Influence of selenium deficiency on the development of thyroid disorders - a literature review
DOI:
https://doi.org/10.12775/JEHS.2022.12.09.062Keywords
selenium, thyroid, selenium deficiency, thyroid disordersAbstract
Introduction and purpose: Selenium is essential for the proper course of many physiological and biochemical processes in the human body. It plays a large role in ensuring proper immunoendocrine function. The organ with the greatest amount of selenium per gram of tissue is the thyroid gland. This element builds enzymes involved in antioxidant processes - peroxidase, as well as deiodinases involved in the metabolism of thyroid hormones. There are scientific reports showing a beneficial effect of selenium supplementation in autoimmune diseases of the thyroid gland. The aim of this study is to summarize the current knowledge on the relationship between selenium deficiency and the development of thyroid dysfunction.
Description of the state of knowledge: There is a correlation between selenium deficiency and the functioning of the thyroid gland. It has been shown that selenium levels are often lowered in patients with autoimmune thyroiditis. Research shows that selenium supplementation may lower TPOAb and TgAb antibody levels in patients with Hashimoto's disease. In patients with Graves' orbitopathy, administration of selenium resulted in delayed progression of orbitopathy and less disease severity. There are reports that supplementation with this element may also increase the effectiveness of antithyroid drugs in patients with Graves-Basedow disease. There was also an association between selenium deficiency and the development of goiter and thyroid nodules.
Conclusions: Selenium plays an important role in the proper functioning of the thyroid gland. Although the specific role of selenium in the pathogenesis of thyroid disease is still under investigation, there are numerous reports saying that its deficiency may affect it. More research is needed on the relationship between selenium concentration and the regulation of thyroid function, because introducing it into the treatment regimen of thyroid disorders may give hope for better therapeutic effects.
References
Leonidas H. Duntas, Selenium and the Thyroid: A Close-Knit Connection, The Journal of Clinical Endocrinology & Metabolism, Volume 95, Issue 12, 1 December 2010, Pages 5180–5188, https://doi.org/10.1210/jc.2010-0191
Gorini, F.; Sabatino, L.; Pingitore, A.; Vassalle, C. Selenium: An Element of Life Essential for Thyroid Function. Molecules 2021, 26, 7084. https://doi.org/10.3390/molecules26237084
Rayman M, DPhil [Oxon], Selenium and human health, The Lancet, Volume 379, Issue 9822, P1256-1268, March 31, 2012 DOIL https://doi.org/10.1016/S0140-6736(11)61452-9
Mara Ventura, Miguel Melo, Francisco Carrilho, "Selenium and Thyroid Disease: From Pathophysiology to Treatment", International Journal of Endocrinology, vol. 2017, Article ID 1297658, 9 pages, 2017. https://doi.org/10.1155/2017/1297658
Mehdi Y, Hornick JL, Istasse L, Dufrasne I. Selenium in the environment, metabolism and involvement in body functions. Molecules. 2013 Mar 13;18(3):3292-311. doi: 10.3390/molecules18033292. PMID: 23486107; PMCID: PMC6270138.
Drutel, A., Archambeaud, F. and Caron, P. (2013), Selenium and the thyroid gland: more good news for clinicians. Clin Endocrinol, 78: 155-164. https://doi.org/10.1111/cen.12066
Hubalewska-Dydejczyk A, Duntas L, Gilis-Januszewska A. Pregnancy, thyroid, and the potential use of selenium. Hormones (Athens). 2020 Mar;19(1):47-53. doi: 10.1007/s42000-019-00144-2. Epub 2019 Nov 13. PMID: 31721136; PMCID: PMC7033058.
Rayman, M. (2008). Food-chain selenium and human health: Emphasis on intake. British Journal of Nutrition, 100(2), 254-268. doi:10.1017/S0007114508939830
Schomburg, L. The other view: the trace element selenium as a micronutrient in thyroid disease, diabetes, and beyond. Hormones 19, 15–24 (2020). https://doi.org/10.1007/s42000-019-00150-4
Yuan Z, Xu X, Ye H, Jin L, Zhang X, Zhu Y. High levels of plasma selenium are associated with metabolic syndrome and elevated fasting plasma glucose in a Chinese population: A case-control study. J Trace Elem Med Biol. 2015 Oct;32:189-94. doi: 10.1016/j.jtemb.2015.07.009. Epub 2015 Jul 26. PMID: 26302928.
