Role of autonomous and endocrine factors in immunotropic effects of nitrogenous metabolites in patients with chronic pyelonephritis
Keywordsbilirubin, uric acid, urea, creatinine, immunity, HRV, adaptation hormones, relationships, chronic pyelonephritis
Background. We have previously shown that nitrogenous metabolites have immunomodulatory effects in healthy rats and humans as well as patients with dysfunction of neuroendocrine-immune complex, encephalopatia and chronic pyelonephritis. The purpose of this study is clarification of the role of neuro-endocrine factors in their immunotropic activity in patients with chronic pyelonephritis. Materials and Methods. The object of observation were 17 men (aged 24-70 years) with chronic pyelonephritis in remission. The plasma levels and urinary excretion of nitrogenous metabolites as well as parameters of immunity and its neuro-endocrine regulation twice (on admission and after balneotherapy at the Truskavets’ Spa) was performed. Results. Judging by the multiple correlation coefficient, uricosuria exhibits maximal neuro-endocrine activity (R=0,780), followed by bilirubinemia (R=0,742), creatinineuria (R=0,692), uricemia (R=0,636), creatinineemia (R=0,632), urea excretion (R=0,536), instead urea plasma correlate with neuro-endocrine parameters insignificantly (R=0,360). Nitrogenous metabolites together determine the state of neuro-endocrine regulation by 94,2%, which, in turn, determine the state of immunity by 99,9%. Conclusion. Nitrogenous metabolites carry out immunomodulation in different ways: directly through aryl hydrocarbon (bilirubin), toll-like and adenosine (uric acid) receptors of immunocytes; through modulation of the activity of neurons of the autonomous nervous system and endocrinocytes with subsequent neuro-endocrine immunomodulation; and also, apparently, due to an off-receptor effect on neurons, endocrinocytes and immunocytes (urea and creatinine).
Akselrod S, Gordon D, Ubel FA, Shannon DC, Barger AC, Cohen RJ. Pоwer spectrum analysis rate fluctuation: a quantitative probe of beat-to-beat cardiovascular control. Science (NY). 1981; 213(4504): 220-222.
Baevskiy RM, Ivanov GG. Heart Rate Variability: theoretical aspects and possibilities of clinical application [in Russian]. Ultrazvukovaya i funktsionalnaya diagnostika. 2001; 3: 106-127.
Berntson GG, Bigger JT jr, Eckberg DL, Grossman P, Kaufman PG, Malik M, Nagaraja HN, Porges SW, Saul JP, Stone PH, Van der Molen MW. Heart Rate Variability: Origines, methods, and interpretive caveats. Psychophysiology. 1997; 34: 623-648.
Chrousos GP. The stress response and immune function: Clinical implications: Novera H. Spector Lecture. In: Neuroimmunomodulation. Perspectives at the new millennium / Ed by A Conti et al. Ann NYAS. 2000; 917:38-67.
Douglas SD, Quie PG. Investigation of Phagocytes in Disease. Churchil; 1981: 110.
Goldstein DS, Bentho O, Park MY, Sharabi Y. Low-frequency power of heart rate variability is not a measure of cardiac sympathetic tone but may be a measure of modulation of cardiac autonomic outflows by baroreflexes. Exp Physiol. 2011; 96(12): 1255-1261.
Goryachkovskiy АМ. Clinical Biochemistry [in Russian]. Odesa: Astroprint; 1998: 608.
Gozhenko AI. Essays on disease theory [in Russian]. Odesa; 2010: 24.
Gozhenko AI, Hrytsak YL, Barylyak LG, Kovbasnyuk MM, Tkachuk SP, KorolyshynTA, Matiyishyn GY, Zukow W, Popovych IL. Features of immunity by various constellations of principal adaptation hormones and autonomous regulation in practically healthy people. Journal of Education, Health and Sport. 2016; 6(10): 215-235.
