Effect of mediterranean diet on non-alcoholic fatty liver disease (NAFLD)
DOI:
https://doi.org/10.12775/JEHS.2023.13.03.008Keywords
mediterranean diet, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (MASH)Abstract
Introduction and purpose of the work: Non-alcoholic fatty liver disease (NAFLD) is a common condition in the general population. In its course, excessive fatty acids are deposited in liver cells. The best way to prevent it is to reduce weight by being physically active and eating a proper low-calorie diet.
The purpose of this study is to describe the potential health benefits of the mediterranean diet in people with NAFLD. For this purpose, the literature available in the PubMed database was reviewed using the following keywords: mediterranean diet; non-alcoholic fatty liver disease (NAFLD); non-alcoholic steatohepatitis (MASH).
State of the knowledge: The mediterranean diet is rich in fruits, vegetables, nuts, fish, olive oil and whole-grain products. It has the effect of decreasing insulin resistance, which is a major cause of NAFLD. In addition, it exerts anti-inflammatory and antioxidant properties. In recent years, numerous clinical studies have been conducted analyzing the effects of this diet on laboratory results, liver steatosis and progression to steatohepatitis (MASH) in patients with NAFLD.
Conclusions: The results of the studies show that following a mediterranean diet can prevent as well as alleviate the course of this disease. However, there is a need for more clinical studies, on larger groups of people to recognize the mediterranean diet as an effective form of NAFLD therapy.
References
Younossi Z, Anstee QM, Marietti M et al. Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention. Nat Rev Gastroenterol Hepatol. 2018 Jan;15(1):11-20. doi: 10.1038/nrgastro.2017.109. Epub 2017 Sep 20.
Kelly T, Yang W, Chen CS et al. Global burden of obesity in 2005 and projections to 2030. Int J Obes (Lond). 2008 Sep;32(9):1431-7. doi: 10.1038/ijo.2008.102. Epub 2008 Jul 8.
Ratziu V, Bellentani S, Cortez-Pinto H et al. A position statement on NAFLD/NASH based on the EASL 2009 special conference. J Hepatol. 2010 Aug;53(2):372-84. doi: 10.1016/j.jhep.2010.04.008. Epub 2010 May 7.
Ekstedt M, Franzén LE, Mathiesen UL et al. Long-term follow-up of patients with NAFLD and elevated liver enzymes. Hepatology. 2006 Oct;44(4):865-73. doi: 10.1002/hep.21327.
Ratziu V, Bellentani S, Cortez-Pinto H et al. A position statement on NAFLD/NASH based on the EASL 2009 special conference. J Hepatol. 2010 Aug;53(2):372-84. doi: 10.1016/j.jhep.2010.04.008. Epub 2010 May 7.
Gelli C, Tarocchi M, Abenavoli L et al. Effect of a counseling-supported treatment with the Mediterranean diet and physical activity on the severity of the non-alcoholic fatty liver disease. World J Gastroenterol. 2017 May 7;23(17):3150-3162. doi: 10.3748/wjg.v23.i17.3150.
Abd El-Kader S.M., El-Den Ashmawy E.M. Non-alcoholic fatty liver disease: The diagnosis and management. World J. Hepatol. 2015;7:846–858. doi: 10.4254/wjh.v7.i6.846.
Abd El-Kader S.M., El-Den Ashmawy E.M.S. Non-Alcoholic Fatty Liver Disease: The Diagnosis and Management. World J. Hepatol. 2015;7:846–858. doi: 10.4254/wjh.v7.i6.846.
Bugianesi E., Moscatiello S., Ciaravella M.F., Marchesini G. Insulin resistance in nonalcoholic fatty liver disease. Curr. Pharm. Des. 2010;16:1941–1951. doi: 10.2174/138161210791208875.
Kirpich I.A., Marsano L.S., McClain C.J. Gut-liver axis, nutrition, and non-alcoholic fatty liver disease. Clin. Biochem. 2015;48:923–930. doi: 10.1016/j.clinbiochem.2015.06.023
Xu R, Tao A, Zhang S et al. Association between patatin-like phospholipase domain containing 3 gene (PNPLA3) polymorphisms and nonalcoholic fatty liver disease: a HuGE review and meta-analysis. Sci Rep. 2015 Mar 20;5:9284. doi: 10.1038/srep09284.
