnik, M. Pineton de Chambrun et al. Rheumatology. 2019. Vol. 58 (6). P. 1006–1010.
Bryndina I. G., Urakova M. A., Lebedeva N. V. Phospholipids of erythrocytes, blood plasma, surfactant and coagulation activity of the lungs in experimental antiphospholipid syndrome. Medical immunology. 2015. No. 5 (17). S. 122.
Radway-Bright E. L., Inane M., Isenberg D. A. Animal models of the antiphospholipid syndrome. Rheumatology. 1999. Vol. 38. P. 591–601.
Reznikov O. G., Solovyov A. I., Stefanov O. V. Biotic examination of preclinical and other scientific studies performed on animals: method. recommendations Herald of pharmacology and pharmacy. 2006. Vol. 7. P. 47–61.
Clinical laboratory diagnostics: a study guide / B. D. Lutsik, L. E. Lapovets, G. B. Lebed, etc.; under the editorship B. D. Lutsyk. - 2nd edition. K.: Medicine, 2018. 288 p.
Lapach S. N., Chubenko A. V., Babich P. N. Statistical methods in medical and biological investigations with using Exel. - К.: МORION, 2000. 320 p.
Clinical and therapeutic value of the adjusted Global Antiphospholipid Syndrome Score in primary obstetric antiphospholipid syndrome / S. Udry, S. M. Perez, C. Belizna et al. Lupus. 2022. Vol. 31 (3). P. 354–362.
Comparison of non-criteria antiphospholipid syndrome with definite antiphospholipid syndrome: A systematic review / G. Pires da Rosa, E. Ferreira, B. Sousa-Pinto et al. Frontiers Immunol. 2022. Vol. 13. 967178.
Galli M. Treatment of the antiphospholipid syndrome. Auto Immun Highlights. 2013. Vol. 5. P. 1–7.
Zepf F. D., Stewart R. M. Inflammation, immunity and suicidality: a potential role for autoantibodies against neurotransmitters and antiphospholipid syndrome? Acta psychiatrica Scandinavica. 2016. Vol. 133 (3). P. 249–250.
Yakymenko O. O., Savytskyi V. I., Klochko V. V., Savytskyi I. V., Mykhailiuk M. M., Gerasymenko T. V., Badiuk N. S. Dynamics of markers of endothelial dysfunction in experimental antiphospholipid syndrome / PharmacologyOnLine; Archives - 2021 - vol.1 – 74-81.
Yakymenko O. O., Savytskyi V. I., Klochko V. V., Savytskyi I. V., Badiuk N.S. Changes in vasoconstructor-vasodilation potential of vessels in experimental antiphospholipid syndrome / PharmacologyOnLine; Archives - 2021 - vol. 2 – 819-826
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 V. Savytskyi
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 203
Number of citations: 0