Current state of knowledge concerning experimental applications for deep brain stimulation in specific neurologic and psychiatric disorders
DOI:
https://doi.org/10.12775/JEHS.2022.12.12.042Keywords
Deep Brain Stimulation, Tourette syndrome, Alzheimer’s Disease, Depression, Huntington’s diseaseAbstract
Introduction and objectives. Deep brain stimulation (DBS) is an invasive treatment method of certain neurologic and psychiatric disorders. It relies on sending external electrical stimulus to specific targets within the brain, causing change in their functioning. DBS is an approved management procedure, for instance in Parkinson’s Disease or Obsessive-compulsive disorder. Currently, studies are being conducted on the possible utilization of DBS in other disorders, especially exhibiting resistance for standard treatment. The objective of this study, is to present the state of knowledge concerning experimental usage of DBS in specific disorders. The following study is based on the review of scientific literature for the years 2000 – 2022.
State of knowledge. Regarding experimental applications, DBS is being used among others in Tourette’s Syndrome, Huntington’s Disease, Depression and Alzheimer’s Disease. The review of the literature allows to gather data concerning initial patients selection, mechanism of action, potential benefits and thus far noted adverse effects. Evaluation of therapy efficacy is mostly limited, due to short observation periods and lack of unified patient qualification criteria for the operation.
Conclusion. Deep brain stimulation is a management method, in many cases acknowledged as safe and efficient. It is observed to have a beneficial impact on the disorders described in the following article. However, the approval of DBS as a conventional treatment requires improvement of many factors decisive of therapeutic success. Conduction of more randomised clinical trials in the future, may be helpful in achieving this objective.
References
Fritsch, G., Uber die elektrische Erregbarkeit des Grosshirns. Arch, anat. Physiol. Wiss. Med., 1870. 37: p. 300-332.
Gildenberg, P.L., Evolution of Neuromodulation. Stereotactic and Functional Neurosurgery, 2005. 83(2-3): p. 71-79.
Kringelbach, M.L., et al., Translational principles of deep brain stimulation. Nature Reviews Neuroscience, 2007. 8(8): p. 623-635.
Okun, M.S., Deep-brain stimulation for Parkinson's disease. N Engl J Med, 2012. 367(16): p. 1529-38.
Amon, A. and F. Alesch, Systems for deep brain stimulation: review of technical features. Journal of Neural Transmission, 2017. 124(9): p. 1083-1091.
Miocinovic, S., et al., History, Applications, and Mechanisms of Deep Brain Stimulation. JAMA Neurology, 2013. 70(2): p. 163-171.
Brice, J. and L. McLellan, SUPPRESSION OF INTENTION TREMOR BY CONTINGENT DEEP-BRAIN STIMULATION. The Lancet, 1980. 315(8180): p. 1221-1222.
Owen, S.L.F., et al., Deep brain stimulation for the alleviation of post-stroke neuropathic pain. Pain, 2006. 120(1): p. 202-206.
Koller, W.C., et al., Efficacy of unilateral deep brain stimulation of the vim nucleus of the thalamus for essential head tremor. 1999. 14(5): p. 847-850.
Vidailhet, M., et al., Bilateral Deep-Brain Stimulation of the Globus Pallidus in Primary Generalized Dystonia. 2005. 352(5): p. 459-467.
Lozano, Andres M. and N. Lipsman, Probing and Regulating Dysfunctional Circuits Using Deep Brain Stimulation. Neuron, 2013. 77(3): p. 406-424.
Chen, Y.-s., K. Shu, and H.-c. Kang, Deep Brain Stimulation in Alzheimer’s Disease: Targeting the Nucleus Basalis of Meynert. Journal of Alzheimer's Disease, 2021. 80: p. 53-70.
La Torre, D., et al., Deep brain stimulation for treatment-resistant depression: a safe and effective option. Expert Review of Neurotherapeutics, 2020. 20(5): p. 449-457.
Kaczyńska, J., et al., Is deep brain stimulation effective in Huntington’s Disease? — a systematic literature review. 2022. 56(4): p. 299-307.
Sanger, T.D., Deep brain stimulation for cerebral palsy: where are we now? 2020. 62(1): p. 28-33.
Leckman, J.F., et al., Tourette Syndrome: The Self Under Siege. 2006. 21(8): p. 642-649.
