Long-term results of the enzyme glutation system activity in experimental ovarian cancer
DOI:
https://doi.org/10.12775/JEHS.2022.12.02.035Keywords
ascitic ovarian tumor, glutathione system, reductase, peroxidase, cancerogenesisAbstract
The article presents the experimental results of the investigation the glutathione system activity (glutathione peroxidase and glutathione reductase) in rats simulated ovarian ascites tumor. In the experimental carcinogenesis of the ovaries, the activity of glutathione reductase and glutathione peroxidase was inhibited at all intervals of the study during long-term observation. After the presence of carcinogenesis in the body, the number of reactions that do not lead to complete utilization of metabolites. Glutathione reductase activity increases between 4 and 6 months. And the activation of glutathione peroxidase for the entire period only decreases. The experiment showed that gammaglobulin with long-term treatment can increase the activity of the glutathione system.
References
Cytokines as Prognostic Biomarkers of Epithelial Ovarian Cancer (EOC): A Systematic Review and Meta-Analysis / M. N. Fahmi, H. Pradjatmo, I. Astuti, R. D. Nindrea. Asian Pacific Journal of Cancer Prevention. 2021. Vol. 22 (2). P. 315-323. doi: 10.31557/APJCP.2021.22.2.315
Development and validation a simple model for identify malignant ascites / Y.-Y. Guo, X.-L. Peng, N. Zhan et al. International Journal of Medical Sciences. 2021. Vol. 18 (9). P. 1966-1974. doi: 10.7150/ijms.53743.
Diagnostic efficacy of ascites cell block for ovarian clear cell carcinoma / H. Iwahashi, M. Miyamoto, S. Minabe et al. Diagnostic Cytopathology. 2021. Vol. 49 (6). P. 735-742. doi.org/10.1002/dc.24734
Kipps E., Tan D. S. P., Kaye S. B. Meeting the challenge of ascites in ovarian cancer: new avenues for therapy and research. Nature Reviews Cancer. 2013. Vol. 13 (4). P. 273-282. doi: 10.1038/nrc3432.
Ovarian Cancer Statistics / L. A. Torre, B. Trabert, C. E. De Santis et al. Cancer J. Clin. 2018. Vol. 68. P. 284–296. doi: 10.3322/caac.21456.
Ovarian Cancer-Associated Mesothelial Cells: Transdifferentiation to Minions of Cancer and Orchestrate Developing Peritoneal Dissemination / K. Mogi, M. Yoshihara, S. Iyoshi et al. Cancers. 2021. Vol. 13 (6). P. 1362. doi.org/10.3390/cancers13061352.
Relationship between ascites volume and clinical outcomes in epithelial ovarian cancer / Q. Quan, S. Zhou, Y. Lio et al. The Journal of Obstetrics and Gynaecology Research. 2021. Vol. 47 (4). P. 1527-1535. doi.org/10.1111/jog.14682
The untapped potential of ascites in ovarian cancer research and treatment / C. E. Ford, B. Werner, N. F. Hacker, K. Warton. British Journal of Cancer. 2020. Vol. 123 (1). P. 9-16.
Understanding the effect of mechanical forces on ovarian cancer progression / A. Martinez, M. Buckley, C. B. Scalise et al. Gynecologic Oncology. 2021. Vol. 162 (1). P. 154-162. doi.org/10.1016/j.ygyno.2021.04.003.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 L. Yershova, R. Yeromenko, I. Savytskyi, T. Alexandryna, L. Sarakhan
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 176
Number of citations: 0
