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Journal of Education, Health and Sport

Malignant hyperthermia – state of knowledge
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Malignant hyperthermia – state of knowledge

Authors

  • Michał Perszke Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu https://orcid.org/0000-0002-8836-1462
  • Dominika Egierska Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu https://orcid.org/0000-0002-0465-5982
  • Kamil Cieślak Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu https://orcid.org/0000-0001-5606-7472
  • Miłosz Berliński Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu https://orcid.org/0000-0001-8132-7635
  • Witold Świenc Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu https://orcid.org/0000-0003-4292-1572
  • Oskar Tokarczuk Uniwersytet Medyczny w Lublinie https://orcid.org/0000-0003-3020-3266
  • Anna Walendzik Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu https://orcid.org/0000-0002-9579-3378

DOI:

https://doi.org/10.12775/JEHS.2022.12.09.102

Keywords

malignant hyperthermia, ryanodine receptor, succinylocholine, anesthetics

Abstract

Malignant hyperthermia (MH) is a relatively rare, but potentially lethal genetic disorder. That disease is characterized by hypermetabolic response of the skeletal muscles caused by exposure to triggering agents e.g. volatile anesthetics or depolarizing neuromuscular blockers.

The object of this article was to review and assess the most recent published works about the epidemiology, etiology, pathomechanism, therapy of the MH and the new advances in all these fields.

Authors scrutinized PubMed and Google Scholar using keywords: malignant hyperthermia, volatile anesthetics, ryanodine receptor mutation. In addition to this, the references of chosen articles were manually scoured for supplementary applicable articles. The literature was selected on the basis of a general medicine readership and prioritized clinical practice guidelines, systematic reviews and case reports.

The references include the latest reports on malignant hyperthermia, apart from works of historical importance.

Available treatment methods consist mainly of pharmacotherapy, symptomatic treatment and monitoring of vital parameters. Dantrolene is a first-choice drug in initial treatment of MH and is considered the only specific antidote.

In spite of the constant advances in the areas of medicine there is still much to be discovered about MH. Further studies are necessary, as the amount of credible evidence is not adequate.

References

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Published

2022-09-20

How to Cite

1.
PERSZKE, Michał, EGIERSKA, Dominika, CIEŚLAK, Kamil, BERLIŃSKI, Miłosz, ŚWIENC, Witold, TOKARCZUK, Oskar and WALENDZIK, Anna. Malignant hyperthermia – state of knowledge. Journal of Education, Health and Sport. Online. 20 September 2022. Vol. 12, no. 9, pp. 883-890. [Accessed 17 May 2025]. DOI 10.12775/JEHS.2022.12.09.102.
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Vol. 12 No. 9 (2022)

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Review Articles

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Copyright (c) 2022 Michał Perszke, Dominika Egierska, Kamil Cieślak, Miłosz Berliński, Witold Świenc, Oskar Tokarczuk, Anna Walendzik

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

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