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Journal of Education, Health and Sport

Hyaluronic acid in gynecology and obstetrics
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  3. Vol. 12 No. 4 (2022) /
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Hyaluronic acid in gynecology and obstetrics

Authors

  • Anna Małgorzata Łopuszyńska Student Scientific Association at Department of Epidemiology and Clinical Research Methodology Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080 https://orcid.org/0000-0001-5133-4180
  • Łukasz Ochyra Student Scientific Association at Department of Epidemiology and Clinical Research Methodology Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080 https://orcid.org/0000-0002-8586-3619
  • Mateusz Pawlicki Student Scientific Association at Department of Epidemiology and Clinical Research Methodology Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080 https://orcid.org/0000-0001-8318-6573
  • Halina Piecewicz-Szczęsna Department of Epidemiology and Clinical Research Methodology of the Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080 https://orcid.org/0000-0002-0573-7226

DOI:

https://doi.org/10.12775/JEHS.2022.12.04.028

Keywords

hyaluronic acid, gynecology, obstetrics

Abstract

Introduction: Hyaluronic acid (HA) is a polysaccharide classified in the group of glycosaminoglycans. Naturally it occurs in the dermis and is responsible for the elasticity of the skin. In medicine, it can be found cross-linked, partially cross-linked or non-cross-linked, which is associated with different densities and the ability to bind water molecules. It (HA) is used in many areas, including ophthalmology, rheumatology, and dermatology. There are many studies and reports, that it can be used in gynecology and obstetrics in various diseases.
Material and methods: The PubMed scientific base was reviewed in 2015-2022 using the keywords hyaluronic acid, gynecology, obstetrics.
Results: Intrauterine adhesions are a complication of various procedures performed in the uterine cavity, from curettage to removal of the septum or uterine fibroids. Numerous studies suggest, that hyaluronic acid may be an effective agent in preventing formation of adhesions. For menopausal women, it may relieve symptoms associated with vaginal atrophy. Indocyanine green is used for intraoperative visualization of neoplastic tissues and used in case of cervical cancer. There are reports, that stating hyaluronic acid can increase stability of this substance, which can improve imaging. In the case of hyaluronic acid in the form of vaginal gel, a beneficial effect on hydration and sexual function of women both after childbirth and after menopause was noticed. There are reports of its use in prevention of ovarian failure after chemotherapy and its positive aspects in assisted reproductive techniques.
Conclusions: Hyaluronic acid can be used in many gynecological and obstetric diseases, positively influencing the life of women in both fertility and sexual areas and also in the group of cancer patients. Therefore, further large, randomized, multicentre studies confirming action of this substance, determining its dose, method and schedule of administration are important.

References

Bayer IS. Hyaluronic Acid and Controlled Release: A Review. Molecules. 2020 Jun 6;25(11):2649. doi: 10.3390/molecules25112649. PMID: 32517278; PMCID: PMC7321085.

Abatangelo G, Vindigni V, Avruscio G, Pandis L, Brun P. Hyaluronic Acid: Redefining Its Role. Cells. 2020 Jul 21;9(7):1743. doi: 10.3390/cells9071743. PMID: 32708202; PMCID: PMC7409253.

Dreisler E, Kjer JJ. Asherman's syndrome: current perspectives on diagnosis and management. Int J Womens Health. 2019 Mar 20;11:191-198. doi: 10.2147/IJWH.S165474. PMID: 30936754; PMCID: PMC6430995.

Lee WL, Liu CH, Cheng M, Chang WH, Liu WM, Wang PH. Focus on the Primary Prevention of Intrauterine Adhesions: Current Concept and Vision. Int J Mol Sci. 2021 May 13;22(10):5175. doi: 10.3390/ijms22105175. PMID: 34068335; PMCID: PMC8153321.

Chen PC, Chen YP, Wu CC, Tseng CC, Yang CY, Hung YW, Wen ZH. A resorbable hyaluronic acid hydrogel to prevent adhesion in porcine model under laparotomy pelvic surgery. J Appl Biomater Funct Mater. 2021 Jan-Dec;19:2280800020983233. doi: 10.1177/2280800020983233. PMID: 33926290.

