Humanities
Skip to main content Skip to main navigation menu Skip to site footer
  • Register
  • Login
  • Menu
  • Home
  • Current
  • Archives
  • Announcements
  • About
    • About the Journal
    • Submissions
    • Editorial Team
    • Privacy Statement
    • Contact
  • Register
  • Login

Journal of Education, Health and Sport

Targeted therapy with histamine antagonists - New challenges to fight with breast cancer
  • Home
  • /
  • Targeted therapy with histamine antagonists - New challenges to fight with breast cancer
  1. Home /
  2. Archives /
  3. Vol. 12 No. 12 (2022) /
  4. Research Articles

Targeted therapy with histamine antagonists - New challenges to fight with breast cancer

Authors

  • Piotr Jan Więsyk Students' Research Group at the Department of Family Medicine ,Medical University of Lublin https://orcid.org/0000-0001-6785-6741
  • Paulina Oleksa Students' Research Group at the Department of Family Medicine ,Medical University of Lublin https://orcid.org/0000-0002-3474-6156
  • Zuzanna Chilimoniuk Students' Research Group at the Department of Family Medicine ,Medical University of Lublin https://orcid.org/0000-0001-8261-0192
  • Maciej Dobosz Students' Research Group at the Department of Family Medicine ,Medical University of Lublin https://orcid.org/0000-0002-4413-3310
  • Maciej Sobczyk Students' Research Group at the Department of Family Medicine ,Medical University of Lublin https://orcid.org/0000-0003-1857-2413
  • Małgorzata Słaboń Students' Research Group at the Department of Family Medicine ,Medical University of Lublin https://orcid.org/0000-0003-1627-8878

DOI:

https://doi.org/10.12775/JEHS.2022.12.12.013

Keywords

Histamine, Histamine Receptors, Breast cancer

Abstract

Breast cancer (BC) is currently the most commonly diagnosed cancer in women. BC is most often derived from the epithelial tissue of the mammary gland and is a global problem due to the steady increase in morbidity and mortality in most countries. A particular problem today is the triple negative subtype (TNBC), which accounts for approximately 10-15% of breast cancer cases. BC occurs most frequently in young women and is characterised by various biological characteristics, an unfavourable clinical course and a poor prognosis. Recent studies to detect the effects of histamine receptors on breast cancer have shown that all H1R-H4R receptors are also hyperactive in the cancer microenvironment. Chronically maintaining a high level of histamine in the tumour-affected tissue contributes to increased angiogenesis at this site, induction of cancer cells proliferation and T lymphocyte dysfunction. The rising incidence of breast cancer is contributing to an increasing amount of research into targeted therapies. Studies on the effect of histamine antagonists through H1R-H4R receptors have proven their effectiveness in the treatment of breast cancer. Among those in the study, there was a reduction in tumour growth, cell proliferation and an increase in apoptosis. The use of histamine antagonists also contributed to a reduced risk of death from breast cancer and increased overall survival (OS). Therefore, targeted therapy is needed to improve the prognosis of patients with breast cancer. 

References

Koch MK, Murekatete B, Hutmacher DW, Haupt LM, Bray LJ. Label-free isolation and cultivation of patient-matched human mammary epithelial and stromal cells from normal breast tissue. Eur J Cell Biol. 2021;100(7-8):151187. doi:10.1016/j.ejcb.2021.151187

Fahad Ullah M. Breast Cancer: Current Perspectives on the Disease Status. Adv Exp Med Biol. 2019;1152:51-64. doi:10.1007/978-3-030-20301-6_4

Ahmad A. Breast Cancer Statistics: Recent Trends. Adv Exp Med Biol. 2019;1152:1-7. doi:10.1007/978-3-030-20301-6_1

Azamjah N, Soltan-Zadeh Y, Zayeri F. Global Trend of Breast Cancer Mortality Rate: A 25-Year Study. Asian Pac J Cancer Prev. 2019;20(7):2015-2020. Published 2019 Jul 1. doi:10.31557/APJCP.2019.20.7.2015