Del Ben M, Polimeni L, Baratta F, Pastori D, Loffredo L, Angelico F. Modern approach to the clinical management of non-alcoholic fatty liver disease. World J Gastroenterol. 2014;20:8341–8350.
European Association for the Study of the Liver (EASL); European Association for the Study of Diabetes (EASD); European Association for the Study of Obesity (EASO) EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease. J Hepatol. 2016;64:1388–1402
Sofi F, Macchi C, Abbate R et al. Mediterranean diet and health. Biofactors. 2013 Jul-Aug;39(4):335-42. doi: 10.1002/biof.1096. Epub 2013 Mar 29.
George E.S., Forsyth A., Itsiopoulos C., Nicoll A.J., Ryan M., Sood S., Roberts S.K., Tierney A.C. Practical Dietary Recommendations for the Prevention and Management of Nonalcoholic Fatty Liver Disease in Adults. Adv. Nutr. (Bethesda Md.) 2018;9:30–40. doi: 10.1093/advances/nmx007.
Urquiaga I, Echeverría G, Dussaillant C et al. [Origin, components and mechanisms of action of the Mediterranean diet]. Rev Med Chil. 2017 Jan;145(1):85-95. doi: 10.4067/S0034-98872017000100012.
Rivellese A.A., Giacco R., Annuzzi G., De Natale C., Patti L., Di Marino L., Minerva V., Costabile G., Santangelo C., Masella R., et al. Effects of monounsaturated vs. saturated fat on postprandial lipemia and adipose tissue lipases in type 2 diabetes. Clin. Nutr. 2008;27:133–141. doi: 10.1016/j.clnu.2007.07.005.
Abete I., Goyenechea E., Zulet M.A., Martinez J.A. Obesity and metabolic syndrome: Potential benefit from specific nutritional components. Nutr. Metab. Cardiovasc. Dis. 2011;21(Suppl. 2):1–15. doi: 10.1016/j.numecd.2011.05.001.
Ni Y., Zhuge F., Nagashimada M., Ota T. Novel Action of Carotenoids on Non-Alcoholic Fatty Liver Disease: Macrophage Polarization and Liver Homeostasis. Nutrients. 2016;8:391. doi: 10.3390/nu8070391.
Brand-Miller J.C., Holt S.H.A., Pawlak D.B., McMillan J. Glycemic index and obesity. Am. J. Clin. Nutr. 2002;76:281S–285S
Zadeh SH, Mansoori A, Hosseinzadeh M et al. Relationship between dietary patterns and non-alcoholic fatty liver disease: A systematic review and meta-analysis. J Gastroenterol Hepatol. 2021 Jun;36(6):1470-1478. doi: 10.1111/jgh.15363. Epub 2020 Dec 14.
Montemayor S, Mascaró CM, Ugarriza L et al. Adherence to Mediterranean Diet and NAFLD in Patients with Metabolic Syndrome: The FLIPAN Study. Nutrients. 2022 Aug 3;14(15):3186. doi: 10.3390/nu14153186.
Gelli C, Tarocchi M, Abenavoli L et al. Effect of a counseling-supported treatment with the Mediterranean diet and physical activity on the severity of the non-alcoholic fatty liver disease. World J Gastroenterol. 2017 May 7;23(17):3150-3162. doi: 10.3748/wjg.v23.i17.3150.
Asbaghi O, Choghakhori R, Ashtary-Larky D et al. Effects of the Mediterranean diet on cardiovascular risk factors in non-alcoholic fatty liver disease patients: A systematic review and meta-analysis. Clin Nutr ESPEN. 2020 Jun;37:148-156. doi: 10.1016/j.clnesp.2020.03.003. Epub 2020 Mar 19.
Kawaguchi T, Charlton M, Kawaguchi A et al. Effects of Mediterranean Diet in Patients with Nonalcoholic Fatty Liver Disease: A Systematic Review, Meta-Analysis, and Meta-Regression Analysis of Randomized Controlled Trials. Semin Liver Dis. 2021 Aug;41(3):225-234. doi: 10.1055/s-0041-1723751. Epub 2021 Jun 19.
