COVID-19 pandemic: disease impact on nervous system, cognitive functioning and mental health
DOI:
https://doi.org/10.12775/JEHS.2022.12.09.037Keywords
COVID-19, mental health, nervous system, cognition, pandemics, socializationAbstract
Introduction and purpose:
COVID-19, as an unknown disease until 2019, has posed and continues to pose a great challenge to the world of science and the people facing it. The purpose of this article is to present the possible consequences of experiencing COVID-19 disease and the pandemic itself in light of mental health and the organism functioning in the cognitive area, taking into account the impact of COVID-19 on the nervous system.
State of knowledge (brief description):
Coronaviruses are enveloped, positive single-stranded large RNA viruses. COVID-19 is a disease caused by the SARS-CoV-2 virus – its first case was reported in 2019 in Wuhan, China. Human coronaviruses can exhibit neuroinvasive, neurotropic and neurovirulent, SARS-CoV-2 also. In addition to symptoms and complications in the respiratory system, symptoms and complications are also encountered in the nervous system area; cognitive functioning may also be impaired. The pandemic as a phenomenon in itself and the outbreak of COVID-19 can carry very serious consequences from the mental health field. Among these are the problem of social isolation and its consequences or the impact of the disease and pandemic on well-being. Unfortunately, the time that has elapsed since the first cases of the disease and the amount of research does not allow a clear determination of the complications and consequences of the pandemic, but certain trends and phenomena are regularly studied and described.
Summary:
Existing research and the state of the art strongly underscore that COVID-19 and its pandemic could impinge on the mental health of people around the world. Changes in the nervous system and cognitive functioning are also observed as a result of contracting COVID-19. Science currently has no clear answers as to how long certain complications will persist and exactly what their genesis is – further research is recommended to explain them as precisely as possible.
References
Velavan TP, Meyer CG. The COVID‐19 epidemic. Tropical medicine & international health. 2020;25(3):278.
Singhal T. A review of coronavirus disease-2019 (COVID-19). The indian journal of pediatrics. 2020;87(4):281-6.
Graham RL, Baric RS. Recombination, reservoirs, and the modular spike: mechanisms of coronavirus cross-species transmission. Journal of virology. 2010;84(7):3134-46.
Pyrć K. Ludzkie koronawirusy. Postępy Nauk Medycznych. 2015;28(4B).
Ng LF, Hiscox JA. Coronaviruses in animals and humans. British Medical Journal Publishing Group; 2020.
Graham RL, Donaldson EF, Baric RS. A decade after SARS: strategies for controlling emerging coronaviruses. Nature Reviews Microbiology. 2013;11(12):836-48.
Middle East respiratory syndrome coronavirus (MERS-COV) [Internet]. World Health Organization. World Health Organization; 2019 [cited 2022Aug30]. Available from: https://www.who.int/health-topics/middle-east-respiratory-syndrome-coronavirus-mers#tab=tab_1
Novel coronavirus (2019-ncov): Situation report, 1 [Internet]. World Health Organization. World Health Organization; 2020 [cited 2022Aug30]. Available from: https://apps.who.int/iris/handle/10665/330760
Stoecklin SB, Rolland P, Silue Y, Mailles A, Campese C, Simondon A, et al. First cases of coronavirus disease 2019 (COVID-19) in France: surveillance, investigations and control measures, January 2020. Eurosurveillance. 2020;25(6):2000094.
Huang X, Wei F, Hu L, Wen L, Chen K. Epidemiology and clinical characteristics of COVID-19. Archives of Iranian medicine. 2020;23(4):268-71.
Coronaviruses [Internet]. National Institute of Allergy and Infectious Diseases. U.S. Department of Health and Human Services; 2021 [cited 2022Aug30]. Available from: https://www.niaid.nih.gov/diseases-conditions/coronaviruses
Tracking sars-COV-2 variants [Internet]. World Health Organization. World Health Organization; [cited 2022Aug30]. Available from: https://www.who.int/activities/tracking-SARS-CoV-2-variants/
Carlos AJ, Ha DP, Yeh D-W, Van Krieken R, Tseng C-C, Zhang P, et al. The chaperone GRP78 is a host auxiliary factor for SARS-CoV-2 and GRP78 depleting antibody blocks viral entry and infection. Journal of Biological Chemistry. 2021;296.
