The role of magnesium deficiency in the pathogenesis of hypertension and the influence of magnesium supplementation on blood pressure – literature review
DOI:
https://doi.org/10.12775/JEHS.2022.12.09.010Keywords
magnesium, hypertension, deficiency, supplementationAbstract
Magnesium is a macronutrient that is very important for the proper functioning of the human body. Deficiency of this element is crucial in the development of many disorders in the proper functioning of many organ systems. The optimal level of magnesium has a significant influence on the functioning of the cardiovascular system, among others. Although the factors showing the mechanism of lowering blood pressure by magnesium ions are not fully understood, the influence of the correct concentration of magnesium in the human body on cardiovascular protection is beyond doubt. Magnesium supplementation produces positive effects in the functioning of blood vessels and in maintaining blood pressure within the normal range. In our article, we focused on the role of magnesium in maintaining normal blood pressure at the molecular, cellular and tissue levels, as well as on the impact of magnesium supplementation on reducing blood pressure.
References
Kostov K, Halacheva L. Role of Magnesium Deficiency in Promoting Atherosclerosis, Endothelial Dysfunction, and Arterial Stiffening as Risk Factors for Hypertension. Int J Mol Sci. 2018 Jun 11;19(6):1724. doi: 10.3390/ijms19061724. PMID: 29891771; PMCID: PMC6032400.
Dominguez L, Veronese N, Barbagallo M. Magnesium and Hypertension in Old Age. Nutrients. 2020 Dec 31;13(1):139. doi: 10.3390/nu13010139. PMID: 33396570; PMCID: PMC7823889.
Patni N, Fatima M, Lamis A, Siddiqui SW, Ashok T, Muhammad A. Magnesium and Hypertension: Decoding Novel Anti-hypertensives. Cureus. 2022 Jun 10;14(6):e25839. doi: 10.7759/cureus.25839. PMID: 35836446; PMCID: PMC9273175.
Dominguez LJ, Gea A, Ruiz-Estigarribia L, Sayón-Orea C, Fresán U, Barbagallo M, Ruiz-Canela M, Martínez-González MA. Low Dietary Magnesium and Overweight/Obesity in a Mediterranean Population: A Detrimental Synergy for the Development of Hypertension. The SUN Project. Nutrients. 2020 Dec 31;13(1):125. doi: 10.3390/nu13010125. PMID: 33396318; PMCID: PMC7824180.
Maier JA, Bernardini D, Rayssiguier Y, Mazur A. High concentrations of magnesium modulate vascular endothelial cell behaviour in vitro. Biochim Biophys Acta. 2004 May 24;1689(1):6-12. doi: 10.1016/j.bbadis.2004.02.004. PMID: 15158908.
Carbone F, Elia E, Casula M, Bonaventura A, Liberale L, Bertolotto M, Artom N, Minetti S, Dallegri F, Contini P, Verzola D, Pontremoli R, Viazzi F, Viviani GL, Bertolini S, Pende A, Pisciotta L, Montecucco F. Baseline hs-CRP predicts hypertension remission in metabolic syndrome. Eur J Clin Invest. 2019 Aug;49(8):e13128. doi: 10.1111/eci.13128. Epub 2019 Jun 3. PMID: 31091356.
Rude R.K., Shils M.E. Magnesium. In: Shils M.E., Shike M., Ross A.C., Caballero B., Cousins R.J., eds. Modern nutrition in health and disease. Baltimore: Lippincott Williams & Wilkins; 2006. 10th ed223-247
Hashizume N, Mori M: An analysis of hypermagnesemia and hypomagnesemia. Jpn J Med, 1990, 29, 368-372.
Choi MK, Bae YJ. Association of Magnesium Intake with High Blood Pressure in Korean Adults: Korea National Health and Nutrition Examination Survey 2007-2009. PLoS One. 2015 Jun 15;10(6):e0130405. doi: 10.1371/journal.pone.0130405. PMID: 26075385; PMCID: PMC4468246.
