Effects of dupilumab on hair in patients with atopic dermatitis - a review of the literature
DOI:
https://doi.org/10.12775/JEHS.2022.12.11.043Keywords
dupilumab, atopic dermatitis, alopecia areata, side effect, monoclonal antibody, mollusum contagiosum, alopecia totalisAbstract
Dupilumab is a recombinant human monoclonal antibody of the IgG4 class. Its mechanism of action can most broadly be described as inhibition of interleukin 4 and 13-mediated signal transduction. These cytokines are the main drivers of inflammatory diseases such as atopic dermatitis (AD) and asthma. Currently, dupilumab is the subject of many studies and scientific articles. More and more papers are being written about the efficacy of this drug and the side effects. Based on publications from the PubMed database, we present selected cases of atopic dermatitis patients who experienced uncharacteristic and unclear hair-related changes, such as hair loss, growth and change in hair colour, after dupilumab administration.
References
Harb H, Chatila TA. Mechanisms of Dupilumab. Clin Exp Allergy. 2020 Jan;50(1):5-14. doi: 10.1111/cea.13491. Epub 2019 Sep 30. PMID: 31505066; PMCID: PMC6930967.
Hoy SM. Dupilumab: A Review in Chronic Rhinosinusitis with Nasal Polyps. Drugs. 2020 May;80(7):711-717. doi: 10.1007/s40265-020-01298-9. PMID: 32240527.
Gooderham MJ, Hong HC, Eshtiaghi P, Papp KA. Dupilumab: A review of its use in the treatment of atopic dermatitis. J Am Acad Dermatol. 2018 Mar;78(3 Suppl 1):S28-S36. doi: 10.1016/j.jaad.2017.12.022. PMID: 29471919.
Uchida H, Kamata M, Watanabe A, Agematsu A, Nagata M, Fukaya S, Hayashi K, Fukuyasu A, Tanaka T, Ishikawa T, Ohnishi T, Tada Y. Dupilumab Improved Alopecia Areata in a Patient with Atopic Dermatitis: A Case Report. Acta Derm Venereol. 2019 Jun 1;99(7):675-676. doi: 10.2340/00015555-3183. PMID: 30938821.
Kulkarni M, Rohan CA, Travers JB, Serrao R. Long-Term Efficacy of Dupilumab in Alopecia Areata. Am J Case Rep. 2022 Jun 21;23:e936488. doi: 10.12659/AJCR.936488. PMID: 35726185; PMCID: PMC9235915.
Sevray M, Dupré D, Misery L, Abasq-Thomas C. Hair regrowth and dissemination of molluscum contagiosum: two unexpected effects with dupilumab. J Eur Acad Dermatol Venereol. 2019 Aug;33(8):e296-e298. doi: 10.1111/jdv.15571. Epub 2019 Mar 29. PMID: 30875133.
Sugino H, Nakamura M. Mild hypertrichosis in both upper arms around dupilumab injection sites. Eur J Dermatol. 2021 Jun 1;31(3):420-421. doi: 10.1684/ejd.2021.4063. PMID: 34080975; PMCID: PMC8354836.
Ständer S, Trense Y, Thaçi D, Ludwig RJ. Alopecia areata development in atopic dermatitis patients treated with dupilumab. J Eur Acad Dermatol Venereol. 2020 Oct;34(10):e612-e613. doi: 10.1111/jdv.16493. Epub 2020 May 19. PMID: 32311803.
Salgüero-Fernández I, Gonzalez de Domingo MA, Suarez D, Roustan-Gullón G. Dermatitis and alopecia in a patient treated with dupilumab: a new adverse effect? Clin Exp Dermatol. 2019 Apr;44(3):e41-e43. doi: 10.1111/ced.13858. Epub 2018 Dec 9. PMID: 30536947.
Sumitomo C, Akita H, Sugiura K. Unexpected side-effect of dupilumab: Reversal of hair graying. J Dermatol. 2020 Sep;47(9):e316-e317. doi: 10.1111/1346-8138.15472. Epub 2020 Jun 23. PMID: 32578240.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Aleksandra Marczak, Michalina Hordejuk, Michał Hyjek, Karolina Szymkiewicz
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 514
Number of citations: 0