Cheng Q, Yang Y, Gao J. Infectivity of human coronavirus in the brain. EBioMedicine. 2020;56:102799.
Clinical characteristics of COVID-19 [Internet]. European Centre for Disease Prevention and Control. 2022 [cited 2022Aug30]. Available from: https://www.ecdc.europa.eu/en/covid-19/latest-evidence/clinical
Stokes EK, Zambrano LD, Anderson KN, Marder EP, Raz KM, El Burai Felix S, Tie Y, Fullerton KE. Coronavirus Disease 2019 Case Surveillance - United States, January 22-May 30, 2020. MMWR Morb Mortal Wkly Rep. 2020 Jun 19;69(24):759-765
Grant MC, Geoghegan L, Arbyn M, Mohammed Z, McGuinness L, Clarke EL, et al. The prevalence of symptoms in 24,410 adults infected by the novel coronavirus (SARS-CoV-2; COVID-19): A systematic review and meta-analysis of 148 studies from 9 countries. PloS one. 2020;15(6):e0234765.
Kronbichler A, Kresse D, Yoon S, Lee KH, Effenberger M, Shin JI. Asymptomatic patients as a source of COVID-19 infections: A systematic review and meta-analysis. International journal of infectious diseases. 2020;98:180-6.
Syangtan G, Bista S, Dawadi P, Rayamajhee B, Shrestha LB, Tuladhar R, et al. Asymptomatic people with SARS-CoV-2 as unseen carriers of COVID-19: A systematic review and meta-analysis. 2020.
Wei WE, Li Z, Chiew CJ, Yong SE, Toh MP, Lee VJ. Presymptomatic transmission of SARS-CoV-2. Morbidity and Mortality Weekly Report. 2020;69(14):411.
Symptoms of COVID-19 [Internet]. Centers for Disease Control and Prevention. Centers for Disease Control and Prevention; [cited 2022Aug30]. Available from: https://www.cdc.gov/coronavirus/2019-ncov/symptoms-testing/symptoms.html
Dymecka J. Psychosocial effects of the COVID-19 pandemic. Neuropsychiatria i Neuropsychologia/Neuropsychiatry and Neuropsychology. 2021;16(1):1-10. doi: 10.5114/nan.2021.108030.
Coronavirus disease (covid-19) situation reports [Internet]. World Health Organization. World Health Organization; [cited 2022Aug30]. Available from: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports
Ye Q, Wang B, Mao J, Fu J, Shang S, Shu Q, et al. Epidemiological analysis of COVID‐19 and practical experience from China. Journal of medical virology. 2020;92(7):755-69.
Arbour N, Day R, Newcombe J, Talbot PJ. Neuroinvasion by human respiratory coronaviruses. Journal of virology. 2000;74(19):8913-21.
Giraudon P, Bernard A. Inflammation in neuroviral diseases. Journal of neural transmission. 2010;117(8):899-906.
Wei L, Wang Z, Huang Y, Schwarz G, Wheelock V. COVID-19: Neuro-invasiveness, neurotropism and neurovirulence. Journal of Neurology and Experimental Neuroscience. 2020;6(S1):S24-S31.
Lima M, Siokas V, Aloizou A-M, Liampas I, Mentis A-FA, Tsouris Z, et al. Unraveling the possible routes of SARS-COV-2 invasion into the central nervous system. Current treatment options in neurology. 2020;22(11):1-15.
Solomon IH, Normandin E, Bhattacharyya S, Mukerji SS, Keller K, Ali AS, et al. Neuropathological features of Covid-19. New England Journal of Medicine. 2020;383(10):989-92.
Spudich S, Nath A. Nervous system consequences of COVID-19. Science. 2022;375(6578):267-9.
Bergmann CC, Lane TE, Stohlman SA. Coronavirus infection of the central nervous system: host–virus stand-off. Nature Reviews Microbiology. 2006;4(2):121-32.
Matschke J, Lütgehetmann M, Hagel C, Sperhake JP, Schröder AS, Edler C, et al. Neuropathology of patients with COVID-19 in Germany: a post-mortem case series. The Lancet Neurology. 2020;19(11):919-29.
Iadecola C, Anrather J, Kamel H. Effects of COVID-19 on the nervous system. Cell. 2020;183(1):16-27. e1.