R.C. Dickson, R.H. Tomlinson, Selenium in blood and human tissues, Clinica Chimica Acta, Volume 16, Issue 2, 1967, Pages 311-321, ISSN 0009-8981, https://doi.org/10.1016/0009-8981(67)90197-0
Nacamulli, D., Mian, C., Petricca, D., Lazzarotto, F., Barollo, S., Pozza, D., Masiero, S., Faggian, D., Plebani, M., Girelli, M.E., Mantero, F. and Betterle, C. (2010), Influence of physiological dietary selenium supplementation on the natural course of autoimmune thyroiditis. Clinical Endocrinology, 73: 535-539. https://doi.org/10.1111/j.1365-2265.2009.03758.x
Wu Q, Rayman MP, Lv H, Schomburg L, Cui B, Gao C, Chen P, Zhuang G, Zhang Z, Peng X, Li H, Zhao Y, He X, Zeng G, Qin F, Hou P, Shi B. Low Population Selenium Status Is Associated With Increased Prevalence of Thyroid Disease. J Clin Endocrinol Metab. 2015 Nov;100(11):4037-47. doi: 10.1210/jc.2015-2222. Epub 2015 Aug 25. PMID: 26305620.
Wang L, Wang B, Chen SR, Hou X, Wang XF, Zhao SH, Song JQ, Wang YG. Effect of Selenium Supplementation on Recurrent Hyperthyroidism Caused by Graves' Disease: A Prospective Pilot Study. Horm Metab Res. 2016 Sep;48(9):559-64. doi: 10.1055/s-0042-110491. Epub 2016 Jul 8. PMID: 27392116.
Leo M, Bartalena L, Rotondo Dottore G, Piantanida E, Premoli P, Ionni I, Di Cera M, Masiello E, Sassi L, Tanda ML, Latrofa F, Vitti P, Marcocci C, Marinò M. Effects of selenium on short-term control of hyperthyroidism due to Graves' disease treated with methimazole: results of a randomized clinical trial. J Endocrinol Invest. 2017 Mar;40(3):281-287. doi: 10.1007/s40618-016-0559-9. Epub 2016 Oct 12. PMID: 27734319.
Ventura M, Melo M, Carrilho F. Selenium and Thyroid Disease: From Pathophysiology to Treatment. Int J Endocrinol. 2017;2017:1297658. doi: 10.1155/2017/1297658. Epub 2017 Jan 31. PMID: 28255299; PMCID: PMC5307254.
Negro R, Greco G, Mangieri T, Pezzarossa A, Dazzi D, Hassan H. The influence of selenium supplementation on postpartum thyroid status in pregnant women with thyroid peroxidase autoantibodies. J Clin Endocrinol Metab. 2007 Apr;92(4):1263-8. doi: 10.1210/jc.2006-1821. Epub 2007 Feb 6. PMID: 17284630.
Rasmussen, Lone Banke, Lutz Schomburg, Josef Köhrle, Inge Bülow Pedersen, Birgit Hollenbach, Antonia Hög, Lars Ovesen, Hans Perrild, and Peter Laurberg. "Selenium status, thyroid volume, and multiple nodule formation in an area with mild iodine deficiency", European Journal of Endocrinology 164, 4 (2011): 585-590, accessed Aug 23, 2022, https://doi.org/10.1530/EJE-10-1026
Lenny H. E. Winkel, C. Annette Johnson, Markus Lenz, Tim Grundl, Olivier X. Leupin, Manouchehr Amini, and Laurent Charlet, Environmental Science & Technology 2012 46 (2), 571-579DOI: 10.1021/es203434d
Ambroziak U, Hybsier S, Shahnazaryan U, Krasnodębska-Kiljańska M, Rijntjes E, Bartoszewicz Z, Bednarczuk T, Schomburg L. Severe selenium deficits in pregnant women irrespective of autoimmune thyroid disease in an area with marginal selenium intake. J Trace Elem Med Biol. 2017 Dec;44:186-191. doi: 10.1016/j.jtemb.2017.08.005. Epub 2017 Aug 4. PMID: 28965575.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Anna Chmura, Patrycja Baciur, Katarzyna Skowrońska, Filip Białas, Kamil Pondel
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 443
Number of citations: 0
