The molecular diagnosis of house dust mite allergy: a short review
DOI:
https://doi.org/10.12775/JEHS.2022.12.08.071Keywords
allergy, molecular diagnostics of allergy, allergen-specific E antibodies, asIgEAbstract
Introduction: House dust mite (HDM) allergens are considered among the most essential elicitors of allergic rhinitis and asthma worldwide [1]. How can we determine the individual sensitization profile of a patient? Is there a way to monitor the development of allergic symptoms? Is it possible to tailor different forms of therapy based on the individual sensitization profile of a patient?
Purpose: The study aims to show the benefits of molecular diagnostics of allergies based on the example of HDM allergy.
Description of the state of knowledge: Clinical manifestation is the most important aspect of diagnosing HDM allergy. The determination of allergen specific immunoglobulins E (asIgE) against HDM extracts may be helpful in the identification of the cause of allergy symptoms. However, the diagnosis using allergen extracts cannot be established in all cases. What revolutionised the diagnosing process of HDM allergy is the molecular diagnostics of allergy. Based on the presence of asIgE against allergen molecules it is possible to identify the allergen responsible for the sensitisation as well as personalise the therapeutic recommendations.
Summary: The molecular diagnostics of allergy significantly improved the specificity and sensitivity of HDM allergy diagnostics. Molecular diagnostics in individuals with HDM allergy make it possible to establish the individual patient’s allergy profile, and consequently personalise therapeutic recommendations. It is especially important regarding the selection of patients who may benefit from immunotherapy. The component-resolved diagnostics in allergology is a step toward personalised medicine.
References
Matricardi PM., et al. EAACI Molecular Allergology User's Guide. Pediatr Allergy Immunol, 2016: p. 1-250.
Jiménez-Feijoo, R., et al. Molecular Diagnosis in House Dust Mite-Allergic Patients Suggests That Der p 23 Is Clinically Relevant in Asthmatic Children. Journal of investigational allergology & clinical immunology, 2020. 30(2): p. 127-132.
Majsiak, E., et al. The prevalence of specific immunoglobulins E to inhalant allergens among Polish children and adults with suspicion of allergy. in ALLERGY. 2018. WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA.
Calderón, M.A., et al. Respiratory allergy caused by house dust mites: What do we really know? J Allergy Clin Immunol, 2015. 136(1): p. 38-48.
Rodinkova, V.V., et al. Molecular Profile Sensitization to House Dust Mites as an Important Aspect for Predicting the Efficiency of Allergen Immunotherapy. Front Immunol, 2022. 13: p. 848616.
Kleine-Tebbe J.,Jakob T. Molecular Allergy Diagnostics. Innovation for a Better Patient Management. Springer International Publishing Switzerland, 2017.
Hoffmann-Sommergruber, K., et al. Molecular Allergology User’s Guide 2.0. 2022, ©John Wiley & Sons A/S. Published by John Wiley & Sons Ltd: The European Academy of Allergy and Clinical Immunology (EAACI).
Molecular Allergology User’s Guide 2.0, K. Hoffmann, et al., Editors. 2022, The European Academy of Allergy and Clinical Immunology (EAACI): Switzerland.
Majsiak, E., et al., The first comparison of two multiparameter methods to measure specific immunoglobulin E among the Polish group of patients, in European Academy of Allergy and Clinical Immunology. 2019: Lisbon, Portugal, TP #1184.
Majsiak, E., et al. Molecular diagnostics - an innovative diagnostic tool in allergology. Laboratorium Medyczne, 2019. 4: p. 37-42.
González-Pérez, R., et al. House Dust Mite Precision Allergy Molecular Diagnosis (PAMD@) in the Th2-prone Atopic Dermatitis Endotype. Life (Basel), 2021. 11(12).
Weghofer, M., et al. Identification of Der p 23, a peritrophin-like protein, as a new major Dermatophagoides pteronyssinus allergen associated with the peritrophic matrix of mite fecal pellets. J Immunol, 2013. 190(7): p. 3059-67.
Skalicka-Woźniak, K.,E. Majsiak Geraniol - naturalne rozwiązanie w walce z roztoczami. Alergia 2, 24–26. Alergia, 2020. 2: p. 24-26.
Satinover, S.M., et al. Specific IgE and IgG antibody-binding patterns to recombinant cockroach allergens. J Allergy Clin Immunol, 2005. 115(4): p. 803-9.
Samoliński, B., et al. Korzyści jakie przynosi diagnostyka molekularna w rozpoznawaniu i leczeniu alergii. Alergia, 2019. 79(1): p. 33-40.
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Copyright (c) 2022 Magdalena Choina, Weronika Gromek, Klaudia Wilk, Magdalena Marzęda, Roman Pukaliak
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