The proper functioning of the sense of smell and its disturbances on the example of COVID-19 infection
DOI:
https://doi.org/10.12775/JEHS.2022.12.04.026Keywords
COVID-19, SARS-Cov- 2, SARS-Cov- 2 infection, smell disturbances, olfactory disordersAbstract
COVD-19 disease causes a wide range of respiratory symptoms. One of them is the olfactory disorder, which is also associated with other viral infections. Impaired sense of smell is associated with damage to the respiratory epithelium. Sniffing problems lasting longer than a few days are reported by more than half of patients infected with SARSCov-2 virus. This problem affects the quality of life and may result, among other things, in eating disorders or an increase in exposure to harmful chemicals. The olfactory epithelium, containing receptor cells, is primarily responsible for the proper functioning of the sense of smell. Impaired smell in COVID 19 is associated with damage to the respiratory epithelium. The article is a review of the scientific literature, in which the issues related to the physiology and anatomical structure of the olfactory organ and the influence of SARSCov-2 virus infection on olfactory disorders were discussed.
References
Butowt R, Bilinska K. SARS-CoV-2: olfaction, brain infection, and the urgent need for clinical samples allowing earlier virus detection. ACS Chem Neurosci. 2020;11(9):1200–3.
Glezer I & Malnic B (2019) Olfactory receptor function. Handb Clin Neurol 164, 67–78.
Izquierdo-Dominguez A, Rojas-Lechuga MJ, Mullol J, Alobid I. Olfactory Dysfunction in the COVID-19 Outbreak. J Investig Allergol Clin Immunol. 2020;30(5):317-326. doi: 10.18176/jiaci.0567. Epub 2020 May 14. PMID: 32406374.
Jaume F, Quintó L, Alobid I, Mullol J. Overuse of diagnostic tools and medications in acute rhinosinusitis in Spain: a population-based study (the PROSINUS study). BMJ Open. 2018 Jan 31;8(1):e018788. doi: 10.1136/bmjopen-2017-018788. PMID: 29391364; PMCID: PMC5878244.
Klimek, L., Hagemann, J., Alali, A., Spielhaupter, M., Huppertz, T., Hörmann, K., Stielow, S., Freudelsperger, L. and Matthias, C. (2021), Telemedicine allows quantitative measuring of olfactory dysfunction in COVID-19. Allergy, 76: 868-870. https://doi.org/10.1111/all.14467.
Liu G, Zong G, Doty RL, Sun Q. Prevalence and risk factors of taste and smell impairment in a nationwide representative sample of the US population: a cross-sectional study. BMJ Open. 2016;6(11): e013246.
Li W, Li M, Ou G. COVID-19, cilia, and smell. FEBS J. 2020 Sep;287(17):3672-3676. doi: 10.1111/febs.15491. Epub 2020 Aug 6. PMID: 32692465; PMCID: PMC7426555.
Lukassen S, Chua RL, Trefzer T, Kahn NC, Schneider MA, Muley T, Winter H, Meister M, Veith C, Boots AW et al. (2020) SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells. EMBO J 39, e105114.
Mehraeen E, Behnezhad F, Salehi MA, Noori T, Harandi H, SeyedAlinaghi S. Olfactory and gustatory dysfunctions due to the coronavirus disease (COVID-19): a review of current evidence. Eur Arch Otorhinolaryngol. 2021 Feb;278(2):307-312. doi: 10.1007/s00405-020-06120-6. Epub 2020 Jun 17. PMID: 32556781; PMCID: PMC7297932.
Mirvis M, Siemers KA, Nelson WJ & Stearns TP (2019) Primary cilium loss in mammalian cells occurs predominantly by whole-cilium shedding. PLoS Biol 17, e3000381.
Mullol J, Alobid I, Mariño-Sánchez F, Izquierdo-Domínguez A, Marin C, Klimek L, Wang DY, Liu Z. The Loss of Smell and Taste in the COVID-19 Outbreak: a Tale of Many Countries. Curr Allergy Asthma Rep. 2020 Aug 3;20(10):61. doi: 10.1007/s11882-020-00961-1. PMID: 32748211; PMCID: PMC7397453.
Mullol J, Alobid I, Mariño-Sánchez F, Quintó L, de Haro J, Bernal-SprekelsenM, et al. Furthering the understanding of olfaction, prevalence of loss of smell and risk factors: a population-based survey (OLFACAT study). BMJ Open. 2012;2:e001256.
Reiter JF & Leroux MR (2017) Genes and molecular pathways underpinning ciliopathies. Nat Rev Mol Cell Biol 18, 533–547.
Sungnak W, Huang N, Becavin C, Berg M, Queen R,Litvinukova M, Talavera-Lopez C, Maatz H, Reichart D, Sampaziotis F et al. (2020) SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nat Med 26, 681–687.
Zhang Y, Mei T, Chen Y, Wang L, Jiang L, Liu K, Zhao L, Luo Z, Chi W, Zhu X. Smell disorders in COVID-19 patients: role of olfactory training: A protocol for systematic review and meta-analysis. Medicine (Baltimore). 2021 Feb 26;100(8):e24862. doi: 10.1097/MD.0000000000024862. PMID: 33663108; PMCID: PMC7909207.
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