Gröber U, Schmidt J, Kisters K. Magnesium in Prevention and Therapy. Nutrients. 2015 Sep 23;7(9):8199-8226. doi: 10.3390/nu7095388. PMID: 26404370; PMCID: PMC4586582.
de Baaij JH, Hoenderop JG, Bindels RJ. Regulation of magnesium balance: lessons learned from human genetic disease. Clin Kidney J. 2012 Feb;5(Suppl 1):i15-i24. doi: 10.1093/ndtplus/sfr164. PMID: 26069817; PMCID: PMC4455826.
Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet. 2005 Jan 15-21;365(9455):217-23. doi: 10.1016/S0140-6736(05)17741-1. PMID: 15652604.
Elliott WJ, Czarny HR. Farmakologia kliniczna i terapia nadciśnienia, Podręcznik nadciśnienia. Tom. 25. Edynburg; Nowy Jork: Elsevier; 2008. Podstawa dowodowa leczenia nadciśnienia tętniczego; s. 413–452.
Ismail A.A., Ismail N.A. Magnesium: A mineral essential for health yet generally underestimated or even ignored. J. Nutr. Food Sci. 2016;6:2. doi: 10.4172/2155-9600.1000523.
Giles TD, Berk BC, Black HR, Cohn JN, Kostis JB, Izzo JL Jr, Weber MA. Expanding the definition and classification of hypertension. J Clin Hypertens (Greenwich). 2005 Sep;7(9):505-12. doi: 10.1111/j.1524-6175.2005.04769.x. PMID: 16227769; PMCID: PMC8109641.
Qu X, Jin F, Hao Y, Li H, Tang T, Wang H, Yan W, Dai K. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies. PLoS One. 2013;8(3):e57720. doi: 10.1371/journal.pone.0057720. Epub 2013 Mar 8. PMID: 23520480; PMCID: PMC3592895.
Kass L., Sullivan K.R. Low Dietary Magnesium Intake and Hypertension. World J. Cardiovasc. Dis. 2016;6:447. doi: 10.4236/wjcd.2016.612048.
Altura B.M., Li W., Zhang A., Zheng T., Shah N.C. Sudden cardiac death in infants, children and young adults: Possible roles of dietary magnesium intake and generation of platelet-activating factor in coronary arteries. J. Heart Health. 2016;2:1–5.
Appel LJ, Moore TJ, Obarzanek E, Vollmer WM, Svetkey LP, Sacks FM, Bray GA, Vogt TM, Cutler JA, Windhauser MM, Lin PH, Karanja N. A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. N Engl J Med. 1997 Apr 17;336(16):1117-24. doi: 10.1056/NEJM199704173361601. PMID: 9099655.
Touyz RM, Yao G. Modulation of vascular smooth muscle cell growth by magnesium-role of mitogen-activated protein kinases. J Cell Physiol. 2003 Dec;197(3):326-35. doi: 10.1002/jcp.10393. PMID: 14566962.
Belin RJ, He K. Magnesium physiology and pathogenic mechanisms that contribute to the development of the metabolic syndrome. Magnes Res. 2007 Jun;20(2):107-29. PMID: 18062585.
Houston M. The role of magnesium in hypertension and cardiovascular disease. J Clin Hypertens (Greenwich). 2011 Nov;13(11):843-7. doi: 10.1111/j.1751-7176.2011.00538.x. Epub 2011 Sep 26. PMID: 22051430; PMCID: PMC8108907.
Baldoli E, Castiglioni S, Maier JA. Regulation and function of TRPM7 in human endothelial cells: TRPM7 as a potential novel regulator of endothelial function. PLoS One. 2013;8(3):e59891. doi: 10.1371/journal.pone.0059891. Epub 2013 Mar 22. PMID: 23533657; PMCID: PMC3606311.
Paravicini TM, Chubanov V, Gudermann T. TRPM7: a unique channel involved in magnesium homeostasis. Int J Biochem Cell Biol. 2012 Aug;44(8):1381-4. doi: 10.1016/j.biocel.2012.05.010. Epub 2012 May 24. PMID: 22634382.
