The influence of dioxines on endometriosis development – study review
Keywordsendometriosis, dioxins, dioxin-like factors, aromatic hydrocarbon receptor, exposure
Introduction: Dioxins and dioxin-like polychlorinated biphenyls are considered to be among the most toxic to humans due to their persistence, resistance to degradation and chemical properties. Endometriosis is characterized by the presence of endometrial cells outside the uterine cavity showing secretory activity. It is one of the most common causes of pelvic pain and decreased fertility; is formed as a result of the action of hormonal and immune mechanisms. The exact etiology is unknown and multifactorial; risk factors for endometriosis include both family conditions and various environmental factors, including exposure to chemicals.
The aim of the study: Evaluation of the impact of dioxins on endometriosis development.
Materials and methods: A research was performed using Pubmed, Google Scholar and ResearchGate; we made review and meta-analysis of the most relevant studies.
Results: Dioxins can contribute to cancer development, which is well documented, as well as several conditions, such as sexual dysfunctions, oxidative stress and inflammation. Doxins have similar structure to steroid hormones, so their main target are male and female gonads, thyroid gland and other organs in which steroid hormones are produced.
Conclusions: Endometriosis is a multifactorial disease, whereas dioxins are strong poisons that have an adverse effect on live organisms. Many epidemiological studies suggest that dioxins may significantly contribute to the development of endometriosis.
Marinković, Natalija, Pašalić, Daria, Ferenčak, Goran, Gršković, Branka and Rukavina, Ana. "Dioxins and Human Toxicity" Archives of Industrial Hygiene and Toxicology, vol.61, no.4, 2010, pp.445-453. https://doi.org/10.2478/10004-1254-61-2010-2024
Mehedintu C, Plotogea MN, Ionescu S, Antonovici M. Endometriosis still a challenge. J Med Life. 2014 Sep 15;7(3):349-57. Epub 2014 Sep 25. PMID: 25408753; PMCID: PMC4233437.
Taylor HS, Kotlyar AM, Flores VA. Endometriosis is a chronic systemic disease: clinical challenges and novel innovations. Lancet. 2021 Feb 27;397(10276):839-852. doi: 10.1016/S0140-6736(21)00389-5. PMID: 33640070.
Sachedina A, Todd N. Dysmenorrhea, Endometriosis and Chronic Pelvic Pain in Adolescents. J Clin Res Pediatr Endocrinol. 2020 Feb 6;12(Suppl 1):7-17. doi: 10.4274/jcrpe.galenos.2019.2019.S0217. PMID: 32041388; PMCID: PMC7053437.
Ukrainets RV, Korneva YS. [Endometriosis of the ureter from the standpoint of implantation theory: some aspects of pathogenesis and clinical picture]. Urologiia. 2021 Mar;(1):126-130. Russian. PMID: 33818948.
Bois FY, Eskenazi B. Possible risk of endometriosis for Seveso, Italy, residents: an assessment of exposure to dioxin. Environ Health Perspect. 1994 May;102(5):476-7. doi: 10.1289/ehp.94102476. Erratum in: Environ Health Perspect 1994 Aug;102(8):627. PMID: 8593852; PMCID: PMC1567136.
Hernandez-Ochoa I, Karman BN, Flaws JA (2009) The role of the aryl hydrocarbon receptor in the female reproductive system. Biochem Pharmacol 77(4):547–559. 10.1016/j.bcp.2008.09.037
Stockinger B, Di Meglio P, Gialitakis M, Duarte JH. The aryl hydrocarbon receptor: multitasking in the immune system. Annu Rev Immunol. 2014;32:403-32. doi: 10.1146/annurev-immunol-032713-120245. PMID: 24655296.
Humphrey-Johnson A, Abukalam R, Eltom SE (2015) Stability of the aryl hydrocarbon receptor and its regulated genes in the low activity variant of Hepa-1 cell line. Toxicol Lett 233(2):59–67. 10.1016/j.toxlet.2015.01.016
Larigot L, Juricek L, Dairou J, Coumoul X (2018) AhR signaling pathways and regulatory functions. Biochim Open 7:1–9. 10.1016/j.biopen.2018.05.001
Fujii-Kuriyama Y, Kawajiri K (2010) Molecular mechanisms of the physiological functions of the aryl hydrocarbon (dioxin) receptor, a multifunctional regulator that senses and responds to environmental stimuli. Proc Jpn Acad Ser B Phys Biol Sci 86(1):40–53. 10.2183/pjab.86.40
Bock KW, Kohle C (2006) Ah receptor: dioxin-mediated toxic responses as hints to deregulated physiologic functions. Biochem Pharmacol 72(4):393–404. 10.1016/j.bcp.2006.01.017
Bertazzi PA, Bernucci I, Brambilla G, Consonni D, Pesatori A. The Seveso studies on early and long-term effects of dioxin exposure: a review. Environ Health Perspect 1998;106(Suppl 2):625-33
Rier SE, Martin DC, Bowman RE, Dmowski WP, Becker JL. Endometriosis in rhesus monkeys (Macaca mulatta) following chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fundam Appl Toxicol. 1993 Nov;21(4):433-41. doi: 10.1006/faat.1993.1119. PMID: 8253297.
Marinković N, Pašalić D, Ferenčak G, Gršković B, Stavljenić Rukavina A. Dioxins and human toxicity. Arh Hig Rada Toksikol. 2010 Dec;61(4):445-53. doi: 10.2478/10004-1254-61-2010-2024. PMID: 21183436.
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