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Journal of Education, Health and Sport

Diagnosis and treatment of small intestinal bacterial overgrowth
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Diagnosis and treatment of small intestinal bacterial overgrowth

Authors

  • Karolina Zadrozna Samodzielny Publiczny Szpital Kliniczny nr 4 w Lublinie https://orcid.org/0000-0002-2374-6994
  • Olga Wysokińska Samodzielny Publiczny Szpital Kliniczny w Lublinie nr 4 https://orcid.org/0000-0002-9679-9958
  • Anna Małek Samodzielny Publiczny Szpital Kliniczny w Lublinie nr 4 https://orcid.org/0000-0003-0484-9960
  • Klara Iwaniszyn-Zapołoch Samodzielny Publiczny Szpital Kliniczny w Lublinie nr 4 https://orcid.org/0000-0003-1243-9021
  • Bartłomiej Wójcik Uniwersytecki Szpital Kliniczny im. Wojskowej Akademii Medycznej- Centralny Szpital Weteranów https://orcid.org/0000-0002-6118-9199
  • Mateusz Fabiś Wojewódzki Szpital Specjalistyczny im. M. Kopernika w Łodzi https://orcid.org/0000-0002-7150-1852
  • Justyna Żyga Wojewódzki Szpital Specjalistyczny im. Stefana Kardynała Wyszyńskiego w Lublinie Poland https://orcid.org/0000-0001-5453-1235

DOI:

https://doi.org/10.12775/JEHS.2022.12.12.006

Keywords

sibo, small intestinal bacterial overgrowth, IBS, probiotic, rifaximin, FODMAP

Abstract

Introduction:

The human digestive tract contains 38 trillion bacteria in the colon. Physiologically, there is much less of them in other parts of digestive tract. The concentration of bacterial colonies grows along the intestine. Small intestinal bacterial overgrowth (SIBO) is characterized by an increased number of bacteria in the small intestine that correlates with gastrointestinal symptoms. The main symptoms of SIBO are bdominal bloating and diarrhea. Diagnostic methods used in SIBO include measuring methane or hydrogen levels. However, the use of antibiotics is prevalent, there is still a necessity to search for the gold standard of treatment.

 

 

Objective:

The purpose of this paper is to review the current knowledge on the management of patients with proliferative small intestinal bacterial flora syndrome. Particular attention was paid to the types of diagnosis and treatment of this ailment in recent years.

 

Material and methods:

The review includes publications published in 2001- 2022. Data were collected using PubMed or az published online American College of Gastroenterology (ACG) 2020 guidelines.

 

Results:

SIBO is an incompletely understood disease. Its symptoms are nonspecific and found in many gastrointestinal disorders, and its diagnosis is not fully specified. The gold standard for diagnosis is the collection of a small bowel aspirate during endoscopic examination. Antibacterial treatment is given empirically, mainly rifaximin, while other types of treatment are not strongly established in the publications.

 

Conclusions:

The lack of standardized management and the lack of sufficient evidence for the effectiveness of current methods make SIBO a recurrent complaint. All above aspects confirm that SIBO requires a lot of research to provide better life quality for these patients.

References

https://www.mp.pl/gastrologia/wytyczne/245460,postepowanie-w-zespole-rozrostu-bakteryjnego-jelita-cienkiego. Dostęp: 05.09.2022 r.

Pimentel M, Saad RJ, Long MD, Rao SSC. ACG Clinical Guideline: Small Intestinal Bacterial Overgrowth. Am J Gastroenterol. 2020 Feb;115(2):165-178. doi: 10.14309/ajg.0000000000000501. PMID: 32023228.

Adike A, DiBaise JK. Small Intestinal Bacterial Overgrowth: Nutritional Implications, Diagnosis, and Management. Gastroenterol Clin North Am. 2018 Mar;47(1):193-208. doi: 10.1016/j.gtc.2017.09.008. Epub 2017 Dec 7. PMID: 29413012.

