Reduction of mineralizing activity of periodontal bone tissue in rats with consumption of ordinary sunflower oil
DOI:
https://doi.org/10.12775/JEHS.2022.12.12.049Keywords
osteoporosis, bone mineralizing activity, periodontal disease, sunflower oil, ω-3 LCPUFAAbstract
More than 20 % of people over the age of 50 suffer from osteoporosis. Lipids play an important role in the pathogenesis of osteoporosis.
Background. To investigate the effect of ordinary (high-linoleic) sunflower oil (OSO) on the state of periodontal bone tissue.
Methods. In 5 series of experiments, determine the mineralization activity of the alveolar appendix of the mandible rats that were obtained with feed 5 or 15 percent of OSO for from 22 to 75 days. Mineralizing activity was determined by the ratio of activity of alkaline and acid phosphatase. In liver lipids (fractions of phospholipids and free fatty acids) were determined by the content of long-chain polyunsaturated fatty acids (LCPUFA) by the gas chromatographic method.
Results. A decrease in mineralizing activity in OSO consumption, especially when using a feed with 15 % of OSO against a dysbiosis or metabolic syndrome. A significant (almost 10 times) is shown to reduce the content of ω-3 PUFA in fraction of phospholipids of the liver of rats receiving a diet with a content of OSO.
Conclusion. Sunflower oil reduces the mineralizing activity of periodontal bone tissue by reducing the endogenous biosynthesis of ω-3 PUFA.
References
Levitsky AP, Egorov BV, Lapinskaya AP, Selivanskaya IA. Inadequate fat diet. Journal of Education, Health and Sport. 2020;10(7):248-255. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2020.10.07.029
Levitsky AP. Fried butter: benefit or harm? Scientific and practical manual. ‒ Odessa: Ecology, 2021:42. (in Russian)
Titov VN, Lisitsyn DM. Regulation of peroxidation in vivo as a stage of inflammation. Oleic acid, reactive oxygen species invaders and antioxidants // Clinical laboratory diagnostics.2005;6:3-12. (in Russian)
Zheng CJ, Yoo J-S, Lee T-G [and others]. Fatty acid synthesis is a target for antibacterial activity of unsaturated fatty acids. FEBS Lett. 2005;579(23):5157-62. doi: 10.1016/j.febslet.2005.08.028.
Santacruz A, Marcos A, Wärnberg J [and others]. Interplay between weight loss and gut microbiota composition in overweight adolescents. Obesity (Silver Spring). 2009;17(10):1906-1915. doi: 10.1038/oby.2009.112.
Markov AV, Labush IuZ, Khodakov IV [and others]. Influence of oral fatty applications on biochemical indicators of inflammation and dysbiosis in the tissues of the rat mouth. Journal of Education, Health and Sport. 2018;8(10):392-404. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1889334
Levitsky A. P., Gozhenko A. I., Selivanskaya I. A., Lapinskaya A. P., Tomilina T. V., Badiuk N. S. Therapeutic and prophylactic efficiency of polyfunctional anti-disbiotic drugs under conditions of experimental lipid intoxication / PharmacologyOnLine; Archives - 2021 - vol.1 - 47-52.
Tian L, Yu X. Lipid metabolism disorders and bone dysfunction - interrelated and mutually regulated (Review). Mol.Med.Rep. 2015; 12: 783-794. https://doi.org/10.3892/mmr.2015.3472
Aurora R. Confounding factors in the effect of gut microbiota on bone density. Rheumatology (Oxford). 2019;58(12):2089-2090. doi: 10.1093/rheumatology/kez347.
Florencio-Silva R, Sasso GR, Sasso-Cerri E [and others]. Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells. Biomed.res.int.2015;421746. https://doi.org/10.1155/2015/421746
Levitsky AP, Makarenko OA, Khodakov IV [and others]. Enzymatic method for assessing the quality of bone tissue. Odessa Medical Journal. 2006;3: 17-21. (n Ukrainian)
Levitsky AP, Makarenko OA, Demyanenko SA. Methods of experimental dentistry. Simferopol: Tarpan, 2018:78. (in Russian)
Khodakov IV, Tkachuk VV, Velichko VI [and others]. Fatty acid composition of lipids in the liver of rats treated with palm oil and lincomycin. Bulletin of Marine Medicine. 2017;1(74):145-152. (in Russian)
Khodakov IV. Methods of identification and determination of the content of the components of the fat mixture. Detection of falsification of fats and oils: guidelines. Odessa, 2019:92. (in Russian)
Schneider SA, Levitsky AP. Experimental dentistry. Part I. Experimental models of dental diseases. Odessa, 2017:168. (in Russian)
Khodakov IV, Makarenko OA, Khromagina LN [and others]. The use of the essential fatty acid preparation “Liposan-forte” against the background of long-term administration of prednisolone to white rats. Bulletin of Dentistry. 2020;38 4(113):9-16. (in Russian)
Sepelveda MR, Berrocal-Carrito MB, Gasset M [and others]. The plasma membrane Ca2+-ATPase isoform 4 is localized in lipid rafts of cerebellum synaptic plasma membranes. J.Biol.Chem. 2006;281:447-453.
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