3D bioprinting as a future of regenerative medicine and hope for transplantology
DOI:
https://doi.org/10.12775/JEHS.2023.13.01.005Keywords
bioprinting 3d, Regenerative medicine, tissue biofabricationAbstract
Introduction: 3D bioprinting is a continuously refined technology that enables tissue structures to be faithfully reproduced, using specially developed bioinks and 3D printers. Thanks to its versatility, it is possible to use it in regenerative medicine and transplantation, which could have a positive impact on the survival and comfort of patients with injuries and those awaiting transplantation.
Aim of the study: Summarise the current state of knowledge on the use of 3D bioprinting technology in the field of regenerative medicine and transplantation, to present the extent of the method's capabilities and examples of its applications, and to outline what role it will play in the future of medicine.
Methods and materials: A review of the literature available in the PubMed database and Google Scholar from the last 5 years was conducted, using the following keywords: 3d bioprinting, regenerative medicine, tissue biofabrication.
Results: Significant progress has been made in the field of bioprinting and various types of tissue are now being printed and tested. Current research into the printing of skin tissue leads us to believe that in the coming years, 3D bioprinting using stem cells will make it possible to significantly improve the treatment of skin injuries. Researchers are also working on using this technology in the field of neurology and bone damage.
Conclusion: The dynamic development of 3D bioprinting technology offers the hope of eliminating the main transplantation problem related to donor availability. However, the road to wider clinical application of this technology is still a long one, due to the numerous technological difficulties associated with the development of bioprinters, advanced printers and a thorough understanding of human tissue architecture. With the current intensified research in this field, it is expected that these problems will be eliminated in time and the technology will gain more interest from clinicians.
References
Ishita Matai, Gurvinder Kaur, Amir Seyedsalehi, Aneesah McClinton, Cato T Laurencin. Progress in 3D bioprinting technology for tissue/organ regenerative engineering. Biomaterials. 2020 Jan;226:119536. doi: 10.1016/j.biomaterials.2019.119536. Epub 2019 Oct 11. PMID: 31648135.
Marcel Alexander Heinrich, Wanjun Liu, Andrea Jimenez, Jingzhou Yang, Ali Akpek, Xiao Li Qingmeng Pi, Xuan Mu, Ning Hu, Raymond Michel Schiffelers, Jai Prakash, Jingwei Xie, and Yu Shrike Zhang. 3D Bioprinting: from Benches to Translational Applications. Small. 2019 Jun;15(23):e1805510. doi: 10.1002/smll.201805510. Epub 2019 Apr 29. PMID: 31033203. PMCID: PMC6752725.
Sean V. Murphy , Paolo De Coppi, Anthony Atala. Opportunities and challenges of translational 3D bioprinting. Nat Biomed Eng. 2020 Apr;4(4):370-380. doi: 10.1038/s41551-019-0471-7. Epub 2019 Nov 6. PMID: 31695178.
Nhayoung Hong, Gi-Hoon Yang, JaeHwan Lee, GeunHyung Kim. 3D bioprinting and its in vivo applications. J Biomed Mater Res B Appl Biomater. 2018 Jan;106(1):444-459. doi: 10.1002/jbm.b.33826. Epub 2017 Jan 20. PMID: 28106947.
Zengmin Xia, Sha Jin, Kaiming Ye. Tissue and Organ 3D Bioprinting. SLAS Technol. 2018 Aug;23(4):301-314. doi: 10.1177/2472630318760515. Epub 2018 Feb 23. PMID: 29474789.
Sam P. Tarassoli, Zita M. Jessop, Ayesha Al-Sabah, Neng Gao, Sairan Whitaker, Shareen Doak, Iain S. Whitaker. Skin tissue engineering using 3D bioprinting: An evolving research field. J Plast Reconstr Aesthet Surg. 2018 May;71(5):615-623. doi: 10.1016/j.bjps.2017.12.006. Epub 2017 Dec 13. PMID: 29306639.
Wei-Cheng Yan, Pooya Davoodi, S. Vijayavenkataraman, Yuan Tian, Wei Cheng Ng, Jerry Y.H. Fuh, Kim Samirah Robinson, Chi-Hwa Wang, 3D bioprinting of skin tissue: From pre-processing to final product evaluation. Adv Drug Deliv Rev. 2018 Jul;132:270-295. doi: 10.1016/j.addr.2018.07.016. Epub 2018 Jul 26. PMID: 30055210.
