Fibromyalgia in the light of different methods of treatment
DOI:
https://doi.org/10.12775/JEHS.2022.12.12.050Keywords
fibromyalgia, physiotheraphy, cannabis, cytokinesAbstract
Introduction and purpose: Fibromyalgia is a disease with many symptoms that are difficult to treat. The most troublesome element is muscle, bone or joint pain. Importantly, the diagnosis of this disease is based on the physical examination and the subjective examination, which shows that there are no laboratory tests to confirm its presence. Public awareness of fibromyalgia is negligible, while more research is needed on the treatment of this disease and the possible alternatives associated with it. The aim of this study was to analyze the available literature on the basis of the PubMed scientific database, considering only scientific articles that were published within the last 5 years. The following keywords were used: fibromyalgia and physiotherapy, fibromyalgia and cannabis, fibromyalgia and cytokines.
Description of the state of knowledge: Treatments related to cannabinoids and physiotherapy are still developing fields of knowledge. More than 40 papers related to the topic of the study were used for the review. The need for further research is apparent, especially randomized studies in which allocation to an experimental or control group is completely random. The question of investigating the long-term effectiveness of a given treatment is also not negligible, as many studies do not have a so-called follow-up.
Conclusion: Cannabinoids are effective in the treatment of complaints associated with fibromyalgia. Exercise, laser therapy and acupuncture reduce pain and improve quality of life in patients with fibromyalgia. More research on this disease is needed, especially with larger patient groups.
References
Bair, M. J., & Krebs, E. E. Fibromyalgia. Annals of internal medicine, 2020;172(5), ITC33–ITC48. https://doi.org/10.7326/AITC202003030
Pagliai, G., Giangrandi, I., Dinu, M., Sofi, F., & Colombini, B. Nutritional Interventions in the Management of Fibromyalgia Syndrome. Nutrients, 2020;12(9), 2525. https://doi.org/10.3390/nu12092525
Häuser, W., Sarzi-Puttini, P., & Fitzcharles, M. A. Fibromyalgia syndrome: under-, over- and misdiagnosis. Clinical and experimental rheumatology, 37 Suppl 2019;116(1), 90–97.
Araújo, F. M., & DeSantana, J. M. Physical therapy modalities for treating fibromyalgia. F1000Research, 2019;29;8, F1000 Faculty Rev-2030. https://doi.org/10.12688/f1000research.17176.1
Chinn, S., Caldwell, W., & Gritsenko, K. Fibromyalgia Pathogenesis and Treatment Options Update. Current pain and headache reports, 2016;20(4), 25. https://doi.org/10.1007/s11916-016-0556-x
Maffei M. E.Fibromyalgia: Recent Advances in Diagnosis, Classification, Pharmacotherapy and Alternative Remedies. International journal of molecular sciences, 2020;21(21), 7877. https://doi.org/10.3390/ijms21217877
Siracusa, R., Paola, R. D., Cuzzocrea, S., & Impellizzeri, D. Fibromyalgia: Pathogenesis, Mechanisms, Diagnosis and Treatment Options Update. International journal of molecular sciences, 2021;22(8), 3891. https://doi.org/10.3390/ijms22083891
Wolfe F., Smythe H.A., Yunus M.B., Bennett R.M., Bombardier C., Goldenberg D.L., Tugwell P., Campbell S.M., Abeles M., Clark P., et al. The american-college-of-rheumatology 1990 criteria for the classification of fibromyalgia—Report of the multicenter criteria committee. Arthritis Rheum. 1990;33:160–172. doi: 10.1002/art.1780330203.
Skorupska E., Samborski W. Diagnostyka różnicowa fibromialgii i zespołu bólu mięśniowo-powięziowego – rola oceny punktów tkliwych i punktów spustowych.. Forum Reumatologiczne. 2019;5. 60-64. 10.5603/FR.2019.0008.
