The endocrine background of meningioma carcinogenesis
DOI:
https://doi.org/10.12775/JEHS.2023.13.02.028Keywords
meningioma, female sex hormones, adipokines, ACTH, congenital adrenal hyperplasia, neurosurgery, endocrinologyAbstract
Meningiomas, being mostly benign tumors, are derived from the arachnoid cap cells, their etiopathogenesis is based on various factors. The etiology of sporadic meningiomas is not yet known. Many factors have been identified as possible causes of the development of intracranial meningiomas. These include head trauma, viral infections, deletion in the NF2 gene, the use of cell phones, and sex hormones. The review is based on a endocrine factors, playing a role in meningioma carcinogenesis.
The carcinogenesis of meningioma appeals to be profoundly dependent from hormonal factors. Mayor ones, usually underlined in according to their prognostic significance, are female sex hormones. Due to this, meningiomas are twice as more likely to occur in female than in male patients. The other group of hormones appointed to play a role in meningioma carcinogenesis are adipokines in general – and leptin in particular. Leptin secretion correlates with BMI elevation, what may explain the confirmed linking between obesity and brain tumors. The scientific literature has documented the occurrence of meningioma in five patients with CAH, but the role of cortical axis and/or ACTH secretion impairments is still under consideration. Authors didn’t find any publication about the role of thyroid disorders in meningioma carcinogenesis.
The carcinogenesis of meningioma appeals to be profoundly dependent from hormonal factors. The effects of female sex hormones and adipokines are under a significant consideration, and may be useful in severity prediction. Basic science research should be focused on ACTH secretion in meningioma and possible common genetic etiopathogenesis of meningioma and CAH.
References
Alfredo Quinones-Hinojosa. Schmidek and Sweet: Operative Neurosurgical Techniques. 7th edition. 2022.
Gatson NTN, Boccia ML, Taylor KR, Mack JKO, Fonkem E. Hormone-Dependent Tumors and Sexuality in the Neuro-Oncology of Women (N.O.W.): Women’s Brain Tumors, Gaps in Sexuality Considerations, and a Need for Evidence-Based Guidelines. Curr Oncol Rep. 2021;23(11). doi:10.1007/S11912-021-01115-W.
Marosi C, Hassler M, Roessler K, Reni M, Sant M, Mazza E, et al. Meningioma. Crit Rev Oncol Hematol. 2008;67(2):153–171.
Kuroi Y, Matsumoto K, Shibuya M, Kasuya H. Progesterone Receptor Is Responsible for Benign Biology of Skull Base Meningioma. World Neurosurg. 2018;118:e918–e924.
Poniman J, Cangara MH, Kaelan C, Miskad UA, Arsyadi G, Ghaznawe M, et al. Progesterone Receptor Expression and Score Differences in Determining Grade and Subtype of Meningioma. J Neurosci Rural Pract. 2020;11(4):552–557.
Wang D, Sadek AR, Vaseeharan S, Manivannan S, Walker M, Nader-Sepahi A. Presentation and management of spinal meningioma and its association with breast carcinoma-case series and systematic review. Br J Neurosurg. 2022. doi:10.1080/02688697.2022.2061419.
Modzelewska P, Chludzińska S, Lewko J, Reszeć J. The influence of leptin on the process of carcinogenesis. Contemp Oncol (Pozn). 2019;23(2):63–68.
Sergentanis TN, Tsivgoulis G, Perlepe C, Ntanasis-Stathopoulos I, Tzanninis IG, Sergentanis IN, et al. Obesity and Risk for Brain/CNS Tumors, Gliomas and Meningiomas: A Meta-Analysis. PLoS One. 2015;10(9). doi:10.1371/JOURNAL.PONE.0136974.
Komarowska M, Chrzanowski R, Tylicka M, Rutkowski R, Mariak Z, Zelazowska-Rutkowska B, et al. Plasma concentration of Bisphenol A and leptin in patients with meningioma and glioma: A pilot study. Adv Med Sci. 2022;67(2):229–233.
Wang Y, Sun Z, Jiang Z. Cushing’s Disease Caused by a Pituitary Microadenoma Coexistent with a Meningioma: A Case Report and Literature Review. Int J Gen Med. 2020;13:1243–1248.
Phuphanich S, Jacobs L, Poulos JE, Vesely DL. Hypoglycemia Secondary to a Meningioma. Am J Med Sci. 1995;309(6):317–321.
Strumph PS, Stechison MT, Lee PA. Meningioma in congenital adrenal hyperplasia. Endocr Pract. 1995;1(3):161–162.
List MA, Edwards K, Chen S. Giant Meningioma in a Patient With Congenital Adrenal Hyperplasia. Otol Neurotol. 2021;42(2):e237–e239.
Heijboer AC, Netelenbos JC, Blankenstein MA. Meningioma in untreated congenital adrenal hyperplasia: a relationship? J Neurooncol. 2009;92(2):223–225.
O’Shea T, Crowley RK, Farrell M, MacNally S, Govender P, Feeney J, et al. Growth of a progesterone receptor-positive meningioma in a female patient with congenital adrenal hyperplasia. Endocrinol Diabetes Metab Case Rep. 2016;2016. doi:10.1530/EDM-16-0054.
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