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [published correction appears in CA Cancer J Clin. 2020 Jul;70(4):313]. CA Cancer J Clin. 2018;68(6):394-424. doi:10.3322/caac.21492

Akram M, Iqbal M, Daniyal M, Khan AU. Awareness and current knowledge of breast cancer. Biol Res. 2017;50(1):33. Published 2017 Oct 2. doi:10.1186/s40659-017-0140-9

Won KA, Spruck C. Triple‑negative breast cancer therapy: Current and future perspectives (Review). Int J Oncol. 2020;57(6):1245-1261. doi:10.3892/ijo.2020.5135

Griffiths CL, Olin JL. Triple negative breast cancer: a brief review of its characteristics and treatment options. J Pharm Pract. 2012;25(3):319-323. doi:10.1177/0897190012442062

Nguyen PL, Cho J. Pathophysiological Roles of Histamine Receptors in Cancer Progression: Implications and Perspectives as Potential Molecular Targets. Biomolecules. 2021;11(8):1232. Published 2021 Aug 18. doi:10.3390/biom11081232

Obara I, Telezhkin V, Alrashdi I, Chazot PL. Histamine, histamine receptors, and neuropathic pain relief. Br J Pharmacol. 2020;177(3):580-599. doi:10.1111/bph.14696

Tanaka S, Furuta K. Roles of IgE and Histamine in Mast Cell Maturation. Cells. 2021;10(8):2170. Published 2021 Aug 23. doi:10.3390/cells10082170

Jurič DM, Kržan M, Lipnik-Stangelj M. Histamine and astrocyte function. Pharmacol Res. 2016;111:774-783. doi:10.1016/j.phrs.2016.07.035

Schirmer B, Neumann D. The Function of the Histamine H4 Receptor in Inflammatory and Inflammation-Associated Diseases of the Gut. Int J Mol Sci. 2021;22(11):6116. Published 2021 Jun 6. doi:10.3390/ijms22116116

Branco ACCC, Yoshikawa FSY, Pietrobon AJ, Sato MN. Role of Histamine in Modulating the Immune Response and Inflammation. Mediators Inflamm. 2018;2018:9524075. Published 2018 Aug 27. doi:10.1155/2018/9524075

Sarasola MP, Táquez Delgado MA, Nicoud MB, Medina VA. Histamine in cancer immunology and immunotherapy. Current status and new perspectives. Pharmacol Res Perspect. 2021;9(5):e00778. doi:10.1002/prp2.778

Ku HJ, Kim HY, Kim HH, Park HJ, Cheong JH. Bile acid increases expression of the histamine-producing enzyme, histidine decarboxylase, in gastric cells. World J Gastroenterol. 2014;20(1):175-182. doi:10.3748/wjg.v20.i1.175

Nicoud MB, Sterle HA, Massari NA, et al. Study of the antitumour effects and the modulation of immune response by histamine in breast cancer. Br J Cancer. 2020;122(3):348-360. doi:10.1038/s41416-019-0636-x

Medina VA, Rivera ES. Histamine receptors and cancer pharmacology. Br J Pharmacol. 2010;161(4):755-767. doi:10.1111/j.1476-5381.2010.00961.x

Derakhshan T, Bhowmick R, Ritchey JW, Gappa-Fahlenkamp H. Development of Human Mast Cells from Hematopoietic Stem Cells within a 3D Collagen Matrix: Effect of Stem Cell Media on Mast Cell Generation. Stem Cells Int. 2018;2018:2136193. Published 2018 Jul 11. doi:10.1155/2018/2136193

Espinosa E, Valitutti S. New roles and controls of mast cells. Curr Opin Immunol. 2018;50:39-47. doi:10.1016/j.coi.2017.10.012

Lichterman JN, Reddy SM. Mast Cells: A New Frontier for Cancer Immunotherapy. Cells. 2021;10(6):1270. Published 2021 May 21. doi:10.3390/cells10061270

Joanna Kopeć-Szlęzak. Mast cells and their role in immunity and cancer. Journal of Transfusion Medicine 2015, tom 8, nr 2, 49–59