Treede, R. D., Rief, W., Barke, A., Aziz, Q., Bennett, M. I., Benoliel, R., Cohen, M., Evers, S., Finnerup, N. B., First, M. B., Giamberardino, M. A., Kaasa, S., Korwisi, B., Kosek, E., Lavand'homme, P., Nicholas, M., Perrot, S., Scholz, J., Schug, S., Smith, B. H.,Wang, S. J. Chronic pain as a symptom or a disease: the IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11). Pain, 2019;160(1), 19–27. https://doi.org/10.1097/j.pain.0000000000001384
Cristino, L., Bisogno, T.,Di Marzo, V. Cannabinoids and the expanded endocannabinoid system in neurological disorders. Nature reviews. Neurology, 2020;16(1), 9–29 https://doi.org/10.1038/s41582-019-0284-z
Lu, H. C., & Mackie, K. Review of the Endocannabinoid System. Biological psychiatry. Cognitive neuroscience and neuroimaging, 2021;6(6), 607–615. https://doi.org/10.1016/j.bpsc.2020.07.016
Tzadok, R., & Ablin, J. N. Current and Emerging Pharmacotherapy for Fibromyalgia. Pain research & management, 2020, 6541798. https://doi.org/10.1155/2020/6541798
Amin, M. R., & Ali, D. W. Pharmacology of Medical Cannabis. Advances in experimental medicine and biology, 2019;1162, 151–165. https://doi.org/10.1007/978-3-030-21737-2_8
Jain, N., & Moorthy, A. Cannabinoids in rheumatology: Friend, foe or a bystander?. Musculoskeletal care, 2022;20(2), 416–428. https://doi.org/10.1002/msc.1636
Tham, M., Yilmaz, O., Alaverdashvili, M., Kelly, M., Denovan-Wright, E. M., & Laprairie, R. B. Allosteric and orthosteric pharmacology of cannabidiol and cannabidiol-dimethylheptyl at the type 1 and type 2 cannabinoid receptors. British journal of pharmacology, 2019;176(10), 1455–1469. https://doi.org/10.1111/bph.14440
Bourke, S. L., Schlag, A. K., O'Sullivan, S. E., Nutt, D. J., & Finn, D. P. Cannabinoids and the endocannabinoid system in fibromyalgia: A review of preclinical and clinical research. Pharmacology & therapeutics, 2022;240, 108216. Advance online publication. https://doi.org/10.1016/j.pharmthera.2022.108216
Boehnke, K. F., Gagnier, J. J., Matallana, L., & Williams, D. A. Cannabidiol Use for Fibromyalgia: Prevalence of Use and Perceptions of Effectiveness in a Large Online Survey. The journal of pain, 2021;22(5), 556–566. https://doi.org/10.1016/j.jpain.2020.12.001
Khurshid, H., Qureshi, I. A., Jahan, N., Went, T. R., Sultan, W., Sapkota, A., & Alfonso, M. A Systematic Review of Fibromyalgia and Recent Advancements in Treatment: Is Medicinal Cannabis a New Hope?. Cureus, 2021;13(8), e17332. https://doi.org/10.7759/cureus.17332
van de Donk, T., Niesters, M., Kowal, M. A., Olofsen, E., Dahan, A., & van Velzen, M. An experimental randomized study on the analgesic effects of pharmaceutical-grade cannabis in chronic pain patients with fibromyalgia. Pain, 2019;160(4), 860–869. https://doi.org/10.1097/j.pain.0000000000001464
Chaves, C., Bittencourt, P., & Pelegrini, A. Ingestion of a THC-Rich Cannabis Oil in People with Fibromyalgia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Pain medicine (Malden, Mass.), 2020;21(10), 2212–2218. https://doi.org/10.1093/pm/pnaa303
Bennett, R. M., Friend, R., Jones, K. D., Ward, R., Han, B. K., & Ross, R. L. (). The Revised Fibromyalgia Impact Questionnaire (FIQR): validation and psychometric properties. Arthritis research & therapy, 2009;11(4), R120. https://doi.org/10.1186/ar2783
Mazza M. (2021). Medical cannabis for the treatment of fibromyalgia syndrome: a retrospective, open-label case series. Journal of cannabis research, 3(1), 4. https://doi.org/10.1186/s42238-021-00060-6
Sagy I, Bar-Lev Schleider L, Abu-Shakra M, Novack V. Safety and Efficacy of Medical Cannabis in Fibromyalgia. J Clin Med. 2019 Jun 5;8(6):807. doi: 10.3390/jcm8060807. PMID: 31195754; PMCID: PMC6616435.
Zhang, X. C., Chen, H., Xu, W. T., Song, Y. Y., Gu, Y. H., & Ni, G. X. Acupuncture therapy for fibromyalgia: a systematic review and meta-analysis of randomized controlled trials. Journal of pain research, 2019;12, 527–542. https://doi.org/10.2147/JPR.S186227
Karatay, S., Okur, S. C., Uzkeser, H., Yildirim, K., & Akcay, F.. Effects of Acupuncture Treatment on Fibromyalgia Symptoms, Serotonin, and Substance P Levels: A Randomized Sham and Placebo-Controlled Clinical Trial. Pain medicine (Malden, Mass.), 2018;19(3), 615–628.
Kim J., Kim S.R., Lee H., Nam D.H. Comparing Verum and Sham Acupuncture in Fibromyalgia Syndrome: A Systematic Review and Meta-Analysis. Evid.-Based Complement. Alternat. Med. 2019
Deare J.C., Zheng Z., Xue C.C.L., Liu J.P., Shang J.S., Scott S.W., Littlejohn G. Acupuncture for treating fibromyalgia. Cochrane Database Syst. Rev. 2013 doi: 10.1002/14651858.CD007070.pub2.