Freeman, R.D., et al., An international perspective on Tourette syndrome: selected findings from 3500 individuals in 22 countries. Developmental Medicine & Child Neurology, 2000. 42(7): p. 436-447.
Efron, D. and R.C. Dale, Tics and Tourette syndrome. 2018. 54(10): p. 1148-1153.
Rizzo, R., et al., A Randomized Controlled Trial Comparing Behavioral, Educational, and Pharmacological Treatments in Youths With Chronic Tic Disorder or Tourette Syndrome. 2018. 9.
Jankovic, J., Treatment of tics associated with Tourette syndrome. Journal of Neural Transmission, 2020. 127(5): p. 843-850.
Huasen, B., et al., Cervical myelopathy secondary to Tourette's syndrome managed by urgent deep brain stimulation. 2014. 29(4): p. 452-453.
Lu, Y.-Y., et al., Tourette syndrome increases risk of bone fractures: a population-based cohort study. European Child & Adolescent Psychiatry, 2017. 26(5): p. 531-539.
Lim, S., et al., Self-induced, Bilateral Retinal Detachment in Tourette Syndrome. Archives of Ophthalmology, 2004. 122(6): p. 930-931.
Hallett, M., Tourette Syndrome: Update. Brain and Development, 2015. 37(7): p. 651-655.
Kim, W. and N. Pouratian, Deep brain stimulation for Tourette syndrome. Neurosurg Clin N Am, 2014. 25(1): p. 117-35.
Müller-Vahl, K.R., et al., European clinical guidelines for Tourette syndrome and other tic disorders. Part IV: deep brain stimulation. European Child & Adolescent Psychiatry, 2011. 20(4): p. 209-217.
Müller-Vahl, K.R., Surgical treatment of Tourette syndrome. Neuroscience & Biobehavioral Reviews, 2013. 37(6): p. 1178-1185.
Ackermans, L., et al., Double-blind clinical trial of thalamic stimulation in patients with Tourette syndrome. Brain, 2011. 134(3): p. 832-844.
Servello, D., et al., Deep brain stimulation in 18 patients with severe Gilles de la Tourette syndrome refractory to treatment: the surgery and stimulation. Journal of Neurology, Neurosurgery & Psychiatry, 2008. 79(2): p. 136.
Servello, D., et al., De novo and rescue DBS leads for refractory Tourette syndrome patients with severe comorbid OCD: a multiple case report. Journal of Neurology, 2009. 256(9): p. 1533-1539.
Burdick, A., et al., Lack of benefit of accumbens/capsular deep brain stimulation in a patient with both tics and obsessive–compulsive disorder. Neurocase, 2010. 16(4): p. 321-330.
Dueck, A., et al., Deep Brain Stimulation of Globus Pallidus Internus in a 16-Year-Old Boy with Severe Tourette Syndrome and Mental Retardation. Neuropediatrics, 2009. 40(05): p. 239-242.
Duits, A., et al., Unfavourable outcome of deep brain stimulation in a Tourette patient with severe comorbidity. European Child & Adolescent Psychiatry, 2012. 21(9): p. 529-531.
Kakusa, B., et al., Robust Clinical Benefit of Multi-Lead Deep Brain Stimulation for Treatment of Gilles de la Tourette Syndrome and its Comorbidities. Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation, 2019. 12(2): p. 412.
Idris, Z., et al., Intracerebral haematomas after deep brain stimulation surgery in a patient with Tourette syndrome and low factor XIIIA activity. Journal of Clinical Neuroscience, 2010. 17(10): p. 1343-1344.
Querfurth, H.W. and F.M. LaFerla, Alzheimer's Disease. 2010. 362(4): p. 329-344.
Scheltens, P., et al., Alzheimer's disease. Lancet (London, England), 2016. 388(10043): p. 505-517.
Kozubski W., L.P., Neurologia. Podrecznik dla studentów medycyny. Tom 2. Wydanie II rozszerzone i auktualnione. 2020, Warszawa: PZWL.
Samanta, M.K., et al., Alzheimer Disease and Its Management: A Review. 2006. 13(6): p. 516-526.
Standaert, D.G., Treatment of central nervous system degenerative disorders. Goodman & Gilman's the pharmacological basis of therapeutics, 2006: p. 527-545.
Small, G.W., et al., Diagnosis and Treatment of Alzheimer Disease and Related Disorders: Consensus Statement of the American Association for Geriatric Psychiatry, the Alzheimer's Association, and the American Geriatrics Society. JAMA, 1997. 278(16): p. 1363-1371.