Oldford SA, Marshall JS. Mast cells as targets for immunotherapy of solid tumors. Mol Immunol. 2015;63(1):113-124. doi:10.1016/j.molimm.2014.02.020

Aponte-López A, Muñoz-Cruz S. Mast Cells in the Tumor Microenvironment. Adv Exp Med Biol. 2020;1273:159-173. doi:10.1007/978-3-030-49270-0_9

Komi DEA, Redegeld FA. Role of Mast Cells in Shaping the Tumor Microenvironment. Clin Rev Allergy Immunol. 2020;58(3):313-325. doi:10.1007/s12016-019-08753-w

Fakhrjou A, Naghavi-Behzad M, Montazeri V, Karkon-Shayan F, Norouzi-Panahi L, Piri R. The relationship between histologic grades of invasive carcinoma of breast ducts and mast cell infiltration [published correction appears in South Asian J Cancer. 2016 Jul-Sep;5(3):166]. South Asian J Cancer. 2016;5(1):5-7. doi:10.4103/2278-330X.179699

Aponte-López A, Fuentes-Pananá EM, Cortes-Muñoz D, Muñoz-Cruz S. Mast Cell, the Neglected Member of the Tumor Microenvironment: Role in Breast Cancer. J Immunol Res. 2018;2018:2584243. Published 2018 Feb 5. doi:10.1155/2018/2584243

Chen N, Feng Q, Deng J, et al. Hdc-expressing myeloid-derived suppressor cells promote basal-like transition and metastasis of breast cancer. Int J Clin Exp Pathol. 2020;13(6):1431-1443. Published 2020 Jun 1.

Diego J. Martinel Lamas, Elena S. Rivera, Vanina A. Medina. Histamine H4 receptor: insights into a potential therapeutic target in breast cancer. Front. Biosci. (Schol Ed) 2015, 7(1), 1–9. https://doi.org/10.2741/S420

Nguyen, P.L.; Cho, J. Pathophysiological Roles of Histamine Receptors in Cancer Progression: Implications and Perspectives as Potential Molecular Targets. Biomolecules 2021, 11, 1232. https://doi.org/10.3390/ biom11081232

Cricco GP, Davio CA, Martin G, et al. Histamine as an autocrine growth factor in experimental mammary carcinomas. Agents Actions. 1994;43(1-2):17-20. doi:10.1007/BF02005757

Davio CA, Cricco GP, Martin G, Fitzsimons CP, Bergoc RM, Rivera ES. Effect of histamine on growth and differentiation of the rat mammary gland. Agents Actions. 1994;41 Spec No:C115-C117. doi:10.1007/BF02007792

Fernández-Nogueira P, Bragado P, Almendro V, et al. Differential expression of neurogenes among breast cancer subtypes identifies high risk patients. Oncotarget. 2016;7(5):5313-5326. doi:10.18632/oncotarget.6543

Massari NA, Nicoud MB, Medina VA. Histamine receptors and cancer pharmacology: an update. Br J Pharmacol. 2020;177(3):516-538. doi:10.1111/bph.14535

García-Quiroz J, González-González ME, Díaz L, et al. ASTEMIZOLE, AN INHIBITOR OF ETHER-À-GO-GO-1 POTASSIUM CHANNEL, INCREASES THE ACTIVITY OF THE TYROSINE KINASE INHIBITOR GEFITINIB IN BREAST CANCER CELLS. Rev Invest Clin. 2019;71(3):186-194. doi:10.24875/RIC.18002840

García-Quiroz J, Camacho J. Astemizole: an old anti-histamine as a new promising anti-cancer drug. Anticancer Agents Med Chem. 2011;11(3):307-314. doi:10.2174/187152011795347513

García-Quiroz J, García-Becerra R, Barrera D, Santos N, Avila E, et al. (2012) Astemizole Synergizes Calcitriol Antiproliferative Activity by Inhibiting CYP24A1 and Upregulating VDR: A Novel Approach for Breast Cancer Therapy. PLOS ONE 7(9): e45063. https://doi.org/10.1371/journal.pone.0045063