Touyz RM. Role of magnesium in the pathogenesis of hypertension. Mol Aspects Med. 2003 Feb-Jun;24(1-3):107-36. doi: 10.1016/s0098-2997(02)00094-8. PMID: 12537992.
Baldoli E, Maier JA. Silencing TRPM7 mimics the effects of magnesium deficiency in human microvascular endothelial cells. Angiogenesis. 2012 Mar;15(1):47-57. doi: 10.1007/s10456-011-9242-0. Epub 2011 Dec 20. PMID: 22183257.
Di A, Malik AB. TRP channels and the control of vascular function. Curr Opin Pharmacol. 2010 Apr;10(2):127-32. doi: 10.1016/j.coph.2009.11.010. Epub 2010 Jan 7. PMID: 20060363.
Dolinsky BM, Ippolito DL, Tinnemore D, Stallings JD, Zelig CM, Napolitano PG. The effect of magnesium sulfate on the activity of matrix metalloproteinase-9 in fetal cord plasma and human umbilical vein endothelial cells. Am J Obstet Gynecol. 2010 Oct;203(4):371.e1-5. doi: 10.1016/j.ajog.2010.06.012. Epub 2010 Aug 16. PMID: 20719294.
Ritchie G, Kerstan D, Dai LJ, Kang HS, Canaff L, Hendy GN, Quamme GA. 1,25(OH)(2)D(3) stimulates Mg2+ uptake into MDCT cells: modulation by extracellular Ca2+ and Mg2+. Am J Physiol Renal Physiol. 2001 May;280(5):F868-78. doi: 10.1152/ajprenal.2001.280.5.F868. PMID: 11292630.
Hagström E, Ahlström T, Ärnlöv J, Larsson A, Melhus H, Hellman P, Lind L. Parathyroid hormone and calcium are independently associated with subclinical vascular disease in a community-based cohort. Atherosclerosis. 2015 Feb;238(2):420-6. doi: 10.1016/j.atherosclerosis.2014.12.027. Epub 2014 Dec 20. PMID: 25562577.
Louvet L, Bazin D, Büchel J, Steppan S, Passlick-Deetjen J, Massy ZA. Characterisation of calcium phosphate crystals on calcified human aortic vascular smooth muscle cells and potential role of magnesium. PLoS One. 2015 Jan 21;10(1):e0115342. doi: 10.1371/journal.pone.0115342. PMID: 25607936; PMCID: PMC4301909.
Zhang X, Li Y, Del Gobbo LC, Rosanoff A, Wang J, Zhang W, Song Y. Effects of Magnesium Supplementation on Blood Pressure: A Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials. Hypertension. 2016 Aug;68(2):324-33. doi: 10.1161/HYPERTENSIONAHA.116.07664. Epub 2016 Jul 11. PMID: 27402922.
Whang R, Chrysant S, Dillard B, Smith W, Fryer A. Hypomagnesemia and hypokalemia in 1,000 treated ambulatory hypertensive patients. J Am Coll Nutr. 1982;1(4):317-22. doi: 10.1080/07315724.1982.10719001. PMID: 7185863.
Kolte D, Vijayaraghavan K, Khera S, Sica DA, Frishman WH. Role of magnesium in cardiovascular diseases. Cardiol Rev. 2014 Jul-Aug;22(4):182-92. doi: 10.1097/CRD.0000000000000003. PMID: 24896250.
Cunha AR, Umbelino B, Correia ML, Neves MF. Magnesium and vascular changes in hypertension. Int J Hypertens. 2012;2012:754250. doi: 10.1155/2012/754250. Epub 2012 Feb 29. PMID: 22518291; PMCID: PMC3299255.
Sontia B, Touyz RM. Role of magnesium in hypertension. Arch Biochem Biophys. 2007 Feb 1;458(1):33-9. doi: 10.1016/j.abb.2006.05.005. Epub 2006 May 24. PMID: 16762312.
