Sexual dimorphism in relationships between of plasma bilirubin and some neuro-endocrine parameters
Keywordsplasma bilirubin, cortisol, testosterone, aldosterone, triiodothyronine, calcitonin, ongoing EEG, HRV, anxiety, men, women
Background. Earlier we found that plasma uric acid, urea and creatinine causes modulating effects on neuro-endocrine parameters, as well as anxiety, but these effects are significantly different in men and women of different ages. The purpose of this study is to analyze the relationships between the plasma bilirubin level and some psycho-neuro-endocrine parameters in the same cohort. Materials and Methods. The object of observation were almost healthy volunteers: 31 males (24÷69 y) and 30 females, from among them 18 postmenopausal (48÷76 y) and 12 of reproductive age (30÷45 y). In basal conditions we determined plasma levels of bilirubin and adaptation hormones, estimated the severity of the trait and reactive anxiety, recorded the ongoing HRV and EEG. After 4 or 7 days, repeated testing was performed. Results. By building regression models with stepwise exclusion, it was found that in men plasma bilirubin upregulates the variability of β- and α-rhythms as well as PSD of β-rhythm in T4 and Fp2 loci, but downregulates the variability of θ-rhythm, PSD of β-rhythm in P4 and δ-rhythm in T6 loci as well as the trait anxiety. The measure of determination is 42,6% In postmenopausal women, bilirubin downregulates the PSD of β-rhythm in T6 locus, but upregulates the Testosterone plasma level, vagal tone as well as PSD of ULF and VLF bands HRV. The degree of determination of neuro-endocrine parameters is 59,2%. In women of reproductive age bilirubin upregulates the PSD of β-rhythm in T4 locus while downregulates the amplitude of θ- and β-rhythms, PSD of β-rhythm in 5 loci, of α-rhythm in 5 other loci as well as the Entropy of EEG in T5, P4 and C4 loci. The degree of determination of EEGs parameters is 97,8%. Conclusion. Plasma bilirubin has a modulating effect on psycho-neuro-endocrine parameters, but this effect is significantly different in men and women of different ages, which is due, apparently, to the influence of sex hormones on the expression of Ah receptors in neurons.
Akselrod S, Gordon D, Ubel FA, Shannon DC, Barger AC, Cohen RJ. Pоwer spectrum analysis rate fluctuation: a quantitative probe of beat-to-beat cardiovascular control. Science (NY). 1981; 213(4504): 220-222.
Baevskiy RM, Ivanov GG. Heart Rate Variability: theoretical aspects and possibilities of clinical application. Ultrazvukovaya i funktsionalnaya diagnostika. 2001; 3: 106-127. [in Russian].
Berntson GG, Bigger JT jr, Eckberg DL, Grossman P, Kaufman PG, Malik M, Nagaraja HN, Porges SW, Saul JP, Stone PH, Van der Molen MW. Heart Rate Variability: Origines, methods, and interpretive caveats. Psychophysiology. 1997; 34: 623-648.
Bombushkar IS, Gozhenko AI, Badiuk NS, Smagliy VS, Korda MM, Popovych IL, Blavatska OM. Relationships between parameters of uric acid metabolism and neuro-endocrine factors of adaptation [in Ukrainian]. Herald of marine medicine. 2022; 2(95): 59-74.
Bombushkar IS, Gozhenko AI, Korda MM, Żukow X, Popovych IL. Relationships between plasma levels of nitrogenous metabolites and some psycho-neuro-endocrine parameters. Journal of Education, Health and Sport. 2022; 12(6): 365-383.
Bombushkar IS, Korda MM, Gozhenko AI, Żukow X, Popovych IL. Psycho-neuro-endocrine accompaniments of individual variants of nitrogenous metabolites exchange. Journal of Education, Health and Sport. 2022; 12(7): 994-1008.
Bombushkar IS, Anchev AS, Żukow X, Popovych IL. Sexual dimorphism in relationships between of plasma urea and some psycho-neuro-endocrine parameters Journal of Education, Health and Sport. 2022; 12(8): 1198-1205.
