The influence of drugs used in mental disorders on the health of the oral cavity - a systematic review
DOI:
https://doi.org/10.12775/JEHS.2023.13.01.006Keywords
kserostomia, depresja, antydepresanty, próchnica,, SSRI, TCAAbstract
Ze wzrostem liczby diagnoz zaburzeń psychicznych łączy się wzrost zapotrzebowania na leki psychotropowe, których częstym działaniem niepożądanym jest kserostomia, definiowana jako uczucie suchości w jamie ustnej i prowadząca m.in. do próchnicy i stanów zapalnych błon śluzowych. Największą zdolnością do wywoływania tych działań niepożądanych cechują się leki przeciwpsychotyczne i trójcykliczne leki przeciwdepresyjne, ale nie są od nich wolne także SSRI, antydepresanty atypowe i anksjolityki takie jak benzodiazepiny. W leczeniu kserostomii ważna jest profilaktyka kandydozy i próchnicy: odpowiednia dieta, prawidłowe zabiegi higienizacyjne oraz regularne kontrole stomatologiczne. Inne metody to farmakoterapia i stosowanie substytutów śliny. Istnieje korelacja pomiędzy zaburzeniami psychicznymi a wyższą liczbą ubytków próchnicowych, niższą jakością higieny jamy ustnej i większą częstością występowania chorób periodontologicznych.
References
Kisely S, Sawyer E, Siskind D, Lalloo R: The oral health of people with anxiety and depressive disorders – a systematic review and meta-analysis. J Affect Disord 2016; 200:119-132
Gahr M, Connemann JB, Schönfeldt-Lecuona C, Freudenmann WR, Stein JM, Hawlik AK: Psychiatrists' and dentists' knowledge and attitudes regarding adverse drug reactions of psychotropic drugs. Psychiatry Res 2018; 266:323-327
Millsop JW, Wang EA, Fazel N: Etiology, evaluation, and management of xerostomia. Clin Dermatol 2017; 35(5):468-476
Turner MD: Hyposalivation and Xerostomia Etiology, Complications, and Medical Management. Dent Clin North Am 2016; 60(2):435-443
Malhi GS, Mann JJ: Depression. Lancet 2018; 392:2299-2312
Grover SS, Rhodus NL Xerostomia and Depression. Northwest Dent 2016; 95(3):29,
, 33-35
Rheker J, Winkler A, Doering BK, Rief W Learning to experience side effects after
antidepressant intake – Results from a randomized, controlled, double-blind study.
; 234(3):329-338
Song SA, Choksawad K, Franco RA Jr. The Effectiveness of Nortriptyline and
Tolerability of Side Effects in Neurogenic Cough Patients. Ann Otol Rhinol Laryngol
; 130(7): 781-787
Henry NL, Banerjee M, Wicha M, Van Poznak C, Smerage JB, Schott AF, Griggs JJ,
Hayes DF Pilot study of duloxetine for treatment of aromatase inhibitor-associated
musculoskeletal symptoms. Cancer 2011; 117(24):5469-5475
Cho MA, Ko JY, Kim YK, Kho HS Salivary flow rate and clinical characteristics of
patients with xerostomia according to its aetiology. J Oral Rehabil 2010
Guobis Ž, Kareivienė V, Basevičienė N, Paipalienė P, Niedzelskienė I, Sabalys G,
Kubilius R, Gervickas A Microflora of the oral cavity in patients with xerostomia.