Laurant P, Dalle M, Berthelot A, Rayssiguier Y. Time-course of the change in blood pressure level in magnesium-deficient Wistar rats. Br J Nutr. 1999 Sep;82(3):243-51. PMID: 10655971.
James MF, Beer RE, Esser JD. Intravenous magnesium sulfate inhibits catecholamine release associated with tracheal intubation. Anesth Analg. 1989 Jun;68(6):772-6. PMID: 2735543.
Douglas WW, Rubin RP. The mechanism of catecholamine release from the adrenal medulla and the role of calcium in stimulus-secretion coupling. J Physiol. 1963 Jul;167(2):288-310. doi: 10.1113/jphysiol.1963.sp007150. PMID: 16992152; PMCID: PMC1359395.
Ma J, Folsom AR, Melnick SL, Eckfeldt JH, Sharrett AR, Nabulsi AA, Hutchinson RG, Metcalf PA. Associations of serum and dietary magnesium with cardiovascular disease, hypertension, diabetes, insulin, and carotid arterial wall thickness: the ARIC study. Atherosclerosis Risk in Communities
Torshin IIu, Gromova OA, Gusev EI. Mechanisms of antistress and antidepressive effects of magnesium and pyridoxine. Zh Nevrol Psikhiatr Im S S Korsakova. 2009;109(11):107-11. Russian. PMID: 20120072.
Kim DJ, Xun P, Liu K, Loria C, Yokota K, Jacobs DR Jr, He K. Magnesium intake in relation to systemic inflammation, insulin resistance, and the incidence of diabetes. Diabetes Care. 2010 Dec;33(12):2604-10. doi: 10.2337/dc10-0994. Epub 2010 Aug 31. PMID: 20807870; PMCID: PMC2992198.
Heagerty AM, Aalkjaer C, Bund SJ, Korsgaard N, Mulvany MJ. Small artery structure in hypertension. Dual processes of remodeling and growth. Hypertension. 1993 Apr;21(4):391-7. doi: 10.1161/01.hyp.21.4.391. PMID: 8458640.
Pochwat B, Szewczyk B, Sowa-Kucma M, Siwek A, Doboszewska U, Piekoszewski W, Gruca P, Papp M, Nowak G. Antidepressant-like activity of magnesium in the chronic mild stress model in rats: alterations in the NMDA receptor subunits. Int J Neuropsychopharmacol. 2014 Mar;17(3):393-405. doi: 10.1017/S1461145713001089. Epub 2013 Sep 26. PMID: 24067405.
Agyei B, Nicolaou M, Boateng L, Dijkshoorn H, van den Born BJ, Agyemang C. Relationship between psychosocial stress and hypertension among Ghanaians in Amsterdam, the Netherlands--the GHAIA study. BMC Public Health. 2014 Jul 7;14:692. doi: 10.1186/1471-2458-14-692. PMID: 25001592; PMCID: PMC4099212.
Torshin I.Y., Gromova O.A. Connective tissue dysplasia, cell biology and molecular mechanisms of magnesium exposure. RMZh. 2008;16:230–238.
Hruby A, O'Donnell CJ, Jacques PF, Meigs JB, Hoffmann U, McKeown NM. Magnesium intake is inversely associated with coronary artery calcification: the Framingham Heart Study. JACC Cardiovasc Imaging. 2014 Jan;7(1):59-69. doi: 10.1016/j.jcmg.2013.10.006. Epub 2013 Nov 27. PMID: 24290571; PMCID: PMC3957229.
Kalra SS, Shanahan CM. Vascular calcification and hypertension: cause and effect. Ann Med. 2012 Jun;44 Suppl 1:S85-92. doi: 10.3109/07853890.2012.660498. PMID: 22713153.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Filip Białas, Dominik Machaj, Patrycja Baciur, Katarzyna Skowrońska, Anna Chmura
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 732
Number of citations: 0