Casey, D.A., D. Antimisiaris, and J. O'Brien, Drugs for Alzheimer's disease: are they effective? P t, 2010. 35(4): p. 208-11.
Murray, P.S., et al., Psychosis in Alzheimer’s Disease. Biological Psychiatry, 2014. 75(7): p. 542-552.
Burns, A., et al., Brief psychotherapy in Alzheimer's disease: Randomised controlled trial. British Journal of Psychiatry, 2005. 187(2): p. 143-147.
Shafqat, S., Alzheimer Disease Therapeutics: Perspectives from the Developing World. Journal of Alzheimer's Disease, 2008. 15: p. 285-287.
Wong, W., Economic burden of Alzheimer disease and managed care considerations. The American journal of managed care, 2020. 26(8 Suppl): p. S177-S183.
Sperling, R.A., et al., Amyloid Deposition Is Associated with Impaired Default Network Function in Older Persons without Dementia. Neuron, 2009. 63(2): p. 178-188.
Aldehri, M., et al., Deep brain stimulation for Alzheimer's Disease: An update. Surg Neurol Int, 2018. 9: p. 58.
Hamani, C., et al., Memory enhancement induced by hypothalamic/fornix deep brain stimulation. 2008. 63(1): p. 119-123.
Hendelman, W., Atlas of Functional Neuroanatomy. 2nd Edition ed. 2005, Boca Raton: CRC Press.
Candy, J.M., et al., Pathological changes in the nucleus of meynert in Alzheimer's and Parkinson's diseases. Journal of the Neurological Sciences, 1983. 59(2): p. 277-289.
Etienne, P., et al., Nucleus basalis neuronal loss, neuritic plaques and choline acetyltransferase activity in advanced Alzheimer's disease. Neuroscience, 1986. 19(4): p. 1279-1291.
Baldermann, J.C., et al., Neuroanatomical Characteristics Associated With Response to Deep Brain Stimulation of the Nucleus Basalis of Meynert for Alzheimer’s Disease. Neuromodulation: Technology at the Neural Interface, 2018. 21(2): p. 184-190.
Kuhn, J., et al., Deep brain stimulation of the nucleus basalis of Meynert in Alzheimer’s dementia. Molecular Psychiatry, 2015. 20(3): p. 353-360.
Laxton, A.W., et al., A phase I trial of deep brain stimulation of memory circuits in Alzheimer's disease. 2010. 68(4): p. 521-534.
Lozano, A.M., et al., A Phase II Study of Fornix Deep Brain Stimulation in Mild Alzheimer’s Disease. Journal of Alzheimer's Disease, 2016. 54: p. 777-787.
Gratwicke, J., et al., The nucleus basalis of Meynert: A new target for deep brain stimulation in dementia? Neuroscience & Biobehavioral Reviews, 2013. 37(10, Part 2): p. 2676-2688.
Jakobs, M., D.J. Lee, and A.M. Lozano, Modifying the progression of Alzheimer's and Parkinson's disease with deep brain stimulation. Neuropharmacology, 2020. 171: p. 107860.
Malhi, G.S. and J.J. Mann, Depression. Lancet, 2018. 392(10161): p. 2299-2312.
Pełka-Wysiecka, J. and J. Samochowiec, Depresja — czy faktycznie zróżnicowana farmakoterapia? Psychiatria, 2014. 11(3): p. 141-147.
Kałucka, S.J.G., Cechy depresji w wieku podeszłymetiologia, rozpoznawanie i leczenie.[Characteristics of depression in the elderly-etiology, diagnosis and treatment]. 2014. 8: p. 240-247.
Gautam, S., et al., Clinical practice guidelines for the management of depression. 2017. 59(Suppl 1): p. S34.
Holtzheimer, P.E. and H.S.J.T.i.n. Mayberg, Stuck in a rut: rethinking depression and its treatment. 2011. 34(1): p. 1-9.
Gaynes, B.N., et al., Defining treatment‐resistant depression. 2020. 37(2): p. 134-145.
Minichino, A., et al., ECT, rTMS, and deepTMS in pharmacoresistant drug-free patients with unipolar depression: a comparative review. 2012. 8: p. 55.
Kisely, S., et al., Deep brain stimulation for obsessive–compulsive disorder: a systematic review and meta-analysis. 2014. 44(16): p. 3533-3542.