Xu X, Kong DS, Tian YP, Xie YL, Zhang JK, Huang XH. Autocross-linked hyaluronic acid gel and adipose-derived mesenchymal stem cell composites for the treatment intrauterine adhesions. Taiwan J Obstet Gynecol. 2021 Nov;60(6):1031-1037. doi: 10.1016/j.tjog.2021.09.014. PMID: 34794733.

Zhang Y, Liu Q, Yang N, Zhang X. Hyaluronic acid and oxidized regenerated cellulose prevent adhesion reformation after adhesiolysis in rat models. Drug Des Devel Ther. 2016 Oct 25;10:3501-3507. doi: 10.2147/DDDT.S103824. PMID: 27822014; PMCID: PMC5087760.

Liu F, Hu S, Yang H, Li Z, Huang K, Su T, Wang S, Cheng K. Hyaluronic Acid Hydrogel Integrated with Mesenchymal Stem Cell-Secretome to Treat Endometrial Injury in a Rat Model of Asherman's Syndrome. Adv Healthc Mater. 2019 Jul;8(14):e1900411. doi: 10.1002/adhm.201900411. Epub 2019 May 30. PMID: 31148407; PMCID: PMC7045702.

Tafti SZG, Javaheri A, Firoozabadi RD, Ashkezar SK, Abarghouei HF. Role of hyaluronic acid intrauterine injection in the prevention of Asherman's syndrome in women undergoing uterine septum resection: An RCT. Int J Reprod Biomed. 2021 Apr 22;19(4):339-346. doi: 10.18502/ijrm.v19i4.9060. PMID: 33997593; PMCID: PMC8106814.

Huang CY, Chang WH, Cheng M, Huang HY, Horng HC, Chen YJ, Lee WL, Wang PH. Crosslinked Hyaluronic Acid Gels for the Prevention of Intrauterine Adhesions after a Hysteroscopic Myomectomy in Women with Submucosal Myomas: A Prospective, Randomized, Controlled Trial. Life (Basel). 2020 May 15;10(5):67. doi: 10.3390/life10050067. PMID: 32429137; PMCID: PMC7280993.

Wang YQ, Song XH, Wu SL, Huang YZ, Yan L, Li CZ. Comparison of Autocross-Linked Hyaluronic Acid Gel and Intrauterine Device for Preventing Intrauterine Adhesions in Infertile Patients: A Randomized Clinical Trial. Gynecol Minim Invasive Ther. 2020 Apr 28;9(2):74-80. doi: 10.4103/GMIT.GMIT_103_19. PMID: 32676284; PMCID: PMC7354758.

Fei Z, Bin Z, Xin X, Fei H, Yuechong C. Meta-analysis on the use of hyaluronic acid gel to prevent recurrence of intrauterine adhesion after hysteroscopic adhesiolysis. Taiwan J Obstet Gynecol. 2019 Nov;58(6):731-736. doi: 10.1016/j.tjog.2019.09.002. PMID: 31759520.

Cheng M, Chang WH, Yang ST, Huang HY, Tsui KH, Chang CP, Lee WL, Wang PH. Efficacy of Applying Hyaluronic Acid Gels in the Primary Prevention of Intrauterine Adhesion after Hysteroscopic Myomectomy: A Meta-Analysis of Randomized Controlled Trials. Life (Basel). 2020 Nov 15;10(11):285. doi: 10.3390/life10110285. PMID: 33203159; PMCID: PMC7697815.

Zheng F, Xin X, He F, Liu J, Cui Y. Meta-analysis on the use of hyaluronic acid gel to prevent intrauterine adhesion after intrauterine operations. Exp Ther Med. 2020 Apr;19(4):2672-2678. doi: 10.3892/etm.2020.8483. Epub 2020 Feb 3. PMID: 32256748; PMCID: PMC7086218.

Lethaby A, Ayeleke RO, Roberts H. Local oestrogen for vaginal atrophy in postmenopausal women. Cochrane Database Syst Rev. 2016 Aug 31;2016(8):CD001500. doi: 10.1002/14651858.CD001500.pub3. PMID: 27577677; PMCID: PMC7076628.

Scavello I, Maseroli E, Di Stasi V, Vignozzi L. Sexual Health in Menopause. Medicina (Kaunas). 2019 Sep 2;55(9):559. doi: 10.3390/medicina55090559. PMID: 31480774; PMCID: PMC6780739.

