Urinary tract infection in children - short versus standard duration antibiotic therapy
DOI:
https://doi.org/10.12775/JEHS.2023.13.02.013Keywords
urinarytractinfection, pediatrics, pediatricnephrologyAbstract
Background: Urinary Tract Infection (UTI) is a common infection in children. Prompt diagnosis and appropriate treatment are very important to reduce the morbidity. Pediatric urologists are now faced with a situation that requires appropriate action- antibiotic resistance of urinary tract pathogens is significantly increasing worldwide.
Objective: The purpose of our work is to present the clinical aspects of antibiotic use in pediatric urology. To present the benefits of both short antibiotic therapy and standard antibiotic therapy.
Methods and materials: A literature review was conducted in the PubMed database, using the key words: "urinary tract infection", "children", "short-term antibiotics", "antibiotics", „nephrology”.
Results: Short-term antibiotic therapy for lower urinary tract infections appears to be as effective as standard therapy. Studies show that shorter antibiotic therapy also works well for pyelonephritis in pediatric patients. Children who have received a short course of antibiotic therapy may also be less likely to get subsequent infections in the future with a more resistant strain of the same uropathogen.
Conclusion: Tried to reconcile the latest reports on diagnosis, treatment and follow-up in pediatric UTIs with existing practice and opinions on the use of short as well as standard antibiotic therapy. However, more clinical trials are needed to confirm efficacy, and to assess side effects of the therapy
References
Kaufman J, Temple-Smith M, Sanci L. Urinary tract infections in children: an overview of diagnosis and management. BMJ Paediatr Open. 2019 Sep 24;3(1):e000487. doi: 10.1136/bmjpo-2019-000487. PMID: 31646191; PMCID: PMC6782125.
Schlager TA, Whittam TS, Hendley JO, Hollis RJ, Pfaller MA, Wilson RA, Stapleton A. Comparison of expression of virulence factors by Escherichia coli causing cystitis and E. coli colonizing the periurethra of healthy girls. J Infect Dis. 1995 Sep;172(3):772-7. doi: 10.1093/infdis/172.3.772. PMID: 7658071.
Robson W.L., Leung A.K., Boag G.S. Common pediatric urological disorders:
Clinical and radiological evaluation. Can. Fam. Physician. 1991;37:889–900.
Bochniewska V, Jung A, Żuber J. Zakażenie układu moczowego u dzieci. Editorial. 2012;8(1):12-22.
Zalecenia Polskiego Towarzystwa Nefrologii Dziecięcej (PTNFD) dot. postępowania z dzieckiem z zakażeniem układu moczowego, Forum Medycyny Rodzinnej 2016, tom 10, nr 4, str. 159–178
Leung AKC, Wong AHC, Leung AAM, Hon KL. Urinary Tract Infection in Children. Recent Pat Inflamm Allergy Drug Discov. 2019;13(1):2-18. doi: 10.2174/1872213X13666181228154940. PMID: 30592257; PMCID: PMC6751349.
Gondim R., Azevedo R., Braga A.A.N.M., Veiga M.L., Barroso U., Jr Risk factors for urinary tract infection in children with urinary urgency. Int. Braz J Urol. 2018;44(2):378–383
Okarska-Napierała M, Wasilewska A, Kuchar E. Urinary tract infection in children: Diagnosis, treatment, imaging – Comparison of current guidelines. J Pediatr Urol. 2017;13(6):567-573. doi:10.1016/j.jpurol.2017.07.018 9. Excellence NI for H and C, NICE. Urinary tract infection in under 16s : diagnosis and management. Nice. 2018;(August 2007):1-27. 10. White B. Diagnosis and treatment of urinary tract infections in children. Am Fam Physician. 2011 Feb 15;83(4):409-15. PMID: 21322515. 11. Finnell SM, Carroll AE, Downs SM; Subcommittee on Urinary Tract Infection. Technical report—Diagnosis and management of an initial UTI in febrile infants and young children. Pediatrics. 2011 Sep;128(3):e749-70. doi: 10.1542/peds.2011-1332. Epub 2011 Aug 28. PMID: 21873694.
Williams G, Craig JC. Long-term antibiotics for preventing recurrent urinary tract infection in children. Cochrane Database Syst Rev. 2019 Apr 1;4(4):CD001534. doi: 10.1002/14651858.CD001534.pub4. PMID: 30932167; PMCID: PMC6442022. 13. Buonsenso D, Sodero G, Mariani F, Lazzareschi I, Proli F, Zampino G, Pierantoni L, Valentini P, Rendeli C. Comparison between Short Therapy and Standard Therapy in Pediatric Patients Hospitalized with Urinary Tract Infection: A Single Center Retrospective Analysis. Children (Basel). 2022 Oct 28;9(11):1647. doi: 10.3390/children9111647. PMID: 36360375; PMCID: PMC9688884.
Kutasy B, Coyle D, Fossum M. Urinary Tract Infection in Children: Management in the Era of Antibiotic Resistance-A Pediatric Urologist's View. Eur Urol Focus. 2017 Apr;3(2-3):207-211. doi: 10.1016/j.euf.2017.09.013. Epub 2017 Sep 29. PMID: 28965960.
Vazouras K, Velali K, Tassiou I, Anastasiou-Katsiardani A, Athanasopoulou K, Barbouni A, Jackson C, Folgori L, Zaoutis T, Basmaci R, Hsia Y. Antibiotic treatment and antimicrobial resistance in children with urinary tract infections. J Glob Antimicrob Resist. 2020 Mar;20:4-10. doi: 10.1016/j.jgar.2019.06.016. Epub 2019 Jun 25. PMID: 31252156.
Michael M, Hodson EM, Craig JC, Martin S, Moyer VA. Short versus standard duration oral antibiotic therapy for acute urinary tract infection in children. Cochrane Database Syst Rev. 2003;(1):CD003966. doi: 10.1002/14651858.CD003966. PMID: 12535494.
Fox MT, Amoah J, Hsu AJ, Herzke CA, Gerber JS, Tamma PD. Comparative Effectiveness of Antibiotic Treatment Duration in Children With Pyelonephritis. JAMA Netw Open. 2020 May 1;3(5):e203951. doi: 10.1001/jamanetworkopen.2020.3951. PMID: 32364593; PMCID: PMC7199115.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Natalia Namroży, Robert Dubel, Aleksandra Czekaj, Kinga Ruszel, Julia Dubel, Konrad Merkisz, Sylwia Nemeczek, Jakub Grzybowski, Karolina Jaskuła, Władysław Orłowski
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 418
Number of citations: 0