Rao SSC, Bhagatwala J. Small Intestinal Bacterial Overgrowth: Clinical Features and Therapeutic Management. Clin Transl Gastroenterol. 2019 Oct;10(10):e00078. doi: 10.14309/ctg.0000000000000078. PMID: 31584459; PMCID: PMC6884350.

Erdogan A, Rao SS, Gulley D, Jacobs C, Lee YY, Badger C. Small intestinal bacterial overgrowth: duodenal aspiration vs glucose breath test. Neurogastroenterol Motil. 2015 Apr;27(4):481-9. doi: 10.1111/nmo.12516. Epub 2015 Jan 19. PMID: 25600077.

Shah ED, Basseri RJ, Chong K, Pimentel M. Abnormal breath testing in IBS: a meta-analysis. Dig Dis Sci. 2010 Sep;55(9):2441-9. doi: 10.1007/s10620-010-1276-4. Epub 2010 May 14. PMID: 20467896.

Rezaie A, Buresi M, Lembo A, Lin H, McCallum R, Rao S, Schmulson M, Valdovinos M, Zakko S, Pimentel M. Hydrogen and Methane-Based Breath Testing in Gastrointestinal Disorders: The North American Consensus. Am J Gastroenterol. 2017 May;112(5):775-784. doi: 10.1038/ajg.2017.46. Epub 2017 Mar 21. PMID: 28323273; PMCID: PMC5418558.

Wielgosz-Grochowska JP, Domanski N, Drywień ME. Efficacy of an Irritable Bowel Syndrome Diet in the Treatment of Small Intestinal Bacterial Overgrowth: A Narrative Review. Nutrients. 2022 Aug 17;14(16):3382. doi: 10.3390/nu14163382. PMID: 36014888; PMCID: PMC9412469.

Zhong C, Qu C, Wang B, Liang S, Zeng B. Probiotics for Preventing and Treating Small Intestinal Bacterial Overgrowth: A Meta-Analysis and Systematic Review of Current Evidence. J Clin Gastroenterol. 2017 Apr;51(4):300-311. doi: 10.1097/MCG.0000000000000814. PMID: 28267052.

Nickles MA, Hasan A, Shakhbazova A, Wright S, Chambers CJ, Sivamani RK. Alternative Treatment Approaches to Small Intestinal Bacterial Overgrowth: A Systematic Review. J Altern Complement Med. 2021 Feb;27(2):108-119. doi: 10.1089/acm.2020.0275. Epub 2020 Oct 19. PMID: 33074705.

Ren X, Di Z, Zhang Z, Fu B, Wang Y, Huang C, Du Y. Chinese herbal medicine for the treatment of small intestinal bacterial overgrowth (SIBO): A protocol for systematic review and meta-analysis. Medicine (Baltimore). 2020 Dec 18;99(51):e23737. doi: 10.1097/MD.0000000000023737. PMID: 33371127; PMCID: PMC7748159.

Gatta L, Scarpignato C. Systematic review with meta-analysis: rifaximin is effective and safe for the treatment of small intestine bacterial overgrowth. Aliment Pharmacol Ther. 2017 Mar;45(5):604-616. doi: 10.1111/apt.13928. Epub 2017 Jan 12. PMID: 28078798; PMCID: PMC5299503.

https://www.mp.pl/interna/chapter/B16.II.4.12. Dostęp: 06.09.2022 r.

Wielgosz-Grochowska JP, Domanski N, Drywień ME. Efficacy of an Irritable Bowel Syndrome Diet in the Treatment of Small Intestinal Bacterial Overgrowth: A Narrative Review. Nutrients. 2022 Aug 17;14(16):3382. doi: 10.3390/nu14163382. PMID: 36014888; PMCID: PMC9412469.

Pimentel M, Constantino T, Kong Y, Bajwa M, Rezaei A, Park S. A 14-day elemental diet is highly effective in normalizing the lactulose breath test. Dig Dis Sci. 2004 Jan;49(1):73-7. doi: 10.1023/b:ddas.0000011605.43979.e1. PMID: 14992438.

