Sexual dimorphism in relationships between of plasma urea and some psycho-neuro-endocrine parameters
Keywordsplasma urea, cortisol, testosterone, aldosterone, triiodothyronine, calcitonin, ongoing EEG, HRV, anxiety, men, women
Background. Earlier we found a strong urato-neural relationships in both men and women. Moreover, in women, the factor structure of the neural root is almost completely different from that in men. In addition, significant differences were found between the profiles of urato-neural correlations of women of reproductive age and postmenopausal women. The purpose of this study is to analyze the relationships between the plasma urea level and some psycho-neuro-endocrine parameters in the same cohort. Materials and Methods. The object of observation were almost healthy volunteers: 31 males (24÷69 y) and 30 females, from among them 18 postmenopausal (48÷76 y) and 12 of reproductive age (30÷45 y). In basal conditions we determined plasma levels of urea and adaptation hormones, estimated the severity of the trait and reactive anxiety, recorded the ongoing HRV and EEG. After 4 or 7 days, repeated testing was performed. Results. By building regression models with stepwise exclusion, it was found that in men plasma urea positively determines (R2=0,499) the level of circulating catecholamines and power spectrum density (PSD) of δ-, θ- and β-rhythms in different loci. In postmenopausal women, urea downregulates the amplitude and PSD of δ-rhythm in different loci, instead, it upregulates the PSD of α-rhythm in T5 locus, entropy of EEG in 2 loci and vagal tone. The degree of determination of neural parameters is 71,6%. In women of reproductive age the degree of determination of neural parameters is similar (69,9%), but the factor structure of the model is completely different. Urea upregulates the PSD of β-rhythm in F7 locus while downregulates the levels of reactive anxiety, vagal tone, entropy of EEG in 3 loci and P4-θ PSD as well as causes left lateralization of θ- and α-rhythms. Conclusion. Plasma urea has a modulating effect on EEG&HRV parameters, as well as reactive anxiety, but this effect is significantly different in men and women of different ages.
Baevskiy RM, Ivanov GG. Heart Rate Variability: theoretical aspects and possibilities of clinical application. Ultrazvukovaya i funktsionalnaya diagnostika. 2001; 3: 106-127. [in Russian].
Berntson GG, Bigger JT jr, Eckberg DL, Grossman P, Kaufman PG, Malik M, Nagaraja HN, Porges SW, Saul JP, Stone PH, Van der Molen MW. Heart Rate Variability: Origines, methods, and interpretive caveats. Psychophysiology. 1997; 34: 623-648.
Bombushkar IS, Gozhenko AI, Badiuk NS, Smagliy VS, Korda MM, Popovych IL, Blavatska OM. Relationships between parameters of uric acid metabolism and neuro-endocrine factors of adaptation [in Ukrainian]. Herald of marine medicine. 2022; 2(95): 59-74.
Bombushkar IS, Gozhenko AI, Korda MM, Żukow X, Popovych IL. Relationships between plasma levels of nitrogenous metabolites and some psycho-neuro-endocrine parameters. Journal of Education, Health and Sport. 2022; 12(6): 365-383.
Bombushkar IS, Korda MM, Gozhenko AI, Żukow X, Popovych IL. Psycho-neuro-endocrine accompaniments of individual variants of nitrogenous metabolites exchange. Journal of Education, Health and Sport. 2022; 12(7): 994-1008.
Goryachkovskiy АМ. Clinical Biochemistry. Odesa. Astroprint; 1998: 608. [in Russian].
Gozhenko AI. Essays on disease theory [in Russian]. Odesa; 2010: 24.
Gozhenko AI, Zukow W, Polovynko IS, Zajats LM, Yanchij RI, Portnichenko VI, Popovych IL. Individual Immune Responses to Chronic Stress and their Neuro-Endocrine Accompaniment. RSW. UMK. Radom. Torun; 2019: 200.
Gozhenko АІ, Korda MM, Popadynets’ OO, Popovych IL. Entropy, Harmony, Synchronization and their Neuro-endocrine-immune Correlates [in Ukrainian]. Odesa. Feniks; 2021: 232.
Heart Rate Variability. Standards of Measurement, Physiological Interpretation, and Clinical Use. Task Force of ESC and NASPE. Circulation. 1996; 93(5): 1043-1065.
Kerdö I. Ein aus Daten der Blutzirkulation kalkulierter Index zur Beurteilung der vegetativen Tonuslage. Acta Neurovegetativa (Wien). 1966; 29(2): 250-268.
Korda MM, Gozhenko AI, Fihura OA, Popovych DV, Żukow X, Popovych IL. Relationships between plasma levels of main adaptogene hormones and EEG&HRV parameters at human with dysadaptation. Journal of Education, Health and Sport. 2021; 11(12): 492-512.
Practical psychodiagnostics. Techniques and tests [in Russian]. Samara. Bakhrakh; 1998: 59-64.
Popovych IL, Gozhenko AI, Bombushkar IS, Korda MM, Zukow W. Sexual dimorphism in relationships between of uricemia and some psycho-neuro-endocrine parameters. Journal of Education, Health and Sport. 2015; 5(5): 556-581.
Popovych IL, Gozhenko AI, Korda MM, Klishch IM, Popovych DV, Zukow W (editors). Mineral Waters, Metabolism, Neuro-Endocrine-Immune Complex. Odesa. Feniks; 2022: 252.
Popovych IL, Kozyavkina OV, Kozyavkina NV, Korolyshyn TA, Lukovych YuS, Barylyak LG. Correlation between Indices of the Heart Rate Variability and Parameters of Ongoing EEG in Patients Suffering from Chronic Renal Pathology. Neurophysiology. 2014; 46(2): 139-148.
Popovych IL, Lukovych YuS, Korolyshyn TA, Barylyak LG, Kovalska LB, Zukow W. Relationship between the parameters heart rate variability and background EEG activity in healthy men. Journal of Health Sciences. 2013; 3(4): 217-240.
Shannon CE. A mathematical theory of information. Bell Syst Tech J. 1948; 27: 379-423.
Shaffer F, Ginsberg JP. An Overview of Heart Rate Variability Metrics and Norms. Front Public Health. 2017; 5: 258.
Spielberger CD. Manual for the State-Trait Anxiety Inventory (Form Y) Consulting Psychologists Press; Palo Alto (CA): 1983.
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