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Journal of Education, Health and Sport

Investigation of amino acids’ levels in the vitreous body of experimental animals in regmatogenic retinal detachment
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  • Investigation of amino acids’ levels in the vitreous body of experimental animals in regmatogenic retinal detachment
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  3. Vol. 11 No. 11 (2021) /
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Investigation of amino acids’ levels in the vitreous body of experimental animals in regmatogenic retinal detachment

Authors

  • H. Levytska International European University
  • I. Levytskyi International European University
  • I. Savytskyi International European University
  • L. Zaiats Ivano-Frankivsk National Medical University
  • L. Sarakhan Odessa National Medical University

DOI:

https://doi.org/10.12775/JEHS.2021.11.11.039

Keywords

rhegmatogenous retinal detachment, amino acids, vitreous body

Abstract

The article presents the results of studying the levels of amino acids in the vitreous body of rats with rhegmatogenous retinal detachment at different stages of modeling the pathology (on the 3rd, 5th and 7th day). In animals with modeling RRD, was observed a significant increase in the level of alanine, aspartate, glycine, glutamic acid compared with rats of conditionally intact group; maximum changes in indicators were observed on the 7th day of the study. The obtained data are explained by significant neurochemical changes of the glutamatergic system of the neural retina, which cause excitotoxicity (as a result of massive release of neuronal glutamate) and structural changes. In the study of the level of valine, histidine, tyrosine, phenylalanine and methionine, it was found that these amino acids are not involved in the pathogenesis of RRD, so their level does not change. The obtained experimental data deepen the existing pathophysiological data on the pathogenetic links of rhegmatogenous retinal detachment in the early stages of its progression, which is important for practical ophthalmology to develop effective pharmacotherapy of this disease.

References

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Methods of statistical processing of medical data: method. reccom. / А. G. Kochetov, O. V. Liang, I. V. Zhirov et al. М.: RKNPK, 2012. 42 p. (In Russian)

Pasechnikova N. V., Levitskaya G. V. Amino acid profile of vitreous and vitreal contents in patients with rhegmatogenous detachment with different clinical characteristics. Oftalmologiya. 2014. Vol. 2 (15). P. 45–55. (In Russian)

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Drug Delivery to the Posterior Segment of the Eye: Biopharmaceutic and Pharmacokinetic Considerations / R. Varela-Fernandez, V. Diaz-Tome, A. Luaces-Rodriguez et al. Pharmaceutics. 2020. Vol. 12 (269). doi:10.3390/pharmaceutics 12030269.

https://zakon.rada.gov.ua/laws/show/3447-15

Increased glutamate levels in the vitreous of patients with retinal detachment / R. M. Diederen, E. C. La Heij, N. E. Deutz et al. Exp. Eye Res. 2006. Vol. 83 (1). P. 45–50.

Memantine is neuroprotective in a rat model of pressure-induced retinal ischemia / W. A. Lagrèze, R. Knörle, M. Bach et al. Invest. Ophthalmol. Vis. Sci. 1998. Vol. 39. P. 1063–1066.

Relocalization of apoptosis-inducing factor in photoreceptor apoptosis induced by retinal detachment in vivo / T Hisatomi et al. The American Journal of Pathology. 2001. № 4 (158). Р. 1271–1278.

Simvastatin, edaravone and dexamethasone protect against kainite-induced brain endothelial cell damage / L. Barna, F. R. Walter, M. A. Deli et al. Fluids and Barriers of the CNS. 2020. Vol. 5 (17). doi: https://doi.org/10.1186/s12987-019-0166-1

Vitreous antioxidants, degeneration, and vitreo-rethinopathy: exploring the links / E. Ankamah, J. Sebag, E. Ng, J. M. Nolan. Antioxidants (Basel). 2020. Vol. 9 (1). doi: 10.3390/antiox9010007

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Published

2021-11-30

How to Cite

1.
LEVYTSKA, H., LEVYTSKYI, I., SAVYTSKYI, I., ZAIATS, L. and SARAKHAN, L. Investigation of amino acids’ levels in the vitreous body of experimental animals in regmatogenic retinal detachment. Journal of Education, Health and Sport. Online. 30 November 2021. Vol. 11, no. 11, pp. 414-422. [Accessed 18 May 2025]. DOI 10.12775/JEHS.2021.11.11.039.
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Issue

Vol. 11 No. 11 (2021)

Section

Research Articles

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Copyright (c) 2021 H. Levytska, I. Levytskyi, I. Savytskyi, L. Zaiats, L. Sarakhan

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

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