Vanderhoof JA. Probiotics: future directions. Am J Clin Nutr. 2001 Jun;73(6):1152S-1155S. doi: 10.1093/ajcn/73.6.1152S. PMID: 11393194.

Marteau PR, de Vrese M, Cellier CJ, Schrezenmeir J. Protection from gastrointestinal diseases with the use of probiotics. Am J Clin Nutr. 2001 Feb;73(2 Suppl):430S-436S. doi: 10.1093/ajcn/73.2.430s. PMID: 11157353.

Quigley EM, Quera R. Small intestinal bacterial overgrowth: roles of antibiotics, prebiotics, and probiotics. Gastroenterology. 2006 Feb;130(2 Suppl 1):S78-90. doi: 10.1053/j.gastro.2005.11.046. PMID: 16473077.

McFarland LV. Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease. Am J Gastroenterol. 2006 Apr;101(4):812-22. doi: 10.1111/j.1572-0241.2006.00465.x. PMID: 16635227.

Thomas MR, Litin SC, Osmon DR, Corr AP, Weaver AL, Lohse CM. Lack of effect of Lactobacillus GG on antibiotic-associated diarrhea: a randomized, placebo-controlled trial. Mayo Clin Proc. 2001 Sep;76(9):883-9. doi: 10.4065/76.9.883. PMID: 11560298.

Shah SC, Day LW, Somsouk M, Sewell JL. Meta-analysis: antibiotic therapy for small intestinal bacterial overgrowth. Aliment Pharmacol Ther. 2013 Oct;38(8):925-34. doi: 10.1111/apt.12479. Epub 2013 Sep 4. PMID: 24004101; PMCID: PMC3819138.

Yuki M, Komazawa Y, Kobayashi Y, Kusunoki M, Takahashi Y, Nakashima S, Uno G, Ikuma I, Shizuku T, Kinoshita Y. Effects of Daikenchuto on Abdominal Bloating Accompanied by Chronic Constipation: A Prospective, Single-Center Randomized Open Trial. Curr Ther Res Clin Exp. 2015 May 4;77:58-62. doi: 10.1016/j.curtheres.2015.04.002. PMID: 27069528; PMCID: PMC4812817.

Kulich KR, Madisch A, Pacini F, Piqué JM, Regula J, Van Rensburg CJ, Ujszászy L, Carlsson J, Halling K, Wiklund IK. Reliability and validity of the Gastrointestinal Symptom Rating Scale (GSRS) and Quality of Life in Reflux and Dyspepsia (QOLRAD) questionnaire in dyspepsia: a six-country study. Health Qual Life Outcomes. 2008 Jan 31;6:12. doi: 10.1186/1477-7525-6-12. PMID: 18237386; PMCID: PMC2276197.

Chedid V, Dhalla S, Clarke JO, Roland BC, Dunbar KB, Koh J, Justino E, Tomakin E, Mullin GE. Herbal therapy is equivalent to rifaximin for the treatment of small intestinal bacterial overgrowth. Glob Adv Health Med. 2014 May;3(3):16-24. doi: 10.7453/gahmj.2014.019. PMID: 24891990; PMCID: PMC4030608.

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Published

2022-11-11

How to Cite

1.
ZADROZNA, Karolina, WYSOKIŃSKA, Olga, MAŁEK, Anna, IWANISZYN-ZAPOŁOCH, Klara, WÓJCIK, Bartłomiej, FABIŚ, Mateusz and ŻYGA, Justyna. Diagnosis and treatment of small intestinal bacterial overgrowth. Journal of Education, Health and Sport. Online. 11 November 2022. Vol. 12, no. 12, pp. 42-48. [Accessed 20 June 2025]. DOI 10.12775/JEHS.2022.12.12.006.
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Vol. 12 No. 12 (2022)

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Copyright (c) 2022 Karolina Zadrozna, Olga Wysokińska, Anna Małek, Klara Iwaniszyn-Zapołoch, Bartłomiej Wójcik, Mateusz Fabiś, Justyna Żyga

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