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Journal of Education, Health and Sport

Bupropion - an antidepressant drug with broad therapeutic potential
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Bupropion - an antidepressant drug with broad therapeutic potential

Authors

  • Sebastian Bróż Wojewódzki Szpital Specjalistyczny Nr 1 imienia Fryderyka Chopina w Rzeszowie https://orcid.org/0000-0002-6191-2535
  • Sara Dankiewicz Wojewódzki Szpital Specjalistyczny Nr 1 imienia Fryderyka Chopina w Rzeszowie https://orcid.org/0000-0002-9208-8462
  • Przemysław Żelazny 1 Wojskowy Szpital Kliniczny z Polikliniką SPZOZ w Lublinie https://orcid.org/0000-0001-6794-9112
  • Joanna Filipczak Absolwent Uniwersytetu Medycznego w Lublinie https://orcid.org/0000-0002-3512-8368
  • Aleksandra Swora Samodzielny Publiczny Szpital Kliniczny nr 1 w Lublinie https://orcid.org/0000-0002-6171-0386
  • Joanna Borowik Samodzielny Publiczny Szpital Kliniczny nr 1 w Lublinie https://orcid.org/0000-0001-8369-6207
  • Oliwer Sygacz Samodzielny Publiczny Szpital Kliniczny nr 4 w Lublinie https://orcid.org/0000-0003-3245-945X
  • Wojciech Brodowski Samodzielny Publiczny Zakład Opieki Zdrowotnej MSWiA w Lublinie https://orcid.org/0000-0003-0756-387X
  • Piotr Pawłowski Student, Faculty of Medicine, Medical University of Lublin https://orcid.org/0000-0002-1197-7218
  • Katarzyna Basta-Arciszewska Wojewódzki Szpital Specjalistyczny im. Stefana Kardynała Wyszyńskiego Samodzielny Publiczny Zakład Opieki Zdrowotnej w Lublinie | https://orcid.org/0000-0002-7759-1588

DOI:

https://doi.org/10.12775/JEHS.2022.12.09.070

Keywords

bupropion, depression, smoking cessation, obesity, ADHD

Abstract

Introduction: Bupropion is currently mainly used as an atypical antidepressant due to its psychotropic effects. In addition, it shows high potential in reducing withdrawal cravings in addicts, which is also used in the treatment of nicotinism. However, studies in recent years have shown that it may also be useful in other conditions.
Aim of the study: Our aim was to review the known usage of bupropion in the fields of psychiatry, neurology and internal medicine, and to identify potential directions for further research.
Methods and materials: We reviewed the literature available in the PubMed database, using the key words: "bupropion"; "depression"; "smoking cessation"; "obesity"; "ADHD".
Results: Bupropion- an antidepressant drug belonging to the group of selective norepinephrine and dopamine reuptake inhibitors. Bupropion is approved by the FDA(Food and Drug Administration) for the treatment of depression, seasonal affective disorder and nicotinism. The literature shows that it is also effective in off-label indications - treatment of antidepressant-induced sexual dysfunction, attention deficit hyperactivity disorder (ADHD), depression in bipolar disorder, obesity, neuropathic pain and cancer-related fatigue syndrome.
Conclusion: Due to the specific effects of bupropion, there are many more usage for the drug than the primary indications for which it is usually used. The usage of the drug described in the literature require additional studies on a larger group of patients.

References

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Trivedi MH, Walker R, Ling W, et al. Bupropion and Naltrexone in Methamphetamine Use Disorder. N Engl J Med. 2021 Jan 14;384(2):140-153. doi: 10.1056/NEJMoa2020214. PMID: 33497547; PMCID: PMC8111570.

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Berigan TR. The Many Uses of Bupropion and Bupropion Sustained Release (SR) in Adults. Prim Care Companion J Clin Psychiatry. 2002 Feb;4(1):30-32. doi: 10.4088/pcc.v04n0110a. PMID: 15014734; PMCID: PMC314381.

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Apovian CM, Aronne L, Rubino D, et al. COR-II Study Group. A randomized, phase 3 trial of naltrexone SR/bupropion SR on weight and obesity-related risk factors (COR-II). Obesity (Silver Spring). 2013 May;21(5):935-43. doi: 10.1002/oby.20309. PMID: 23408728; PMCID: PMC3739931.

Candler T, Kühnen P, Prentice AM et al. Epigenetic regulation of POMC; implications for nutritional programming, obesity and metabolic disease. Front Neuroendocrinol. 2019 Jul;54:100773. doi: 10.1016/j.yfrne.2019.100773. Epub 2019 Jul 22. PMID: 31344387.

Onakpoya IJ, Lee JJ, Mahtani KR et al. Naltrexone-bupropion (Mysimba) in management of obesity: A systematic review and meta-analysis of unpublished clinical study reports. Br J Clin Pharmacol. 2020 Apr;86(4):646-667. doi: 10.1111/bcp.14210. Epub 2020 Feb 4. PMID: 31918448; PMCID: PMC7098870.

Halseth A, Shan K, Gilder K et al. Quality of life, binge eating and sexual function in participants treated for obesity with sustained release naltrexone/bupropion. Obes Sci Pract. 2018 Feb 23;4(2):141-152. doi: 10.1002/osp4.156. PMID: 29670752; PMCID: PMC5893468.

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Published

2022-09-08

How to Cite

1.
BRÓŻ, Sebastian, DANKIEWICZ, Sara, ŻELAZNY, Przemysław, FILIPCZAK, Joanna, SWORA, Aleksandra, BOROWIK, Joanna, SYGACZ, Oliwer, BRODOWSKI, Wojciech, PAWŁOWSKI, Piotr and BASTA-ARCISZEWSKA, Katarzyna. Bupropion - an antidepressant drug with broad therapeutic potential. Journal of Education, Health and Sport. Online. 8 September 2022. Vol. 12, no. 9, pp. 591-598. [Accessed 16 June 2025]. DOI 10.12775/JEHS.2022.12.09.070.
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Vol. 12 No. 9 (2022)

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Review Articles

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Copyright (c) 2022 Sebastian Bróż, Sara Dankiewicz, Przemysław Żelazny, Joanna Filipczak, Aleksandra Swora, Joanna Borowik, Oliwer Sygacz, Wojciech Brodowski, Piotr Pawłowski, Katarzyna Basta-Arciszewska

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The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

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