Song E, Zhang C, Israelow B, Lu-Culligan A, Prado AV, Skriabine S, et al. Neuroinvasion of SARS-CoV-2 in human and mouse brain. Journal of Experimental Medicine. 2021;218(3).
Baig AM, Khaleeq A, Ali U, Syeda H. Evidence of the COVID-19 virus targeting the CNS: tissue distribution, host–virus interaction, and proposed neurotropic mechanisms. ACS chemical neuroscience. 2020;11(7):995-8.
Pyne JD, Brickman AM. The Impact of the COVID-19 Pandemic on Dementia Risk: Potential Pathways to Cognitive Decline. Neurodegenerative Diseases. 2021;21(1-2):1-23.
Huang YH, Jiang D, Huang JT. SARS-CoV-2 detected in cerebrospinal fluid by PCR in a case of COVID-19 encephalitis. Brain, behavior, and immunity. 2020;87:149.
Moriguchi T, Harii N, Goto J, Harada D, Sugawara H, Takamino J, et al. A first case of meningitis/encephalitis associated with SARS-Coronavirus-2. International journal of infectious diseases. 2020;94:55-8.
Cascella M, De Blasio E. Features and Management of Acute and Chronic Neuro-Covid: Springer; 2022.
Mahmudpour M, Roozbeh J, Keshavarz M, Farrokhi S, Nabipour I. COVID-19 cytokine storm: The anger of inflammation. Cytokine. 2020;133:155151.
Williamson EJ, Walker AJ, Bhaskaran K, Bacon S, Bates C, Morton CE, et al. Factors associated with COVID-19-related death using OpenSAFELY. Nature. 2020;584(7821):430-6.
Chou SH-Y, Beghi E, Helbok R, Moro E, Sampson J, Altamirano V, et al. Global incidence of neurological manifestations among patients hospitalized with COVID-19 - A report for the GCS-NeuroCOVID consortium and the ENERGY consortium. JAMA network open. 2021;4(5):e2112131-e.
Kacem I, Gharbi A, Harizi C, Souissi E, Safer M, Nasri A, et al. Characteristics, onset, and evolution of neurological symptoms in patients with COVID-19. Neurological Sciences. 2021;42(1):39-46.
Helms J, Kremer S, Merdji H, Clere-Jehl R, Schenck M, Kummerlen C, et al. Neurologic features in severe SARS-CoV-2 infection. New England Journal of Medicine. 2020;382(23):2268-70.
Asadi-Pooya AA, Simani L, Shahisavandi M, Barzegar Z. COVID-19, de novo seizures, and epilepsy: a systematic review. Neurological Sciences. 2021;42(2):415-31.
Khedr EM, Shoyb A, Mohammaden M, Saber M. Acute symptomatic seizures and COVID-19: Hospital-based study. Epilepsy Research. 2021;174:106650.
Garg RK, Paliwal VK, Gupta A. Encephalopathy in patients with COVID‐19: a review. Journal of Medical Virology. 2021;93(1):206-22.
Bridwell R, Long B, Gottlieb M. Neurologic complications of COVID-19. The American journal of emergency medicine. 2020;38(7):1549. e3-. e7.
Jiang F, Yang W-L, Wang J-W, Zhu Z, Luo C, Arendt-Nielsen L, et al. Pain during and after coronavirus disease 2019: Chinese perspectives. Pain Reports. 2021;6(1).
Vittori A, Lerman J, Cascella M, Gomez-Morad AD, Marchetti G, Marinangeli F, et al. Coronavirus Disease 2019 Pandemic Acute Respiratory Distress Syndrome Survivors: Pain After the Storm? Anesthesia and analgesia. 2020.
Finsterer J, Scorza FA. Guillain-Barre syndrome in 220 patients with COVID-19. The Egyptian journal of neurology, psychiatry and neurosurgery. 2021;57(1):1-7.
Giacomelli A, Pezzati L, Conti F, Bernacchia D, Siano M, Oreni L, et al. Self-reported olfactory and taste disorders in patients with severe acute respiratory coronavirus 2 infection: a cross-sectional study. Clinical infectious diseases. 2020;71(15):889-90.
Nepal G, Rehrig JH, Shrestha GS, Shing YK, Yadav JK, Ojha R, et al. Neurological manifestations of COVID-19: a systematic review. Critical Care. 2020;24(1):421.
