Dynamic of blood glucose levels in the model of experimental diabetic retinopathy and different ways to correct it
DOI:
https://doi.org/10.12775/JEHS.2021.11.07.036Keywords
experimental diabetic retinopathy, streptozotocin diabetes, blood glucose, correction, metformin, aflibercept, bromfenac, L-carnitine, L-arginine, citicolineAbstract
The aim of our study was to analyze the changes in the blood glucose level in experimental animals that simulated diabetic retinopathy and against the background of its correction. The obtained results show the development of experimental diabetes when streptozotocin is administered at a dose of 55 mg/kg of animal weight against the background of a high-fat diet. Correction with hypoglycemic agents in the 3rd group had a positive effect, but it was not able to completely normalize the level of glycemia, so the need arose for the use of additional agents. The use of aflibercept and a nitric oxide donor in the 4th group had a more pronounced positive effect compared to the 3rd group, but the result did not reach the control indicators. Combined administration of bromfenac and aflibercept in the 5th group showed itself to be less effective in the study of the blood glucose level at all stages in comparison with the data of the 4th group, in which the NO donor was involved in the correction. Administation of aflibercept, L-carnitine and bromfenac to the animals of the 6th group had a more pronounced positive effect in comparison with the group No. 5, but did not reach the values of the 4th group of the experiment. The most effective correction was the combination of metformin, aflibercept, L-arginine and citicoline in rats of the 7th group, which is evidenced by the normalization of the level of the studied indicators on the 30th and 60th days of the experiment, and on the 180th, the most pronounced decrease was recorded hyperglycemia.
References
Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, et al. Heart disease and stroke statistic – 2016 update. A report from the American Heart Association. Circulation. 2016;133(4):38-360.
Jendotelij. Fiziologija i patologija: monografija /A.S.Kuznecova, A.I. Gozhenko, E.S. Kuznecova, V.V.Shuhtin, E.N. Kuznecova, S.G. Kuznecov. – Odessa: «Feniks», 2018. – 284 s.
Abbate M, Cravedi P, Iliev I, et al. Prevention and treatment of diabetic retinopathy: evidence from clinical trials and perspectives // Curr Diabetes Rev. — 2011. — Vol. 7. — P. 190-200.
Mal'cev Je.V., Zborovskaja A.V., Dorohova A.Je. Fundamental'nye aspekty razvitija i lechenija diabeticheskoj retinopatii: monografija. Odessa: Astroprint, 2018. 220 s.:il.
Leus NF. Metabolicheskie mehanizmy razvitija i perspektivy medikamentoznogo lechenija diabeticheskoj retinopatii. Oftal'mol. zhurnal. 2003;5:75-80.
Zhi Zheng, Haibin Chen, Hong Wang, et al. Improvement of retinal vascular injury in diabetic rats by statins is associated with the inhibition of mitochondrial reactive oxygen species pathway mediated by peroxisome proliferator-activated receptor y coactivator 1 a. Diabetes. 2010;59:2315-2325.
Mamta Kanwar, Kowluru RA. Role of glyceraldehyde 3-phosphate dehydrogenase in the development and progression of diabetic retinopathy. Diabetes. 2009;58(1):227-234.
Poltorak V.V., Bloh K.O., Malashenko A.M. Jeksperimental'noe modelirovanie saharnogo diabeta dlja izuchenija specificheskogo jeffekta novyh antidiabeticheskih veshhestv (Metod. rekomend.). Har'kov, 1991. 20 s.
Pasechnikova N. V. Zashhitnoe dejstvie kvercetina i lipoata na funkcional'nye gruppy belkov setchatki pri modelirovanii diabeta / N.V. Pasechnikova, O.A. Moroz // Oftal'mologіchnij zhurnal. – 2015. – № 3. – S. 76-81
Jeksperimental'naja model' saharnogo diabeta 2-go tipa u krys, vyzvannaja dietoj s vysokim soderzhaniem zhirov i streptozotocinom v nizkoj doze / O.A. Kajdash, V.V. Ivanov, A.I. Vengerovskij, E.E. Bujko, I.A. Shhepetkin // Bjulleten' sibirskoj mediciny. – 2020. – №19(2). – S.41-47.
Rol' metformina v profilaktike diabeticheskoj nefropatii pri jeksperimental'nom saharnom diabete 2 tipa / V.K. Bajrasheva, A.Ju. Babenko, Ju.V. Dmitriev, A.A.Bajramov, S.G. Chefu, I.S. Shatalov, A.N. Aref'eva, I.Ju. Pchelin, N.V. Hudjakova, P.G. Aliev, E.N. Grineva // Regionarnoe krovoobrashhenie i mikrocirkuljacija. – 2016. – №15(3). – S.70-80.
Pokrovskij M.V. Jendotelioprotektornye jeffekty L-arginina pri modelirovanii deficita okisi azota / M.V. Pokrovskij, T.G. Pokrovskaja V.I. Korchakov // Jeksperimental'naja i klinicheskaja farmakologija. – 2008. – № 71 (2). – S. 29–31.
Efficacy of Subconjunctival Aflibercept Versus Bevacizumab for Prevention of Corneal Neovascularization in a Rat Model / Orly Gal-Or 1, Eitan Livny, Ruti Sella, Yael Nisgav, Dov Weinberger, Tami Livnat, Irit Bahar // Cornea. – 2016. – Vol. 3. – Issue 7. – R. 991-996.
Savytskyi. I. V.; Levytskyi, I. M.; Levytska, G. V.; Miastkivska, I. V.; Kuzmenko, I. A. Dynamics of vasoconstriction and vasodilation potential on the background of experimental rhegmatogenous retinal detachment and its correction. Journal of Education, Health and Sport 2016, 6 (2), p. 367-375.
Pavlova O. N. Issledovanie dinamiki aktivnosti katalazy v syvorotke krovi krys pri mehanicheskom vozdejstvii na gematooftal'micheskij bar'er / O. N. Pavlova, O. N. Gulenko, R. G. Karimova i dr. // Mezhdunarodnyj nauchno-issledovatel'skij zhurnal. — 2020. — № 5 (95) Chast' 1. – S.153—158.
Bykov I.L. Vlijanie L-karnitina na metabolicheskie narushenija pri jeksperimental'noj nedostatochnosti acil-KoA degidrogenaz/ I.L. Bykov // Jeksperimental'naja i klinicheskaja farmakologija. – 2004. – Tom 67 – № 6. S.48-52.
Dzugkoev S. G. Vlijanie kojenzima Q 10, afobazola i L-karnitina na jendotelial'nuju funkciju u krys s jeksperimental'nym saharnym diabetom / S.G. Dzugkoev, F.S. Dzugkoeva, N.V. Gumanova, V.A. Metel'skaja // Kubanskij nauchnyj medicinskij vestnik. – 2012. – №3 (132). – S.48-51.
Sirman Ya. V., Preys N. I., Savitsky I. V., Badiuk N. S., Blavatska O. M, Hrytsan I. I., Tsypoviaz S. V. Dynamics of vasoconstructor-vasodilation potential on the background of the development of experimental diabetic retinopathy / PharmacologyOnLine; Archives - 2021 - vol.1 – 90-95.
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