Poly ADP-ribose polymerase (PARP) inhibitors - new therapeutic strategies in Acute Myeloid Leukemia: a literature review

Authors

  • Emilia Nowicka Student Scientific Society, Laboratory of Genetic Diagnostics, Medical University of Lublin, A. Racławickie 1, 20-059 Lublin https://orcid.org/0000-0002-2743-1551
  • Michał Obel Uniwersytet Medyczny w Lublinie https://orcid.org/0000-0003-1237-8732
  • Kinga Panuciak Student Scientific Society, Laboratory of Genetic Diagnostics, Medical University of Lublin, A. Racławickie 1, 20-059 Lublin https://orcid.org/0000-0001-9014-5171
  • Angelika Mastalerczyk Student Scientific Society, Laboratory of Genetic Diagnostics, Medical University of Lublin, A. Racławickie 1, 20-059 Lublin https://orcid.org/0000-0002-7576-2152
  • Kamila Czyżak Student Scientific Society, Laboratory of Genetic Diagnostics, Medical University of Lublin, A. Racławickie 1, 20-059 Lublin https://orcid.org/0000-0002-8866-5810
  • Jan Lejman Student Scientific Society, Laboratory of Genetic Diagnostics, Medical University of Lublin, A. Racławickie 1, 20-059 Lublin https://orcid.org/0000-0002-8065-2839
  • Karolina Makowska Student Scientific Society, Laboratory of Genetic Diagnostics, Medical University of Lublin, A. Racławickie 1, 20-059 Lublin https://orcid.org/0000-0001-5467-3137
  • Wiktor Wiśniewski EMC Clinic, Łowiecka Street 24, 50-220 Wrocław https://orcid.org/0000-0001-5845-8012

DOI:

https://doi.org/10.12775/JEHS.2023.13.02.014

Keywords

PARP  inhibitor, Drug targets, Combination therapies, Acute leukemia, Acute Myeloid Leukemia

Abstract

The use of poly (ADP-ribose) polymerase (PARP) inhibitors has recently increased as a result of demonstrating their superior efficacy compared to traditional chemotherapy in various cancer subtypes in many preclinical studies and clinical trials. A better understanding of the molecular mechanisms of PARP and their underlying foci that can be used as screening markers for potential new therapeutic options would aid rational treatment strategies and improve long-term patient outcomes. The available data on acute leukemia suggest potential windows for effective treatment of PARPi in disease subgroups. In this review, we summarize the current advances in the most common PARP-based adjuvant therapies and combination strategies for the treatment of acute leukemia and discuss the future prospects and challenges of therapy with PARP inhibitors. We also discuss reports describing an increased risk of cancer treatment in patients receiving PARP inhibitors for solid tumors.

The research material were publications, the search was carried out using a combination of keywords such as: "PARP inhibitor", "acute leukemia", "therapy", "PARP clinical trials". The first step was to find relevant publications from the last 15 years. The second step was to review the publications found.

Studies have shown that PARP inhibitors play an increasing role in the treatment of leukemia. In addition, focusing research efforts on identifying the most effective drug combinations and sequences could help to further shape the role of PARPi in the treatment of acute myeloid leukemia (AML).

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2022-12-23

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1.
NOWICKA, Emilia, OBEL, Michał, PANUCIAK, Kinga, MASTALERCZYK, Angelika, CZYŻAK, Kamila, LEJMAN, Jan, MAKOWSKA, Karolina and WIŚNIEWSKI, Wiktor. Poly ADP-ribose polymerase (PARP) inhibitors - new therapeutic strategies in Acute Myeloid Leukemia: a literature review. Journal of Education, Health and Sport. Online. 23 December 2022. Vol. 13, no. 2, pp. 104-109. [Accessed 24 November 2024]. DOI 10.12775/JEHS.2023.13.02.014.

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Vol. 13 No. 2 (2023)

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Copyright (c) 2022 Emilia Nowicka, Michał Obel, Kinga Panuciak, Angelika Mastalerczyk, Kamila Czyżak, Jan Lejman, Karolina Makowska, Wiktor Wiśniewski

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