Overview: Covid-19 rapid guideline: Managing the long-term effects of covid-19: Guidance [Internet]. NICE. 2020 [cited 2022Aug30]. Available from: https://www.nice.org.uk/guidance/ng188
Asadi‐Pooya AA, Akbari A, Emami A, Lotfi M, Rostamihosseinkhani M, Nemati H, et al. Long COVID syndrome‐associated brain fog. Journal of medical virology. 2022;94(3):979-84.
Hugon J, Msika E-F, Queneau M, Farid K, Paquet C. Long COVID: cognitive complaints (brain fog) and dysfunction of the cingulate cortex. Journal of Neurology. 2022;269(1):44-6.
Delgado-Alonso C, Valles-Salgado M, Delgado-Álvarez A, Yus M, Gómez-Ruiz N, Jorquera M, et al. Cognitive dysfunction associated with COVID-19: A comprehensive neuropsychological study. Journal of Psychiatric Research. 2022;150:40-6.
Vanderlind WM, Rabinovitz BB, Miao IY, Oberlin LE, Bueno-Castellano C, Fridman C, et al. A systematic review of neuropsychological and psychiatric sequalae of COVID-19: implications for treatment. Current opinion in psychiatry. 2021;34(4):420.
Kashani KB, editor Hypoxia in COVID-19: sign of severity or cause for poor outcomes. Mayo Clinic Proceedings; 2020: Elsevier.
Spence JD, De Freitas GR, Pettigrew LC, Ay H, Liebeskind DS, Kase CS, et al. Mechanisms of stroke in COVID-19. Cerebrovascular Diseases. 2020;49(4):451-8.
Magalhaes RC, Pimenta LP, Barbosa IG, Moreira JM, de Barros JL, Teixeira AL, et al. Inflammatory molecules and neurotrophic factors as biomarkers of neuropsychomotor development in preterm neonates: a systematic review. International Journal of Developmental Neuroscience. 2018;65:29-37.
Koralnik IJ, Tyler KL. COVID‐19: a global threat to the nervous system. Annals of neurology. 2020;88(1):1-11.
Girard TD, Thompson JL, Pandharipande PP, Brummel NE, Jackson JC, Patel MB, et al. Clinical phenotypes of delirium during critical illness and severity of subsequent long-term cognitive impairment: a prospective cohort study. The Lancet Respiratory Medicine. 2018;6(3):213-22.
Hopkins RO, Jackson JC. Long-term neurocognitive function after critical illness. Chest. 2006;130(3):869-78.
Han RH, Schmidt MN, Waits WM, Bell AK, Miller TL. Planning for mental health needs during COVID-19. Current psychiatry reports. 2020;22(12):1-10.
Aknin LB, De Neve J-E, Dunn EW, Fancourt DE, Goldberg E, Helliwell JF, et al. Mental health during the first year of the COVID-19 pandemic: A review and recommendations for moving forward. Perspectives on psychological science. 2022;17(4):915-36.
Clair R, Gordon M, Kroon M, Reilly C. The effects of social isolation on well-being and life satisfaction during pandemic. Humanities and Social Sciences Communications. 2021;8(1):1-6.
Nicholson NR. A review of social isolation: an important but underassessed condition in older adults. The journal of primary prevention. 2012;33(2):137-52.
Smith BJ, Lim MH. How the COVID-19 pandemic is focusing attention on loneliness and social isolation. Public Health Res Pract. 2020;30(2):3022008.
Umberson D, Karas Montez J. Social relationships and health: A flashpoint for health policy. Journal of health and social behavior. 2010;51(1):S54-S66.
Zavaleta D, Samuel K, Mills CT. Measures of social isolation. Social Indicators Research. 2017;131(1):367-91.
Hughes ME, Waite LJ, Hawkley LC, Cacioppo JT. A short scale for measuring loneliness in large surveys: Results from two population-based studies. Research on aging. 2004;26(6):655-72.
Nyqvist F, Victor CR, Forsman AK, Cattan M. The association between social capital and loneliness in different age groups: a population-based study in Western Finland. BMC public health. 2016;16(1):1-8.
Cacioppo JT, Cacioppo S. Social relationships and health: The toxic effects of perceived social isolation. Social and personality psychology compass. 2014;8(2):58-72.
Courtin E, Knapp M. Social isolation, loneliness and health in old age: a scoping review. Health & social care in the community. 2017;25(3):799-812.
