Гепатопротекторные свойства полифенольных веществ экстракта «Дубовый» = Hepatoprotective properties of polyphenols substances of Oak extract

Abstract

Levitsky A. P., Makarenko O. A., Khodakov I. V., Lukanin A. S., Lukanina M. A. Гепатопротекторные свойства полифенольных веществ экстракта «Дубовый» = Hepatoprotective properties of polyphenols substances of Oak extract. Journal of Education, Health and Sport. 2016;6(11):537-547. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.192393

http://ojs.ukw.edu.pl/index.php/johs/article/view/4039

The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).

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© The Author (s) 2016;

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This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial

use, distribution and reproduction in any medium, provided the work is properly cited.

The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 02.11.2016. Revised 22.11.2016. Accepted: 30.11.2016.

УДК 615.07+615.015+616.98

ГЕПАТОПРОТЕКТОРНЫЕ СВОЙСТВА ПОЛИФЕНОЛЬНЫХ ВЕЩЕСТВ ЭКСТРАКТА «ДУБОВЫЙ»

А. П. Левицкий¹, О. А. Макаренко¹, И. В. Ходаков¹,

А. С. Луканин², М. А. Луканина³

¹ГУ «Институт стоматологии и челюстно-лицевой хирургии Национальной академии медицинских наук Украины» (г. Одесса) E-mail: flavan@mail.ru

²Лаборатория мониторинга сырьевых ресурсов для виноделия (г. Киев)

³ГП «Государственный центр сертификации и экспертизы

сельскохозяйственной продукции Минагрополитики Украины» (г. Киев)

Резюме

Экстракт «Дубовый» обладает гепатопротекторным действием при токсическом гепатите.

Ключевые слова: гепатит, полифенолы дуба, гепатопротектор, ферменты, липиды.

HEPATOPROTECTIVE PROPERTIES OF POLYPHENOLS

SUBSTANCES OF OAK EXTRACT

A. P. Levitsky, O. A. Makarenko, I. V. Khodakov, A. S. Lukanin, M. A. Lukanina

¹SE «The Institute of Stomatology and Maxillo-Facial Surgery of the NAMS of Ukraine» (Odessa, Ukraine) flavan@mail.ru

²The Laboratory of monitoring of raw materials for wine-making (Kiev, Ukraine)

³The state of sertification and expertise agriculture products of Ministry of
 agropolitics (Kiev, Ukraine)

Summary

Purpose of work: To determine of hepatoprotective properties of oak extract.

Materials and methods: The oak extract, wich contained 1,3 % polyphenols, was used. The hepatoprotective properties were determined using rats with hydrazine hepatitis. The oak extract was introduced in dose of 10 ml/kg from the first day of the experiment during 13 days. The liver state was estimated by inflammation indices (elastase, MDA) index of microbe sowing (urease), index of non-specific immunity (lysozyme), index of cholestasis (alkaline phosphotase, AlPh). The liver markers (bilirubine, ALT, AlPh) were determined into serum. The levels of triglycerides and total cholesterine were determined into liver and serum.

Results: The oak extract reduced of inflammation indices, the activaties of urease, AlPh into liver and the degree of dysbiosis into liver and serum.

The conclusion: The oak extract has hepatoprotective action.

Key words: hepatite, polyphenols of oak, hepatoprotectore, enzymes, lipids.