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Journal of Education, Health and Sport

Reduction of mineralizing activity of periodontal bone tissue in rats with consumption of ordinary sunflower oil
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  • Reduction of mineralizing activity of periodontal bone tissue in rats with consumption of ordinary sunflower oil
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Reduction of mineralizing activity of periodontal bone tissue in rats with consumption of ordinary sunflower oil

Authors

  • A. Levitsky Odesa National Academy of Food Technologies
  • T. Pupin Danylo Halytsky Lviv National Medical University
  • I. Selivanskaya Odessa National Medical University
  • A. Lapinskaya Odesa National Academy of Food Technologies
  • A. Markov Danylo Halytsky Lviv National Medical University

DOI:

https://doi.org/10.12775/JEHS.2022.12.12.049

Keywords

osteoporosis, bone mineralizing activity, periodontal disease, sunflower oil, ω-3 LCPUFA

Abstract

More than 20 % of people over the age of 50 suffer from osteoporosis.  Lipids play an important role in the pathogenesis of osteoporosis.

Background. To investigate the effect of ordinary (high-linoleic) sunflower oil (OSO) on the state of periodontal bone tissue.

Methods. In 5 series of experiments, determine the mineralization activity of the alveolar appendix of the mandible rats that were obtained with feed 5 or 15 percent of OSO for from 22 to 75 days. Mineralizing activity was determined by the ratio of activity of alkaline and acid phosphatase. In liver lipids (fractions of phospholipids and free fatty acids) were determined by the content of long-chain polyunsaturated fatty acids (LCPUFA) by the gas chromatographic method.

Results. A decrease in mineralizing activity in OSO consumption, especially when using a feed with 15 % of OSO against a dysbiosis or metabolic syndrome. A significant (almost 10 times) is shown to reduce the content of ω-3 PUFA in fraction of phospholipids of the liver of rats receiving a diet with a content of OSO.

Conclusion. Sunflower oil reduces the mineralizing activity of periodontal bone tissue by reducing the endogenous biosynthesis of ω-3 PUFA.

References

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Zheng CJ, Yoo J-S, Lee T-G [and others]. Fatty acid synthesis is a target for antibacterial activity of unsaturated fatty acids. FEBS Lett. 2005;579(23):5157-62. doi: 10.1016/j.febslet.2005.08.028.

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Levitsky A. P., Gozhenko A. I., Selivanskaya I. A., Lapinskaya A. P., Tomilina T. V., Badiuk N. S. Therapeutic and prophylactic efficiency of polyfunctional anti-disbiotic drugs under conditions of experimental lipid intoxication / PharmacologyOnLine; Archives - 2021 - vol.1 - 47-52.

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Florencio-Silva R, Sasso GR, Sasso-Cerri E [and others]. Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells. Biomed.res.int.2015;421746. https://doi.org/10.1155/2015/421746

Levitsky AP, Makarenko OA, Khodakov IV [and others]. Enzymatic method for assessing the quality of bone tissue. Odessa Medical Journal. 2006;3: 17-21. (n Ukrainian)

Levitsky AP, Makarenko OA, Demyanenko SA. Methods of experimental dentistry. Simferopol: Tarpan, 2018:78. (in Russian)

Khodakov IV, Tkachuk VV, Velichko VI [and others]. Fatty acid composition of lipids in the liver of rats treated with palm oil and lincomycin. Bulletin of Marine Medicine. 2017;1(74):145-152. (in Russian)

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Schneider SA, Levitsky AP. Experimental dentistry. Part I. Experimental models of dental diseases. Odessa, 2017:168. (in Russian)

Khodakov IV, Makarenko OA, Khromagina LN [and others]. The use of the essential fatty acid preparation “Liposan-forte” against the background of long-term administration of prednisolone to white rats. Bulletin of Dentistry. 2020;38 4(113):9-16. (in Russian)

Sepelveda MR, Berrocal-Carrito MB, Gasset M [and others]. The plasma membrane Ca2+-ATPase isoform 4 is localized in lipid rafts of cerebellum synaptic plasma membranes. J.Biol.Chem. 2006;281:447-453.

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Published

2022-12-21

How to Cite

1.
LEVITSKY, A., PUPIN, T., SELIVANSKAYA, I., LAPINSKAYA, A. & MARKOV, A. Reduction of mineralizing activity of periodontal bone tissue in rats with consumption of ordinary sunflower oil. Journal of Education, Health and Sport [online]. 21 December 2022, T. 12, nr 12, s. 323–330. [accessed 31.3.2023]. DOI 10.12775/JEHS.2022.12.12.049.
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Vol. 12 No. 12 (2022)

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Research Articles

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Copyright (c) 2022 A. Levitsky, T. Pupin, I. Selivanskaya, A. Lapinskaya, A. Markov

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

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