Tanaka S, Sakaguchi M, Yoneyama H, Usami Y, Harusawa S. Histamine H3 receptor antagonist OUP-186 attenuates the proliferation of cultured human breast cancer cell lines. Biochem Biophys Res Commun. 2016;480(3):479-485. doi:10.1016/j.bbrc.2016.10.077

Nicoud MB, Formoso K, Medina VA. Pathophysiological Role of Histamine H4 Receptor in Cancer: Therapeutic Implications. Front Pharmacol. 2019;10:556. Published 2019 Jun 5. doi:10.3389/fphar.2019.00556

Speisky D, Táquez Delgado MA, Iotti A, et al. Histamine H4 Receptor Expression in Triple-negative Breast Cancer: An Exploratory Study. J Histochem Cytochem. 2022;70(4):311-322. doi:10.1369/00221554221083670

Nicoud MB, Táquez Delgado MA, Sarasola MP, et al. Impact of histamine H4 receptor deficiency on the modulation of T cells in a murine breast cancer model. Cancer Immunol Immunother. 2021;70(1):233-244. doi:10.1007/s00262-020-02672-y

Bowrey PF, King J, Magarey C, et al. Histamine, mast cells and tumour cell proliferation in breast cancer: does preoperative cimetidine administration have an effect?. Br J Cancer. 2000;82(1):167-170. doi:10.1054/bjoc.1999.0895

Sterle HA, Nicoud MB, Massari NA, et al. Immunomodulatory role of histamine H4 receptor in breast cancer. Br J Cancer. 2019;120(1):128-138. doi:10.1038/s41416-018-0173-z

Grauers Wiktorin H, Nilsson MS, Kiffin R, et al. Histamine targets myeloid-derived suppressor cells and improves the anti-tumor efficacy of PD-1/PD-L1 checkpoint blockade. Cancer Immunol Immunother. 2019;68(2):163-174. doi:10.1007/s00262-018-2253-6

Bens A, Dehlendorff C, Friis S, et al. The role of H1 antihistamines in contralateral breast cancer: a Danish nationwide cohort study. Br J Cancer. 2020;122(7):1102-1108. doi:10.1038/s41416-020-0747-4

Patricia Fernández-Nogueira, Aleix Noguera-Castells, Gemma Fuster, et. al Histamine receptor 1 inhibition enhances antitumor therapeutic responses through extracellular signal-regulated kinase (ERK) activation in breast cancer,Cancer Letters, Volume 424, 2018, Pages 70-83, ISSN 0304-3835, https://doi.org/10.1016/j.canlet.2018.03.014.

Fernández-Nogueira P, Noguera-Castells A, Fuster G, et al. Histamine receptor 1 inhibition enhances antitumor therapeutic responses through extracellular signal-regulated kinase (ERK) activation in breast cancer. Cancer Lett. 2018;424:70-83. doi:10.1016/j.canlet.2018.03.014

Fritz I, Wagner P, Broberg P, Einefors R, Olsson H. Desloratadine and loratadine stand out among common H1-antihistamines for association with improved breast cancer survival. Acta Oncol. 2020;59(9):1103-1109. doi:10.1080/0284186X.2020.1769185

Ionov, Ilya D.a; Gorev, Nicholas P.b; Roslavtseva, Larissa A.b; Frenkel, David D.b. Cetirizine and thalidomide synergistically inhibit mammary tumorigenesis and angiogenesis in 7,12-dimethylbenz(a)anthracene-treated rats. Anti-Cancer Drugs: November 2018 - Volume 29 - Issue 10 - p 956-964 doi:10.1097/CAD.0000000000000670

Panagi M, Voutouri C, Mpekris F, et al. TGF-β inhibition combined with cytotoxic nanomedicine normalizes triple negative breast cancer microenvironment towards anti-tumor immunity. Theranostics. 2020;10(4):1910-1922. Published 2020 Jan 12. doi:10.7150/thno.36936