Bombushkar IS, Anchev AS, Żukow X, Popovych IL. Sexual dimorphism in relationships between of plasma creatinine and some neuro-endocrine parameters. Journal of Education, Health and Sport. 2022; 12(9): 985-997.
Dani C, Pratesi S, Ilari A, Lana D, Giovannini MG, Nosi D, Buonvicino D, Landucci E, Bani D, Mannaioni G, Gerace E, et al. Neurotoxicity of Unconjugated Bilirubin in Mature and Immature Rat Organotypic Hippocampal Slice Cultures. Neonatology. 2019; 115(3): 217-225.
Goryachkovskiy АМ. Clinical Biochemistry. Odesa. Astroprint; 1998: 608. [in Russian].
Gozhenko AI, Zukow W, Polovynko IS, Zajats LM, Yanchij RI, Portnichenko VI, Popovych IL. Individual Immune Responses to Chronic Stress and their Neuro-Endocrine Accompaniment. RSW. UMK. Radom. Torun; 2019: 200.
Gozhenko АІ, Korda MM, Popadynets’ OO, Popovych IL. Entropy, Harmony, Synchronization and their Neuro-endocrine-immune Correlates [in Ukrainian]. Odesa. Feniks; 2021: 232.
Heart Rate Variability. Standards of Measurement, Physiological Interpretation, and Clinical Use. Task Force of ESC and NASPE. Circulation. 1996; 93(5): 1043-1065.
Kimura E, Tohyama C. Embryonic and Postnatal Expression of Aryl Hydrocarbon Receptor mRNA in Mouse Brain. Front Neuroanat. 2017; 11: 4.
Korda MM, Gozhenko AI, Kuchma IL, Korda IV, Popadynets’OO, Badiuk NS, Korolyshyn TA, Zukow W, Popovych IL. Normal bilirubinemia downregulates the power spectral density of the θ and δ rhythm, instead upregulates the β rhythm and sympatho-vagal balance in adult humans. Journal of Education, Health and Sport. 2022; 12(1): 454-472.
Ojo ES, Tischkau SA. The Role of AhR in the Hallmarks of Brain Aging: Friend and Foe. Cells. 2021; 10(10): 2729.
Phelan D, Winter GM, Rogers WJ, Lam JC, Denison MS. Activation of the Ah receptor signal transduction pathway by bilirubin and biliverdin. Arch Biochem Biophys. 1998; 357(1): 155-163.
Practical psychodiagnostics. Techniques and tests [in Russian]. Samara. Bakhrakh; 1998: 59-64.
Popovych IL, Gozhenko AI, Bombushkar IS, Korda MM, Zukow W. Sexual dimorphism in relationships between of uricemia and some psycho-neuro-endocrine parameters. Journal of Education, Health and Sport. 2015; 5(5): 556-581.
Popovych IL, Gozhenko AI, Korda MM, Klishch IM, Popovych DV, Zukow W (editors). Mineral Waters, Metabolism, Neuro-Endocrine-Immune Complex. Odesa. Feniks; 2022: 252.
Shannon CE. A mathematical theory of information. Bell Syst Tech J. 1948; 27: 379-423.
Shaffer F, Ginsberg JP. An Overview of Heart Rate Variability Metrics and Norms. Front Public Health. 2017; 5: 258.
Spielberger CD. Manual for the State-Trait Anxiety Inventory (Form Y) Consulting Psychologists Press; Palo Alto (CA): 1983.
Taylor JA, Carr DL, Myers CW, Eckberg DL. Mechanisms underlying very-low-frequency RR-interval oscillations in humans. Circulation. 1998; 98(6): 547-555.
Theorell T, Liljeholm-Johansson Y, Björk H, Ericson M. Saliva testosterone and heart rate variability in the professional symphony orchestra after "public faintings" of an orchestra member. Psychoneuroendocrinology. 2007; 32(6): 660-668.
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