Diagnostic value of matrix metalloproteinase-9 in the course of osteoarthritis in young persons with excessive body weight and obesity
DOI:
https://doi.org/10.12775/JEHS.2022.12.06.039Keywords
osteoarthritis, obesity, matrix metalloproteinase-9Abstract
In 125 patients with osteoarthritis (OA), among whom 75 had increased body weight, the content of matrix metalloproteinase-9 (MMP-9) was studied. It was established that the course of OA is accompanied by an increase in the content of MMP-9, which correlates with the body mass index. It was proved that the activity of this enzyme did not depend on gender and age in young patients, but had a direct correlative dependence on the radiological stage of the disease.
It is recommended to use this enzyme as an additional criterion for the course of osteoarthritis and control of treatment measures.
References
Pasiyeshvili, L. M., Istomin, A. G., Tereshkin, K. I., & Tereshkina, O. I. (2020). Polymorphism of the vitamin D receptor gene as a factor in the early formation of osteopenic conditions in the case of the combined course of osteoarthritis and obesity in young people.
Monastery B.J. Diseases of the musculoskeletal system. Trans. with English M.: Iz-vo Panfilov, 2020. - 1152 p.
Sinyachenko O.V. Diagnosis and treatment of joint diseases. Iz-l Zaslavsky A.Yu. ELVI-SPb, 2012.-560.
Okada , A ., & Okada , Y . (2009). Clinical calcium , 19 (11), 1593–1601.
Jahanban ‐ Esfahlan, R ., Mehrzadi, S ., Reiter, R . J ., Seidi, K ., Majidinia, M ., Baghi, H . B. , ... & Sadeghpour, A. (2018). Melatonin in regulation of inflammatory pathways in rheumatoid arthritis and osteoarthritis: involvement of circadian clock genes. British journal of pharmacology , 175 (16), 3230-3238 .
H. Deshmukh , C. Barroga , L. Dellamary , Y. Yazici , A small-molecule inhibitor of the Wnt pathway (SMO4690) as a potential disease modifying agent for the treatment of osteoarthritis of the knee, Osteoarth . Cartil . 26 (1) (2017) 18–27 .
N. G. Li , Z._ H. Shi , Y. P. Tang , J. A. Duan , New hope for the treatment of osteoarthritis through selective inhibition of MMP -13, Curr . Med . Chem . 18 (7) (2011) 977–1001.
M. C. Chun , M. D. Christopher , J. L. Gary , D. R. Andrew , Cytokin - induced MMP 13 expression in human chondrocytes is dependent he activating transcription factor 3 ( ATF 3 ) regulation , J. Biol . Chem . 292 (5) (2016) 1625–1636.
Van day Steen Ph . Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9) / Ph. Van den Steen // Critical. Reviews in Biochem . and Molec . Biology. - 2002. - Vol. 37. – No. 6. – P. 375–536 .
Mehana, E. E. , Khafaga, A. F. , & El - Blehi, S. S. (2019). The role of matrix metalloproteinases in osteoarthritis pathogenesis: An updated review. Life sciences , 234 , 116786. https://doi.org/10.1016/j.lfs.2019.116786 .
MMP - 9 microsatellite polymorphism and susceptibility that carotid arteries atherosclerosis / N. Fiotti , N. Altamura, M. Fisicaro et al. // Arterioscler Thromb Vasc Biol. - 2006. - Vol. 26. – P. 1330–1336. Visse R. Matrix metalloproteinases and tissue inhibitors of metalloproteinases : structure, function, and biochemistry / R. Visse , H. Nagase // Circulation Res. – 2003. – No. 2. – P. 827–839 .
Glyn-Jones, S., Palmer, AJ, Agricola, R., Price, AJ, Vincent, TL, Weinans , H., & Carr, AJ (2015). Osteoarthritis. Lancet (London, England), 386 (9991), 376–387. https://doi.org/10.1016/S0140-6736(14)60802-3 ) .
Li H , Li L , Min J , Yang H , Xu X , Yuan Y , et al . Levels of metalloproteinase (MMP-3, MMP-9), NF- kappaB ligand (RANKL), and nitric oxide (NO) in peripheral blood of osteoarthritis (OA) patients. Clin Lab. 2012;58(7-8):755–62.
Luo, S., Li, W., Wu, W., & Shi, Q. (2021). Elevated expression of MMP8 and MMP9 contributes to diabetic osteoarthritis progression in a rat model. Journal of Orthopedic Surgery and Research , 16 (1), 1-9.
Camp TM, Tyagi SC, Senior RM, Hayden MR, Tyagi SC. Gelatinase B(MMP-9) an apoptotic factor in diabetic transgenic mice. Diabetology . 2013;46(10):1438– 45 .
Slovacek , H., Khanna, R., Poredos , P., Jezovnik , M., Hoppensteadt , D., Fareed, J., & Hopkinson, W. (2020). Interrelationship of osteopontin , MMP-9 and ADAMTS4 in patients with osteoarthritis undergoing total joint arthroplasty. Clinical and applied thrombosis/hemostasis, 26, 1076029620964864.
Jarecki, J ., Małecka - Masalska, T ., Kosior - Jarecka, E ., Widuchowski, W ., Krasowski, P ., Gutbier, M., ... & Blicharski, T. (2022). Concentration of Selected Metalloproteinases and Osteocalcin in the Serum and Synovial Fluid of Obese Women with Advanced Knee Osteoarthritis. International Journal of Environmental Research and Public Health , 19 (6), 3530.
Jabłońska-Trypuć A, Matejczyk M, Rosochacki S. Matrix metalloproteinases (MMPs), the main extracellular matrix (ECM) enzymes in collagen degradation, as a target for anticancer drugs. J Enzyme Inhib Med Chem. 2016;31(sup1):177–83. (17).
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 A. Litvynova, L. Pasieshvili, A. Zagrebelska, T. Hadirova
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 262
Number of citations: 0
