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Journal of Education, Health and Sport

What we know about oral collagen supplementation for skin health - a literature review
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What we know about oral collagen supplementation for skin health - a literature review

Authors

  • Aleksandra Słupczyńska Samodzielny Publiczny Szpital Kliniczny nr 1 w Lublinie, ul. Stanisława Staszica 16, 20-400 Lublin https://orcid.org/0000-0003-3615-002X
  • Kamila Gorczyca Department of Obstetrics and Perinatology, Medical University of Lublin https://orcid.org/0000-0002-7976-0509
  • Klaudia Artykiewicz Samodzielny Publiczny Szpital Kliniczny nr 4 w Lublinie https://orcid.org/0000-0003-2912-4691
  • Weronika Urbaś Medical University of Lublin https://orcid.org/0000-0002-5260-2172
  • Klaudia Podgórska Samodzielny Publiczny Szpital Kliniczny nr 4 w Lublinie https://orcid.org/0000-0002-5109-900X
  • Aleksandra Puła Wojewódzki Szpital Specjalistyczny im. Kardynała Stefana Wyszyńskiego SPZOZ w Lublinie https://orcid.org/0000-0001-9001-5051
  • Marcin Czarkowski Medical University of Lublin https://orcid.org/0000-0001-5663-2574
  • Paweł Kozieł Medical University of Lublin https://orcid.org/0000-0001-6069-6028
  • Maria Grodkiewicz Medical University of Lublin https://orcid.org/0000-0002-6243-9102
  • Urszula Krzysiek Szpital Solec Spółka z Ograniczoną Odpowiedzialnością w Warszawie https://orcid.org/0000-0002-4712-2334

DOI:

https://doi.org/10.12775/JEHS.2023.13.01.038

Keywords

collagen, collagen peptides, antiaging, skin health, nutriceuticals

Abstract

ABSTRACT
Introduction: The efforts to restore lost collagen, regain youthful-looking skin and healthier joints have made collagen oral supplements a huge trend of the last few years. Because collagen is the main building protein of our body, many people may ask themselves - can collagen supplementation have a real impact on our health? Are these nutraceuticals a fountain of youth in a bottle or nothing more than marketing hype?
The aim of the study: The aim of this paper was to present the current state of knowledge on the supplementation of collagen and application of collagen in oral nutraceuticals.
Material and methods: Literature review available on PubMed, Science Direct and Google Scholar and evaluation of available randomized controlled trials using collagen supplementation in terms of treatment effectiveness in terms of skin quality, anti-aging benefits and potential use in dermatology. Abstracts, comments, and non-English language articles were excluded.
Conclusions: Collagen is important for maintaining the structural integrity of every tissue in the body. Despite many studies on collagen supplementation, the literature is still impecunious, but the scientific works so far confirm that supplementation with hydrolyzed collagen can improve various aspects of skin aging.
Key words: collagen, collagen peptides, antiaging, skin health, nutraceuticals

References

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Mienaltowski, M. J., & Birk, D. E. (2014). Structure, physiology, and biochemistry of collagens. Progress in heritable soft connective tissue diseases, 5-29.

Baumann, L. (2007). Skin ageing and its treatment. The Journal of Pathology: A Journal of the Pathological Society of Great Britain and Ireland, 211(2), 241-251.

Czajka, A., Kania, E. M., Genovese, L., Corbo, A., Merone, G., Luci, C., & Sibilla, S. (2018). Daily oral supplementation with collagen peptides combined with vitamins and other bioactive compounds improves skin elasticity and has a beneficial effect on joint and general wellbeing. Nutrition Research, 57, 97-108.

König, D., Oesser, S., Scharla, S., Zdzieblik, D., & Gollhofer, A. (2018). Specific collagen peptides improve bone mineral density and bone markers in postmenopausal women—a randomized controlled study. Nutrients, 10(1), 97.

Sakai S, Yasuda R, Sayo T, Ishikawa O, Inoue S. Hyaluronan exists in the normal stratum corneum. J Invest Dermatol. 2000;114(6):1184–7.