Haigh L, Kirk C, Gendy KE et al. The effectiveness and acceptability of Mediterranean diet and calorie restriction in non-alcoholic fatty liver disease (NAFLD): A systematic review and meta-analysis. Clin Nutr. 2022 Sep;41(9):1913-1931. doi: 10.1016/j.clnu.2022.06.037. Epub 2022 Jul 2.
Cantero I, Abete I, Babio N et al. Dietary Inflammatory Index and liver status in subjects with different adiposity levels within the PREDIMED trial. Clin Nutr. 2018 Oct;37(5):1736-1743. doi: 10.1016/j.clnu.2017.06.027. Epub 2017 Jul 6.
Chiurazzi M, Cacciapuoti N, Di Lauro M et al. The Synergic Effect of a Nutraceutical Supplementation Associated to a Mediterranean Hypocaloric Diet in a Population of Overweight/Obese Adults with NAFLD. Nutrients. 2022 Nov 10;14(22):4750. doi: 10.3390/nu14224750.
Kontogianni MD, Tileli NT, Margariti A et al. Adherence to the Mediterranean diet is associated with the severity of non-alcoholic fatty liver disease. Clin Nutr. 2014 Aug;33(4):678-83. doi: 10.1016/j.clnu.2013.08.014. Epub 2013 Sep 7.
Schwingshackl L, Hoffmann G. Adherence to Mediterranean diet and risk of cancer: an updated systematic review and meta-analysis of observational studies. Cancer Med. 2015 Dec;4(12):1933-47. doi: 10.1002/cam4.539. Epub 2015 Oct 16.
Dominguez LI, Bella GD, Veronese N, Barbagallo M. Impact of Mediterranean Diet on Chronic Non-Communicable Diseases and Longevity. Nutrients. 2021 Jun 12;13(6):2028. doi: 10.3390/nu13062028.
Chatzi L, Rifas-Shiman SL, Georgiou V et al. Adherence to the Mediterranean diet during pregnancy and offspring adiposity and cardiometabolic traits in childhood. Pediatr Obes. 2017 Aug;12 Suppl 1(Suppl 1):47-56. doi: 10.1111/ijpo.12191. Epub 2017 Feb 3.
Bach-Faig A., Berry E.M., Lairon D., Reguant J., Trichopoulou A., Dernini S., Medina F.X., Battino M., Belahsen R., Miranda G., et al. Mediterranean diet pyramid today. Science and cultural updates. Public Health Nutr. 2011;14:2274–2284. doi: 10.1017/S1368980011002515.
Nakano H, Wu S, Sakao K et al. Bilberry Anthocyanins Ameliorate NAFLD by Improving Dyslipidemia and Gut Microbiome Dysbiosis. Nutrients. 2020 Oct 23;12(11):3252. doi: 10.3390/nu12113252.
Pani A, Giossi R, Menichelli D et al. Inositol and Non-Alcoholic Fatty Liver Disease: A Systematic Review on Deficiencies and Supplementation. Nutrients. 2020 Nov 3;12(11):3379. doi: 10.3390/nu12113379.
George ES, Reddy A, Nicoll AJ et al. Impact of a Mediterranean diet on hepatic and metabolic outcomes in non-alcoholic fatty liver disease: The MEDINA randomised controlled trial. Liver Int. 2022 Jun;42(6):1308-1322. doi: 10.1111/liv.15264. Epub 2022 Apr 26.
Argo CK, Patrie JT, Lackner C et al. Effects of n-3 fish oil on metabolic and histological parameters in NASH: a double-blind, randomized, placebo-controlled trial. J Hepatol. 2015 Jan;62(1):190-7. doi: 10.1016/j.jhep.2014.08.036. Epub 2014 Sep 6.
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Copyright (c) 2023 Patrycja Walczak, Klaudia Walczak, Sylwia Zdun, Sylwia Nemeczek, Konrad Merkisz, Jakub Grzybowski, Agnieszka Marciniak, Natalia Grzywna, Karolina Jaskuła, Władysław Orłowski
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