Features of the system of antioxidant protection and lipid peroxidation in microangiopathies against type 2 diabetes mellitus
DOI:
https://doi.org/10.12775/JEHS.2020.10.10.039Keywords
antioxidant system, diabetes mellitus, diabetic retinopathy, diabetic nephropathy, lipid peroxidationAbstract
The article presents the results of an experimental study of the AOР and LPО system in animals simulated complications of the microcirculatory tract (diabetic retinopathy, diabetic nephropathy) on the background of type 2 diabetes. It was found that in the group of animals with type 2 diabetes increased the level of DC, TBCproducts and MDA; catalase and FG levels decreased. In animals with simulated DN, AOP disorders were more pronounced compared to animals with DR. This trend can be explained by the fact that in addition to hyperglycemia in these animals, the excessive formation of free radicals contributes to metabolic shifts in ischemic areas of tissues and organs. Disturbance of balance in AOP and LPO in type 2 diabetes triggers a pathogenetic cascade of development of complications of the microcirculatory tract and is accompanied by a tendency to further increase the generation of reactive oxygen species and activation of POL in microangiopathies.
References
Bayrasheva VK Modeling of diabetes mellitus and diabetic nephropathy in experiment. Modern problems of science and education. 2015. No. 4. https://www.scienceeducation.ru/ru/article/view?id=21024
Biological significance of the system of antioxidant protection of the animal body / Yu. Yu. Lavryshyn et al. Scientific Bulletin of LNUVMBT named after SZ Gzhytsky. 2016. Vol. 18, № 2 (66). P. 100–111.
Biomarkers of diabetic retinopathy / M. V. Budzinskaya, D. V. Lipatov, V. G. Pavlov, D. V. Petrachkov // Diabetes mellitus. 2020. No. 1 (23). S. 88–94.
Study of antioxidant properties of thick bean extract on the model of type 2 diabetes on the background of obesity rats / V.A. Rybak, L.M. Maloshtan, V.V. Poltorak, N.S. Krasova // Pharmacology and drug toxicology. 2015. Vol. 1 (42). P. 76–81.
Preclinical studies of drugs: a method. reccom. / for ed. Corresponding Member NAMS of Ukraine, acad. O.V. Stefanova. Avicenna, 2001.528 p.
Methods of statistical processing of medical data: method. rivers. / A.G. Kochetov, O. V. Lyang, I. V. Zhirov et al. M .: RKNPK, 2012.42 p.
Menshikov V.V. Laboratory research methods in the clinic. M .: Medicine, 1987. 368 p.
Mokriy V.Ya., Zyablitsev S.V., Kryshtal M.V. Peculiarities of oxidative stress formation in patients with type 2 diabetes mellitus depending on the duration of the disease and sex. International Journal of Endocrinology. 2016. Vol. 5 (77). P. 67–71.
Popova TN, Agarkov AA, Verevkin AN Intensity of free radical processes in the liver of rats with type 2 diabetes mellitus and the introduction of epiphamine. Experimental articles. 2013. Vol. 4 (19). P. 129–134.
Reznikov O.G., Solovyov A.I., Stefanov O.V. Biotic examination of preclinical and other scientific studies performed on animals: a method. recommendations. Bulletin of Pharmacology and Pharmacy. 2006. Vol. 7. P. 47–61.
Stalnaya I.D., Garishvili T.G. Method for the determination of malonic dialdehyde using thiobarbituric acid. Modern methods in biochemistry. M .: Medicine, 1977. P. 66–68.
Diabetic microangiopathy: Pathogenetic insights and novel therapeutic approaches / R. Madonna et al. Vascul Pharmacol. 2017. Vol. 90. Р. 1–7.
Dymkowska D. Oxidative damage of the vascuar endothelium in type 2 diabetes – the role of mitochondria and NAD(P)H oxidase. Postepy Biochem. 2016. Vol. 62 (2). Р. 116–126.
Gozhenko A. I., Levitsky A. P., Stepan V. T., Pustovoit I. P., Badiuk N. S., Maslyukov A. K. Advantages of high olein sunflower oil over palm oil according to biochemical research results / - PhOL – PharmacologyOnLine – 2020. - Vol. 2. - P. 293-301.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2020 I. Savitsky, I. Gritsan, V. Sarakhan, Ya. Sirman, N. Preys
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 193
Number of citations: 0
