Therapeutic potential of Lion's Mane (Hericium erinaceus) in neurological and cognitive disorders - a review of the literature
DOI:
https://doi.org/10.12775/JEHS.2022.12.09.058Keywords
hericum erinaceus, brain, neurological diseasesAbstract
Introduction:
Hericium erinaceus is a medicinal and culinary mushroom that is widely present in the countries of East Asia. Bioactive compounds derived from the fruiting body or its mycelium have many properties, including: antioxidant, antidiabetic, anti-inflammatory, as well as hypolipidemic properties. It also has the potential to treat neurological disorders as it contains neurotrophic compounds that can cross the blood-brain barrier.
Aim of the study: The aim of this work is to review scientific research on the potential properties of the H. erinaceus in treating diseases of the nervous system.
Results: Many studies have shown that Hericium erinaceus can bring the desired effects as a complementary treatment and be an alternative in the treatment of depressive and cognitive disorders and, due to its strong neuroprotective nature, be used in Alzheimer's disease or in post-traumatic brain injury. Most of the cited studies concern experiments carried out on animal models.
Conclusion: Due to the evidence of potentially neuroprotective properties of H. erinaceus, there is a need for further clinical trials in humans.
References
Chong PS, Fung ML, Wong KH, Lim LW. Therapeutic Potential of Hericium erinaceus for Depressive Disorder. Int J Mol Sci 2020, Vol 21, Page 163. 2019;21(1):163. doi:10.3390/IJMS21010163
Thongbai B, Rapior S, Hyde KD, Wittstein K, Stadler M. Hericium erinaceus, an amazing medicinal mushroom. Mycol Prog 2015 1410. 2015;14(10):1-23. doi:10.1007/S11557-015-1105-4
Lee KF, Tung SY, Teng CC, et al. Post-Treatment with Erinacine A, a Derived Diterpenoid of H. erinaceus, Attenuates Neurotoxicity in MPTP Model of Parkinson’s Disease. Antioxidants 2020, Vol 9, Page 137. 2020;9(2):137. doi:10.3390/ANTIOX9020137
Chiu CH, Chyau CC, Chen CC, et al. Erinacine A-Enriched Hericium erinaceus Mycelium Produces Antidepressant-Like Effects through Modulating BDNF/PI3K/Akt/GSK-3β Signaling in Mice. Int J Mol Sci 2018, Vol 19, Page 341. 2018;19(2):341. doi:10.3390/IJMS19020341
Li TJ, Lee TY, Lo Y, et al. Hericium erinaceus mycelium ameliorate anxiety induced by continuous sleep disturbance in vivo. BMC Complement Med Ther. 2021;21(1):1-10. doi:10.1186/S12906-021-03463-3/FIGURES/7
Limanaqi F, Biagioni F, Busceti CL, Polzella M, Fabrizi C, Fornai F. Potential Antidepressant Effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea. Antioxidants 2020, Vol 9, Page 234. 2020;9(3):234. doi:10.3390/ANTIOX9030234
Zhang Z, Liu RN, Tang QJ, Zhang JS, Yang Y, Shang XD. A new diterpene from the fungal mycelia of Hericium erinaceus. Phytochem Lett. 2015;11:151-156. doi:10.1016/J.PHYTOL.2014.12.011
Ryu S, Kim HG, Kim JY, Kim SY, Cho KO. Hericium erinaceus Extract Reduces Anxiety and Depressive Behaviors by Promoting Hippocampal Neurogenesis in the Adult Mouse Brain. https://home.liebertpub.com/jmf. 2018;21(2):174-180. doi:10.1089/JMF.2017.4006
Chong PS, Poon CH, Roy J, et al. Neurogenesis-dependent antidepressant-like activity of Hericium erinaceus in an animal model of depression. Chinese Med (United Kingdom). 2021;16(1):1-24. doi:10.1186/S13020-021-00546-8/FIGURES/9
Saitsu Y, Nishide A, Kikushima K, Shimizu K, Ohnuki K. Improvement of cognitive functions by oral intake of Hericium erinaceus. Biomed Res. 2019;40(4):125-131. doi:10.2220/BIOMEDRES.40.125
D’amico R, Salinaro AT, Fusco R, et al. Hericium erinaceus and Coriolus versicolor Modulate Molecular and Biochemical Changes after Traumatic Brain Injury. Antioxidants 2021, Vol 10, Page 898. 2021;10(6):898. doi:10.3390/ANTIOX10060898
Cordaro M, Salinaro AT, Siracusa R, et al. Key Mechanisms and Potential Implications of Hericium erinaceus in NLRP3 Inflammasome Activation by Reactive Oxygen Species during Alzheimer’s Disease. Antioxidants 2021, Vol 10, Page 1664. 2021;10(11):1664. doi:10.3390/ANTIOX10111664
Li IC, Chang HH, Lin CH, et al. Prevention of Early Alzheimer’s Disease by Erinacine A-Enriched Hericium erinaceus Mycelia Pilot Double-Blind Placebo-Controlled Study. Front Aging Neurosci. 2020;12:155. doi:10.3389/FNAGI.2020.00155/XML/NLM
Jang HJ, Kim JE, Jeong KH, Lim SC, Kim SY, Cho KO. The Neuroprotective Effect of Hericium erinaceus Extracts in Mouse Hippocampus after Pilocarpine-Induced Status Epilepticus. Int J Mol Sci 2019, Vol 20, Page 859. 2019;20(4):859. doi:10.3390/IJMS20040859
Rai SN, Mishra D, Singh P, Vamanu E, Singh MP. Therapeutic applications of mushrooms and their biomolecules along with a glimpse of in silico approach in neurodegenerative diseases. Biomed Pharmacother. 2021;137:111377. doi:10.1016/J.BIOPHA.2021.111377
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Copyright (c) 2022 Tomasz Skubel, Julia Budzyńska, Jakub Czarnota, Michał Dobrzyński, Natalia Rybak, Iga Dudek
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