Gozhenko АІ, Korda MM, Popadynets’ OO, Popovych IL. Entropy, Harmony, Synchronization and Their Neuro-Endocrine-Immune Correlates [in Ukrainian]. Odesa. Feniks; 2021: 232.
Gozhenko AI, Smagliy VS, Korda IV, Badiuk NS, Zukow W, Popovych IL. Functional relationships between parameters of uric acid exchange and immunity in female rats. Actual problems of transport medicine. 2019; 4(58): 123–131.
Gozhenko AI, Smagliy VS, Korda IV, Badiuk NS, Zukow W, Popovych IL. Features of immune status in different states of uric acid metabolism in female rats. Journal of Education, Health and Sport. 2019; 9(12): 167-180.
Gozhenko AI, Smagliy VS, Korda IV, Badiuk NS, Zukow W, Kovbasnyuk MM, Popovych IL. Relationships between parameters of uric acid exchange and immunity as well as microbiota in patients with neuroendocrine-immune complex dysfunction. Journal of Education, Health and Sport. 2020; 10(1): 165-175.
Gozhenko AI, Smagliy VS, Korda IV, Badiuk NS, Zukow W, Kovbasnyuk MM, Popovych IL. Relationships between changes in uric acid parameters metabolism and parameters of immunity and microbiota in patients with neuroendocrine-immune complex dysfunction. Journal of Education, Health and Sport. 2020; 10(2): 212-222.
Heart Rate Variability. Standards of Measurement, Physiological Interpretation, and Clinical Use. Task Force of ESC and NASPE. Circulation. 1996; 93(5): 1043-1065.
Ivassivka SV, Popovych IL, Aksentiychuk BI, Flyunt IS. Physiological Activity of Uric Acid and its Role in the Mechanism of Action of Naftussya Water [in Ukrainian]. Kyїv. Computerpress; 2004: 163.
Khaitov RM. Physiology of the Immune System [in Russian]. Мoskwa. VINITI RAS; 2005: 428.
Khaitov RM, Pinegin BV, Istamov KhI. Ecological Immunology [in Russian]. Мoskva. VNIRO; 1995: 219.
Korneva EA. Pathways of neuro-immune communication: past and present time, clinical application [in Russian]. Meditsinskaya Immunologiya. 2020; 22(3): 405-418.
Kuchma IL, Gozhenko AI, Bilas VR, Ruzhylo SV, Kovalchuk GY, Nahurna YV, Zukow W, Popovych IL. Immunotropic effects of nitrogenous metabolites (creatinine, urea, uric acid and bilirubin) in humans exposed to the factors of the accident at the Chоrnobyl nuclear power plant. Journal of Education, Health and Sport. 2020; 10(12): 314-331.
Kuchma IL, Gozhenko AI, Ruzhylo SV, Kovalchuk GY, Nahurna YV, Zukow W, Popovych IL. Immunotropic effects of nitrogenous metabolites in healthy humans. Journal of Education, Health and Sport. 2021; 11(5): 197-206.
Kuchma IL, Gozhenko AI, Flyunt I-SS, Ruzhylo SV, Zukow W, Popovych IL. Immunotropic effects of nitrogenous metabolites in patients with chronic pyelonephritis. Journal of Education, Health and Sport. 2021; 11(6): 217-226.
Kul’chyns’kyi AB, Kovbasnyuk MM, Korolyshyn TA, Kyjenko VM, Zukow W, Popovych IL. Neuro-immune relationships at patients with chronic pyelonephrite and cholecystite. Communication 2. Correlations between parameters EEG, HRV and Phagocytosis. Journal of Education, Health and Sport. 2016; 6(10): 377-401.
Lapovets’ LYe, Lutsyk BD. Handbook of Laboratory Immunology [in Ukrainian]. Kyїv. 2004: 173.