Wu, H., et al., Deep-brain stimulation for anorexia nervosa. 2013. 80(3-4): p. S29. e1-S29. e10.
Holtzheimer, P.E., et al., Subcallosal cingulate deep brain stimulation for treatment-resistant depression: a multisite, randomised, sham-controlled trial. 2017. 4(11): p. 839-849.
Mayberg, H.S., et al., Deep brain stimulation for treatment-resistant depression. 2005. 45(5): p. 651-660.
Mayberg, H.S., et al., Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness. 1999. 156(5): p. 675-682.
Seminowicz, D.A., et al., Limbic–frontal circuitry in major depression: a path modeling metanalysis. 2004. 22(1): p. 409-418.
Lozano, A.M., et al., Subcallosal cingulate gyrus deep brain stimulation for treatment-resistant depression. 2008. 64(6): p. 461-467.
Berlim, M.T., et al., Effectiveness and acceptability of deep brain stimulation (DBS) of the subgenual cingulate cortex for treatment-resistant depression: a systematic review and exploratory meta-analysis. 2014. 159: p. 31-38.
Kennedy, S.H., et al., Deep brain stimulation for treatment-resistant depression: follow-up after 3 to 6 years. 2011. 168(5): p. 502-510.
Dougherty, D.D., Deep Brain Stimulation: Clinical Applications. Psychiatr Clin North Am, 2018. 41(3): p. 385-394.
Rasmussen, S., et al., Neurosurgical approaches to intractable obsessive-compulsive disorder. 2000. 5(11): p. 23-34.
Malone Jr, D.A., et al., Deep brain stimulation of the ventral capsule/ventral striatum for treatment-resistant depression. 2009. 65(4): p. 267-275.
Dougherty, D.D., et al., A randomized sham-controlled trial of deep brain stimulation of the ventral capsule/ventral striatum for chronic treatment-resistant depression. 2015. 78(4): p. 240-248.
Bergfeld, I.O., et al., Deep brain stimulation of the ventral anterior limb of the internal capsule for treatment-resistant depression: a randomized clinical trial. 2016. 73(5): p. 456-464.
Walker, F.O., Huntington's Disease. Semin Neurol, 2007. 27(2): p. 143-50.
Paulsen, J.S. and J.D. Long, Onset of Huntington's disease: Can it be purely cognitive? 2014. 29(11): p. 1342-1350.
Adam, O.R. and J. Jankovic, Symptomatic Treatment of Huntington Disease. Neurotherapeutics, 2008. 5(2): p. 181-197.
Cubo, E., et al., Internal globus pallidotomy in dystonia secondary to Huntington's disease. 2000. 15(6): p. 1248-1251.
Gonzalez, V., et al., Deep brain stimulation for Huntington's disease: long-term results of a prospective open-label study: Clinical article. Journal of Neurosurgery JNS, 2014. 121(1): p. 114-122.
Kaczyńska, J., et al., Is deep brain stimulation effective in Huntington’s Disease? — a systematic literature review. Neurologia i Neurochirurgia Polska, 2022. 56(4): p. 299-307.
Moro, E., et al., Bilateral globus pallidus stimulation for Huntington's disease. 2004. 56(2): p. 290-294.
Sharma, M. and M. Deogaonkar, Deep brain stimulation in Huntington’s disease: Assessment of potential targets. Journal of Clinical Neuroscience, 2015. 22(5): p. 812-817.
Banaszkiewicz, K., et al., Huntington’s disease from the patient, caregiver and physician’s perspectives: three sides of the same coin? Journal of Neural Transmission, 2012. 119(11): p. 1361-1365.
Zittel, S., et al., Prospective evaluation of Globus pallidus internus deep brain stimulation in Huntington's disease. Parkinsonism & Related Disorders, 2018. 51: p. 96-100.
Wojtecki, L., et al., A prospective pilot trial for pallidal deep brain stimulation in Huntington´s disease. 2015. 6.
Sanrey, E., et al., Does pallidal neuromodulation influence cognitive decline in Huntington’s disease? Journal of Neurology, 2021. 268(2): p. 613-622.
Turnbull, I.M., et al., Stimulation of the Basal Nucleus of Meynert in Senile Dementia of Alzheimer’s Type. Stereotactic and Functional Neurosurgery, 1985. 48(1-6): p. 216-221.
Hariz, M.I., Complications of deep brain stimulation surgery. 2002. 17(S3): p. S162-S166.
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