Medicina (Kaunas) 2011; 47(12):646-651
Daily C: Oral and dental effects of antidepressants. Aust Presc 2016; 39(3):84
Tanasiewicz M, Hildebrandt T, Obersztyn I: Xerostomia of various etiologies: a review
of the literature. Adv Clin Exp Med. 2016; 25(1):199-206
Raghavan SA, Puttaswamiah RN, Birur PN, Ramaswamy B, Sunny SP: Antidepressant-
induced burning mouth syndrome: a unique case. Korean J Pain 2014 27(3): 294-296
Cappetta K, Beyer C, Johnson JA, Bloch MH: Meta-analysis: Risk of dry mouth with second generation antidepressants. Prog Neuropsychopharmacol Biol Psychiatry 2018; 8:282-293
Tan ECK, Lexomboon D, Häbel H, Fastbom J, Eriksdotter M, Johnell K, Sandborgh- Englund G: Validating a model for medication-related dental outcomes in older people. Oral Dis 2022; 28(6):1697-1704
Johnsson M, Winder M, Zawia H, Lödöen I, Tobin G, Götrick B: In vivo studies of effects of antidepressants on parotid salivary secretion in the rat. Arch Oral Biol 2016;67:54-60
Qiu BY, Qiao JX, Yong J: Meta-analysis of Selective Serotonin Reuptake Inhibitors (SSRIs) Compared to Tricyclic Antidepressants (TCAs) in the Efficacy and Safety of Anti-depression Therapy in Parkinson's Disease(PD) Patients. Iran J Pharm Res 2014; 13(4)1213-1219.
Thomson WM, Ferguson CA, Janssens BE, Kerse NM, Ting GS, Smith MB: Xerostomia and polypharmacy among dependent older New Zealanders: a national survey. Age Ageing 2021; 8;50(1):248-251
Ouanounou A, Ng K: Medical management, orofacial findings, and dental care for the client with major depressive disorder. Can J Dent Hyg 2019; 1;53(3):172-177
Mattioli TM, Silva Sd, Grégio AM, Machado MÂ, Lima AA, Alanis LR: The effects of antidepressants and pilocarpine on rat parotid glands: an immunohistochemical study. Clinics (Sao Paulo) 2011; 66(9):1605-10
de Campaigno EP, Kebir I, Montastruc JL, Rueter M, Maret D, Lapeyre-Mestre M, Sallerin B, Despas F: Drug-Induced Dental Caries: A Disproportionality Analysis Using Data from VigiBase. Drug Saf 2017; 40(12):1249-1258
Nährlich L, Mainz JG, Adams C, Engel C, Herrmann G, Icheva V, Lauer J, Deppisch C, Wirth A, Unger K, Graepler-Mainka U, Hector A, Heyder S, Stern M, Döring G, Gulbins E, Riethmüller J: Therapy of CF-Patients with Amitriptyline and Placebo - a Randomised, Double-Blind, Placebo-Controlled Phase IIb Multicenter, Cohort-Study. Cell Physiol Biochem 2013: 31(4-5):505-512
Bonnet U, Khalil-Boutros Y: Acute Bilateral Parotitis Occurring during Venlafaxine Titration in an Adolescent Female with Major Depression. Pharmacopsychiatry 2014; 47(1):36-8
Johanson CN, Österberg T, Lernfelt B, Ekström J, Birkhed D: Salivary secretion and drug treatment in four 70-year-old Swedish cohorts during a period of 30 years. Gerodontology 2015; 32(3):202-10
Cockburn N, Pradhan A, Taing MW, Kisely S, Ford PJ: Oral health impacts of medications used to treat mental illness. J Affect Disord 2017; 1;223:184-193
Donaldson M, Goodchild JH: A Systematic Approach to Xerostomia Diagnosis and Management. Compend Contin Educ Dent 201;39:1-9
Łysik D, Niemirowicz-Laskowska K, Bucki R, Tokajuk G, Mystkowska J: Artificial Saliva: Challenges and Future Perspectives for the Treatment of Xerostomia. Int J Mol Sci. 2019; 29;20(13):3199
Jovanovic S, Milovanovic SD, Gajic I, Mandic J, Latas M, Jankovic L: Oral Health Status of Psychiatric In-patients in Serbia and Implications for Their Dental Care. Croat Med J 2010; 51(5):443-450
Kareem O, Ijaz B, Anjum S, Hadayat S, Tariq I, Younis M: Association of depression with dental caries and periodontal disease at a tertiary care hospital. J Pak Med Assoc 2021; 71(5):1345-1349
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