Luciana Y. Daikuara, Xifang Chen, Zhilian Yue, Danielle Skropeta, Fiona M. Wood, Mark W. Fear, Gordon G. Wallace. 3D Bioprinting Constructs to Facilitate Skin Regeneration. Adv. Funct. Mater. 2021, 19 August 2021, 2105080. doi: 10.1002/adfm.202105080.
Rui Wang, Yihui Wang, Bin Yao, Tian Hu, Zhao Li, Sha Huang, Xiaobing Fu. Beyond 2D: 3D bioprinting for skin regeneration. Int Wound J. 2019 Feb;16(1):134-138. doi: 10.1111/iwj.13003. Epub 2018 Sep 21. PMID: 30240111. PMCID: PMC7949282.
Peng He, Junning Zhao, Jiumeng Zhang, Bo Li 3, Zhiyuan Gou, Maling Gou, Xiaolu Li. Burns Trauma. Bioprinting of skin constructs for wound healing. 2018 Jan 23;6:5. doi: 10.1186/s41038-017-0104-x. eCollection 2018. PMID: 29404374. PMCID: PMC5778803.
Sanjairaj Vijayavenkataraman, Wei-Cheng Yan, Wen Feng Lu, Chi-Hwa Wang, Jerry Ying Hsi Fuh. 3D bioprinting of tissues and organs for regenerative medicine. Adv Drug Deliv Rev. 2018 Jul;132:296-332. doi: 10.1016/j.addr.2018.07.004. Epub 2018 Jul 7. PMID: 29990578.
Moyuan Qu, Canran Wang, Xingwu Zhou, Alberto Libanori, Xing Jiang, Weizhe Xu, Songsong Zhu, Qianming Chen, Wujin Sun, Ali Khademhosseini. Multi-Dimensional Printing for Bone Tissue Engineering. Adv Healthc Mater. 2021 Jun;10(11):e2001986. doi: 10.1002/adhm.202001986. Epub 2021 Apr 19. PMID: 33876580. PMCID: PMC8192454.
Tesfa Marew, Gebremariam Birhanu. Three dimensional printed nanostructure biomaterials for bone tissue engineering. Regen Ther. 2021 May 28;18:102-111. doi: 10.1016/j.reth.2021.05.001. eCollection 2021 Dec. PMID: 34141834. PMCID: PMC8178073.
Melissa Cadena, Liqun Ning, Alexia King, Boeun Hwang, Linqi Jin, Vahid Serpooshan, Steven A Sloan. 3D Bioprinting of Neural Tissues. Adv Healthc Mater. 2021 Aug;10(15):e2001600. doi: 10.1002/adhm.202001600. Epub 2020 Nov 16. PMID: 33200587. PMCID: PMC8711131.
Xiaoling Yu, Tian Zhang, Yuan Li. 3D Printing and Bioprinting Nerve Conduits for Neural Tissue Engineering. Polymers (Basel). 2020 Jul 23;12(8):1637. doi: 10.3390/polym12081637. PMID: 32717878. PMCID: PMC7465920.
Daeha Joung, Nicolas S Lavoie, Shuang-Zhuang Guo, Sung Hyun Park, Ann M Parr, Michael C McAlpine. 3D Printed Neural Regeneration Devices. Adv Funct Mater. 2020 Jan 3;30(1):10.1002/adfm.201906237. doi: 10.1002/adfm.201906237. Epub 2019 Nov 8. PMID: 32038121. PMCID: PMC7007064.
Ashley N Leberfinger, Shantanab Dinda, Yang Wu, Srinivas V Koduru, Veli Ozbolat, Dino J Ravnic, Ibrahim T Ozbolat. Bioprinting functional tissues. Acta Biomater. 2019 Sep 1;95:32-49. doi: 10.1016/j.actbio.2019.01.009. Epub 2019 Jan 11. PMID: 30639351, PMCID: PMC6625952.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Konrad Gładysz, Justyna Szydłowska, Olga Żuchnik, Olgierd Król, Piotr Kwiatkowski, Beata Kuczyńska, Magdalena Czelej, Aleksander Kłos, Krzysztof Gieroba, Marcin Szydłowski
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 1025
Number of citations: 0