Markova OO, Popovych IL, Tserkovnyuk AV, Barylyak LG. Adrenaline Myocardiodystrophy and Body Reactivity [in Ukrainian]. Kyїv. Computerpress; 1997: 127
Perederiy VG, Zemskov AM, Bychkova NG, Zemskov VM. Immune status, principles of its evaluation and correction of immune disorders [in Russian]. Kyїv. Zdorovya; 1995: 211.
Popadynets’ OO, Gozhenko AI, Zukow W, Popovych IL. Relationships between the entropies of EEG, HRV, immunocytogram and leukocytogram. Journal of Education, Health and Sport. 2019; 9(5): 651-666.
Popоvych IL. Information effects of bioactive water Naftyssya in rats: modulation entropic, prevention desynchronizing and limitation of disharmonizing actions water immersion stress for information components of neuro-endocrine-immune system and metabolism, which correlates with gastroprotective effect [in Ukrainian]. Medical Hydrology and Rehabilitation. 2007; 5(3): 50-70.
Popovych IL, Flyunt IS, Alyeksyeyev OI, Barylyak LG, Bilas VR. Sanogenetic Bases of Rehabilitation on Spa Truskavets’ Urological Patients from Chornobylian Contingent [in Ukrainian]. Kyiv. Computerpress; 2003: 192.
Popovych IL, Gozhenko AI, Kuchma IL, Zukow W, Bilas VR, Kovalchuk GY, Ivasivka AS. Immunotropic effects of so-called slag metabolites (creatinine, urea, uric acid and bilirubin) at rats. Journal of Education, Health and Sport. 2020; 10(11): 320-336.
Popovych IL, Gozhenko AI, Zukow W, Polovynko IS. Variety of Immune Responses to Chronic Stress and their Neuro-Endocrine Accompaniment. Scholars' Press. Riga; 2020: 172.
Popovych IL, Gozhenko AI, Korda MM, Klishch IM, Popovych DV, Zukow W (editors). Mineral Waters, Metabolism, Neuro-Endocrine-Immune Complex. Odesa. Feniks; 2022: 252.
Reyes del Paso GA, Langewitz W, Mulder LJ, van Roon A, Duschek S. The utility of low frequency heart rate variability as an index of sympathetic cardiac tone: a review with emphasis on a reanalysis of previous studies. Psychophysiology. 2013; 50(5): 477-487.
Shaffer F, Ginsberg JP. An Overview of Heart Rate Variability Metrics and Norms. Front Public Health. 2017; 5: 258.
Shannon CE. A mathematical theory of information. Bell Syst Tech J. 1948; 27: 379-423.
Smagliy VS, Gozhenko AI, Korda IV, Badiuk NS, Zukow W, Kovbasnyuk MM, Popovych IL. Variants of uric acid metabolism and their immune and microbiota accompaniments in patients with neuroendocrine-immune complex dysfunction. Actual problems of transport medicine. 2020; 1(59): 114–125.
Sternberg EM. Neural regulation of innate immunity: a coordinated nonspecific response to pathogens. Nat Rev Immunol. 2006; 6(4): 318-328.
Taylor JA, Carr DL, Myers CW, Eckberg DL. Mechanisms underlying very-low-frequency RR-interval oscillations in humans. Circulation. 1998; 98(6): 547-555.
Thayer JF, Sternberg EM. Neural aspects of immunomodulation: Focus on the vagus nerve. Brain Behav Immun. 2010; 24(8): 1223-1228.
Theorell T, Liljeholm-Johansson Y, Björk H, Ericson M. Saliva testosterone and heart rate variability in the professional symphony orchestra after "public faintings" of an orchestra member. Psychoneuroendocrinology. 2007; 32(6): 660-668.
Valle-Mondragón del L, Becerra-Luna B, Cartas-Rosado R, et al. Correlation between Angiotensin Serum Levels and Very-Low-Frequency Spectral Power of Heart Rate Variability during Hemodialysis. Life (Basel). 2022; 12(7): 1020.
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