Jokar A, Davari T, Asadi N, Ahmadi F, Foruhari S. Comparison of the Hyaluronic Acid Vaginal Cream and Conjugated Estrogen Used in Treatment of Vaginal Atrophy of Menopause Women: A Randomized Controlled Clinical Trial. Int J Community Based Nurs Midwifery. 2016 Jan;4(1):69-78. PMID: 26793732; PMCID: PMC4709811.

Berreni N, Salerno J, Chevalier T, Alonso S, Mares P. Evaluation of the effect of multipoint intra-mucosal vaginal injection of a specific cross-linked hyaluronic acid for vulvovaginal atrophy: a prospective bi-centric pilot study. BMC Womens Health. 2021 Aug 28;21(1):322. doi: 10.1186/s12905-021-01435-w. PMID: 34454465; PMCID: PMC8403403.

Carter J, Goldfarb S, Baser RE, Goldfrank DJ, Seidel B, Milli L, Saban S, Stabile C, Canty J, Gardner GJ, Jewell EL, Sonoda Y, Kollmeier MA, Alektiar KM. A single-arm clinical trial investigating the effectiveness of a non-hormonal, hyaluronic acid-based vaginal moisturizer in endometrial cancer survivors. Gynecol Oncol. 2020 Aug;158(2):366-374. doi: 10.1016/j.ygyno.2020.05.025. Epub 2020 Jun 8. PMID: 32522420; PMCID: PMC7423634.

Varytė G, Bartkevičienė D. Pelvic Radiation Therapy Induced Vaginal Stenosis: A Review of Current Modalities and Recent Treatment Advances. Medicina (Kaunas). 2021 Apr 1;57(4):336. doi: 10.3390/medicina57040336. PMID: 33915994; PMCID: PMC8066324.

Gustavino C, Sala P, Cusini N, Gravina B, Ronzini C, Marcolin D, Vellone VG, Paudice M, Nappi R, Costantini S, Ferrero S, Barra F. Efficacy and safety of prolonged-release hyaluronic acid derivative vaginal application in the postpartum period: a prospective randomised clinical trial. Ann Med. 2021 Dec;53(1):1589-1597. doi: 10.1080/07853890.2021.1974083. PMID: 34477473; PMCID: PMC8425721.

Choi S, Lee SH, Park S, Park SH, Park C, Key J. Indocyanine Green-Loaded PLGA Nanoparticles Conjugated with Hyaluronic Acid Improve Target Specificity in Cervical Cancer Tumors. Yonsei Med J. 2021 Nov;62(11):1042-1051. doi: 10.3349/ymj.2021.62.11.1042. PMID: 34672138; PMCID: PMC8542471.

Heymann D, Vidal L, Or Y, Shoham Z. Hyaluronic acid in embryo transfer media for assisted reproductive technologies. Cochrane Database Syst Rev. 2020 Sep 2;9(9):CD007421. doi: 10.1002/14651858.CD007421.pub4. PMID: 32876946; PMCID: PMC8941518.

Zhao G, Yan G, Cheng J, Zhou X, Fang T, Sun H, Hou Y, Hu Y. Hyaluronic acid prevents immunosuppressive drug-induced ovarian damage via up-regulating PGRMC1 expression. Sci Rep. 2015 Jan 6;5:7647. doi: 10.1038/srep07647. PMID: 25558795; PMCID: PMC4284510.

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Published

2022-04-30

How to Cite

1.
ŁOPUSZYŃSKA, Anna Małgorzata, OCHYRA, Łukasz, PAWLICKI, Mateusz and PIECEWICZ-SZCZĘSNA, Halina. Hyaluronic acid in gynecology and obstetrics . Journal of Education, Health and Sport. Online. 30 April 2022. Vol. 12, no. 4, pp. 335-340. [Accessed 3 July 2025]. DOI 10.12775/JEHS.2022.12.04.028.
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Vol. 12 No. 4 (2022)

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Review Articles

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Copyright (c) 2022 Anna Małgorzata Łopuszyńska, Łukasz Ochyra, Mateusz Pawlicki, Halina Piecewicz-Szczęsna

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