Cao H.J., Li X., Han M., Liu J.P. Acupoint stimulation for fibromyalgia: A systematic review of randomized controlled trials. Evid. Based Complementary Altern. Med. 2013;2013:1–15. doi: 10.1155/2013/362831.
Izquierdo-Alventosa, R., Inglés, M., Cortés-Amador, S., Gimeno-Mallench, L., Chirivella-Garrido, J., Kropotov, J., & Serra-Añó, P. Low-Intensity Physical Exercise Improves Pain Catastrophizing and Other Psychological and Physical Aspects in Women with Fibromyalgia: A Randomized Controlled Trial. International journal of environmental research and public health, 2020;17(10), 3634. https://doi.org/10.3390/ijerph17103634
Sosa-Reina, M. D., Nunez-Nagy, S., Gallego-Izquierdo, T., Pecos-Martín, D., Monserrat, J., & Álvarez-Mon, M. (2017). Effectiveness of Therapeutic Exercise in Fibromyalgia Syndrome: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. BioMed research international, 2017, 2356346. https://doi.org/10.1155/2017/2356346
Gavi M. B., Vassalo D. V., Amaral F. T., et al. Strengthening exercises improve symptoms and quality of life but do not change autonomic modulation in fibromyalgia: a randomized clinical trial. PLoS ONE. 2014;9(3) doi: 10.1371/journal.pone.0090767.e90767
Larsson A., Palstam A., Löfgren M., et al. Resistance exercise improves muscle strength, health status and pain intensity in fibromyalgia-a randomized controlled trial. Arthritis Research and Therapy. 2015;17(1, article no. 161) doi: 10.1186/s13075-015-0679-1.
Vayvay, E. S., Tok, D., Turgut, E., & Tunay, V. B. The effect of Laser and taping on pain, functional status and quality of life in patients with fibromyalgia syndrome: A placebo- randomized controlled clinical trial. Journal of back and musculoskeletal rehabilitation, 2016;29(1), 77–83.
de Souza, R. C., de Sousa, E. T., Scudine, K. G., Meira, U. M., de Oliveira E Silva, E. M., Gomes, A. C., & Limeira-Junior, F. A. Low-level laser therapy and anesthetic infiltration for orofacial pain in patients with fibromyalgia: a randomized clinical trial. Medicina oral, patologia oral y cirugia bucal, 2018;23(1), e65–e71. https://doi.org/10.4317/medoral.21965
Germano Maciel, D., Trajano da Silva, M., Rodrigues, J. A., Viana Neto, J. B., de França, I. M., Melo, A. B. M., Barros da Silva, T. Y. P., & de Brito Vieira, W. H. Low-level laser therapy combined to functional exercise on treatment of fibromyalgia: a double-blind randomized clinical trial. Lasers in medical science, 2018;33(9), 1949–1959. https://doi.org/10.1007/s10103-018-2561-2
Qureshi, A. G., Jha, S. K., Iskander, J., Avanthika, C., Jhaveri, S., Patel, V. H., Rasagna Potini, B., & Talha Azam, A.. Diagnostic Challenges and Management of Fibromyalgia. Cureus, 2021;13(10), e18692. https://doi.org/10.7759/cureus.18692
Mücke, M., Phillips, T., Radbruch, L., Petzke, F., & Häuser, W.. Cannabis-based medicines for chronic neuropathic pain in adults. The Cochrane database of systematic reviews, 2018;3(3), CD012182. https://doi.org/10.1002/14651858.CD012182.pub2
Armagan O, Tascioglu F, Ekim A, Oner C. Long-term efficacy of low level laser therapy in women with fibromyalgia: A placebo-controlled study. J Back Musculoskelet Rehabil. 2006;19(4):135–140. doi: 10.3233/BMR-2006-19405.
Yeh, S. W., Hong, C. H., Shih, M. C., Tam, K. W., Huang, Y. H., & Kuan, Y. C. . Low-Level Laser Therapy for Fibromyalgia: A Systematic Review and Meta-Analysis. Pain physician, 2019;22(3), 241–254.
de Moraes Maia, M. L., Ribeiro, M. A., Maia, L. G., Stuginski-Barbosa, J., Costa, Y. M., Porporatti, A. L., Conti, P. C., & Bonjardim, L. R.. Evaluation of low-level laser therapy effectiveness on the pain and masticatory performance of patients with myofascial pain. Lasers in medical science, 2014;29(1), 29–35. https://doi.org/10.1007/s10103-012-1228-7
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