Oba C, Ohara H, Morifuji M, Ito K, Ichikawa S, Kawahata K, Koga J. Collagen hydrolysate intake improves the loss of epidermal barrier function and skin elasticity induced by UVB irradiation in hairless mice. Photodermatol Photoimmunol Photomed. 2013;29(4):204–11.

Ohara H, Ichikawa S, Matsumoto H, Akiyama M, Fujimoto N, Kobayashi T, Tajima S. Collagen-derived dipeptide, proline-hydroxyproline, stimulates cell proliferation and hyaluronic acid synthesis in cultured human dermal fibroblasts. J Dermatol. 2010;37(4):330–8

Shimizu J, Asami N, Katatoka A, et al. Oral collagen-derived dipeptides, prolyl-hydroxyproline and hydroxyprolyl-glycine, ameliorate skin barrier dysfunction and alter gene expression profiles in the skin. Biochem Biophys Res Commun. 2015;456(2):626–30.

Tanaka M, Koyama V, Nomura Y. Effects of collagen peptide ingestion on UV-B–induced skin damage. Biosci Biotechnol Biochem. 2009;73(4):930–2

Liang J, Pei X, Zhang Z, Wang N, Wang J, Li Y. The protective effects of longterm oral administration of marine collagen hydrolysate from chum salmon on collagen matrix homeostasis in the chronological aged skin of Sprague– Dawley male rats. J Food Sci. 2010;75(8):H230–8

Shigemura Y, Iwai K, Morimatsu F, et al. Effect of Prolyl-hydroxyproline (Pro-Hyp), a food-derived collagen peptide in human blood, on growth of fibroblasts from mouse skin. J Agric Food Chem. 2009:57(2):444–9

Zague V, Freitas V, Costa Rosa M, Castro GA, Jaeger RG, Machado-Santelli GM: Collagen hydrolysate intake increases skin collagen expression and suppresses matrix metalloproteinase 2 activity. J Med Food 2011;14(6):618- 24.

Proksch, E., Segger, D., Degwert, J., Schunck, M., Zague, V., & Oesser, S. (2014). Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study. Skin pharmacology and physiology, 27(1), 47-55.

Liang J, Pei X, Zhang Z, Wang N, Wang J, Li Y: The protective effects of long-term oral administration of marine collagen hydrolysate from chum salmon on collagen matrix homeostasis in the chronological aged skin of Sprague-Dawley male rats. J Food Sci 2010;75 (8):H230-8.

Asserin J, Lati, E, Shioya B, Prawitt J. The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: Evidence from an ex vivo model and randomized, placebo-controlled clinical trials. J Cosmet Dermatol. 2015;14(4):291–301.

Albini A, Adelmann-Grill BC. Collagenolytic cleavage products of collagen type I as chemoattractants for human dermal fibroblasts. Eur J Cell Biol. 1985;36(1):104–7.

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Published

2022-12-05

How to Cite

1.
SŁUPCZYŃSKA, Aleksandra, GORCZYCA, Kamila, ARTYKIEWICZ, Klaudia, URBAŚ, Weronika, PODGÓRSKA, Klaudia, PUŁA, Aleksandra, CZARKOWSKI, Marcin, KOZIEŁ, Paweł, GRODKIEWICZ, Maria and KRZYSIEK, Urszula. What we know about oral collagen supplementation for skin health - a literature review. Journal of Education, Health and Sport. Online. 5 December 2022. Vol. 13, no. 1, pp. 259-262. [Accessed 28 June 2025]. DOI 10.12775/JEHS.2023.13.01.038.
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Issue

Vol. 13 No. 1 (2023)

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Short Articles

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Copyright (c) 2022 Aleksandra Słupczyńska, Kamila Gorczyca, Klaudia Artykiewicz, Weronika Urbaś, Klaudia Podgórska, Aleksandra Puła, Marcin Czarkowski, Paweł Kozieł, Maria Grodkiewicz, Urszula Krzysiek

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

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