Li H, Xiao Y, Li Q, et al. The allergy mediator histamine confers resistance to immunotherapy in cancer patients via activation of the macrophage histamine receptor H1. Cancer Cell. 2022;40(1):36-52.e9. doi:10.1016/j.ccell.2021.11.002

Hellstrand K, Hermodsson S, Brune M, Naredi P, Carneskog J, Mellqvist UH. Histamine in cancer immunotherapy. Scand J Clin Lab Invest. 1997;57(3):193-202. doi:10.3109/00365519709060027

Galarza TE, Mohamad NA, Táquez Delgado MA, et al. Histamine prevents radiation-induced mesenchymal changes in breast cancer cells. Pharmacol Res. 2016;111:731-739. doi:10.1016/j.phrs.2016.07.039

Downloads

  • PDF

Published

2022-11-15

How to Cite

1.
WIĘSYK, Piotr Jan, OLEKSA, Paulina, CHILIMONIUK, Zuzanna, DOBOSZ, Maciej, SOBCZYK, Maciej and SŁABOŃ, Małgorzata. Targeted therapy with histamine antagonists - New challenges to fight with breast cancer. Journal of Education, Health and Sport. Online. 15 November 2022. Vol. 12, no. 12, pp. 87-93. [Accessed 5 July 2025]. DOI 10.12775/JEHS.2022.12.12.013.
  • ISO 690
  • ACM
  • ACS
  • APA
  • ABNT
  • Chicago
  • Harvard
  • IEEE
  • MLA
  • Turabian
  • Vancouver
Download Citation
  • Endnote/Zotero/Mendeley (RIS)
  • BibTeX

Issue

Vol. 12 No. 12 (2022)

Section

Research Articles

License

Copyright (c) 2022 Piotr Jan Więsyk, Paulina Oleksa, Zuzanna Chilimoniuk, Maciej Dobosz, Maciej Sobczyk, Małgorzata Słaboń

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

Stats

Number of views and downloads: 625
Number of citations: 0

Search

Search

Browse

  • Browse Author Index
  • Issue archive

User

User

Current Issue

  • Atom logo
  • RSS2 logo
  • RSS1 logo

Information

  • For Readers
  • For Authors
  • For Librarians

Newsletter

Subscribe Unsubscribe

Tags

Search using one of provided tags:

Histamine, Histamine Receptors, Breast cancer
Up

Akademicka Platforma Czasopism

Najlepsze czasopisma naukowe i akademickie w jednym miejscu

apcz.umk.pl

Partners

  • Akademia Ignatianum w Krakowie
  • Akademickie Towarzystwo Andragogiczne
  • Fundacja Copernicus na rzecz Rozwoju Badań Naukowych
  • Instytut Historii im. Tadeusza Manteuffla Polskiej Akademii Nauk
  • Instytut Kultur Śródziemnomorskich i Orientalnych PAN
  • Instytut Tomistyczny
  • Karmelitański Instytut Duchowości w Krakowie
  • Ministerstwo Kultury i Dziedzictwa Narodowego
  • Państwowa Akademia Nauk Stosowanych w Krośnie
  • Państwowa Akademia Nauk Stosowanych we Włocławku
  • Państwowa Wyższa Szkoła Zawodowa im. Stanisława Pigonia w Krośnie
  • Polska Fundacja Przemysłu Kosmicznego
  • Polskie Towarzystwo Ekonomiczne
  • Polskie Towarzystwo Ludoznawcze
  • Towarzystwo Miłośników Torunia
  • Towarzystwo Naukowe w Toruniu
  • Uniwersytet im. Adama Mickiewicza w Poznaniu
  • Uniwersytet Komisji Edukacji Narodowej w Krakowie
  • Uniwersytet Mikołaja Kopernika
  • Uniwersytet w Białymstoku
  • Uniwersytet Warszawski
  • Wojewódzka Biblioteka Publiczna - Książnica Kopernikańska
  • Wyższe Seminarium Duchowne w Pelplinie / Wydawnictwo Diecezjalne „Bernardinum" w Pelplinie

© 2021- Nicolaus Copernicus University Accessibility statement Shop