Dahlberg L, McKee KJ. Social exclusion and well-being among older adults in rural and urban areas. Archives of gerontology and geriatrics. 2018;79:176-84.
Harasemiw O, Newall N, Mackenzie CS, Shooshtari S, Menec V. Is the association between social network types, depressive symptoms and life satisfaction mediated by the perceived availability of social support? A cross-sectional analysis using the Canadian Longitudinal Study on Aging. Aging & mental health. 2019;23(10):1413-22.
Mróz J, Kosowski P. Ocena komunikacji a poczucie samotności i satysfakcji z życia w czasie pandemii. Kwartalnik Naukowy Fides et Ratio. 2020;42(2):214-26. doi: 10.34766/fetr.v42i2.284.
Brooks SK, Webster RK, Smith LE, Woodland L, Wessely S, Greenberg N, et al. The psychological impact of quarantine and how to reduce it: rapid review of the evidence. The lancet. 2020;395(10227):912-20.
Aboagye E, Yawson JA, Appiah KN. COVID-19 and E-learning: The challenges of students in tertiary institutions. Social Education Research. 2021:1-8.
Gherheș V, Stoian CE, Fărcașiu MA, Stanici M. E-learning vs. face-to-face learning: Analyzing students’ preferences and behaviors. Sustainability. 2021;13(8):4381.
Rutkowska A, Cieślik B, Tomaszczyk A, Szczepańska-Gieracha J. Mental Health Conditions Among E-Learning Students During the COVID-19 Pandemic. Frontiers in Public Health. 2022;10.
Adnan M, Anwar K. Online Learning amid the COVID-19 Pandemic: Students' Perspectives. Online Submission. 2020;2(1):45-51.
Wilczewski M, Gorbaniuk O, Giuri P. The psychological and academic effects of studying from the home and host country during the COVID-19 pandemic. Frontiers in Psychology. 2021;12:644096.
Greenberg N, Weston D, Hall C, Caulfield T, Williamson V, Fong K. Mental health of staff working in intensive care during Covid-19. Occupational Medicine. 2021;71(2):62-7.
Greenberg N, Tracy D. What healthcare leaders need to do to protect the psychological well-being of frontline staff in the COVID-19 pandemic. Bmj Leader. 2020.
Williamson V, Greenberg N, Bowden G, Rothenfluh D, Nnadi C, Reynolds J. The mental health impact of providing spine care during COVID-19. The Spine Journal. 2020;20(9):1363-6.
Khajuria A, Tomaszewski W, Liu Z, Chen J-h, Mehdian R, Fleming S, et al. Workplace factors associated with mental health of healthcare workers during the COVID-19 pandemic: an international cross-sectional study. BMC health services research. 2021;21(1):1-11.
Cai H, Tu B, Ma J, Chen L, Fu L, Jiang Y, et al. Psychological impact and coping strategies of frontline medical staff in Hunan between January and March 2020 during the outbreak of coronavirus disease 2019 (COVID-19) in Hubei, China. Medical science monitor: international medical journal of experimental and clinical research. 2020;26:e924171-1.
Cao J, Wei J, Zhu H, Duan Y, Geng W, Hong X, et al. A study of basic needs and psychological wellbeing of medical workers in the fever clinic of a tertiary general hospital in Beijing during the COVID-19 outbreak. Psychotherapy and psychosomatics. 2020:1.
Lai J, Ma S, Wang Y, Cai Z, Hu J, Wei N, et al. Factors associated with mental health outcomes among health care workers exposed to coronavirus disease 2019. JAMA network open. 2020;3(3):e203976-e.
De Kock JH, Latham HA, Leslie SJ, Grindle M, Munoz S-A, Ellis L, et al. A rapid review of the impact of COVID-19 on the mental health of healthcare workers: implications for supporting psychological well-being. BMC public health. 2021;21(1):1-18.
Makara-Studzińska M, Załuski M, Lickiewicz J. Czy ozdrowieńcy COVID-19 to przyszli pacjenci psychiatrów i psychologów? Szybki przegląd literatury naukowej. Psychiatria. 2021;18(2):140-51.
Sinanović O, Muftić M, Sinanović S. COVID-19 pandemia: neuropsychiatric comorbidity and consequences. Psychiatria Danubina. 2020;32(2):236-44.
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