Creatine supplementation and its influence on human organism
DOI:
https://doi.org/10.12775/JEHS.2022.12.09.002Keywords
creatine, supplementation, influence, kidney, renal effectsAbstract
Background: Creatine supplementation is one of the most popular methods of improving athletic performance. In this article we reviewed its positive and negative influence on human organism.
Materials and Methods: This paper was based on medical articles collected in PubMed from 1998 to 2019. The research has been done by looking through the key words such as: “creatine”, “supplementation”, “influence”, “kidney”, “renal effects”.
Results: Creatine supplementation has no negative influence on renal function. Moreover it appears to have a positive effect on some aspects of metabolism.
Conclusions: According to the available knowledge, creatine supplementation in appropriate doses is safe.
References
Antonio J, Candow DG, Forbes SC, Gualano B, Jagim AR, Kreider RB, Rawson ES, Smith-Ryan AE, VanDusseldorp TA, Willoughby DS, Ziegenfuss TN. Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show? J Int Soc Sports Nutr. 2021 Feb 8;18(1):13. doi: 10.1186/s12970-021-00412-w. PMID: 33557850; PMCID: PMC7871530.
Vega J, Huidobro E JP. Efectos en la función renal de la suplementación de creatina con fines deportivos [Effects of creatine supplementation on renal function]. Rev Med Chil. 2019 May;147(5):628-633. Spanish. doi: 10.4067/S0034-98872019000500628. PMID: 31859895.
Hall M, Trojian TH. Creatine supplementation. Curr Sports Med Rep. 2013 Jul-Aug;12(4):240-4. doi: 10.1249/JSR.0b013e31829cdff2. PMID: 23851411.
Persky AM, Brazeau GA. Clinical pharmacology of the dietary supplement creatine monohydrate. Pharmacol. Rev. 2001; 53:161Y76
Williams MH, Branch JD. Creatine supplementation and exercise performance: an update. J. Am. Coll. Nutr. 1998; 17:2
Robinson TM, Sewell DA, Hultman E, Greenhaff PL. Role of submaximal exercise in promoting creatine and glycogen accumulation in human skeletal muscle. J. Appl. Physiol. 1999; 87:598Y604
Willis J, Jones R, Nwokolo N, Levy J. Protein and creatine supplements and misdiagnosis of kidney disease. BMJ 2010; 340: b5027.
Lugaresi R, Leme M, de Salles Painelli V, Murai IH, Roschel H, Sapienza MT, et al. Does long-term creatine supplementation impair kidney function in resistance-trained individuals consuming a high-protein diet? J Int Soc Sports Nutr 2013; 10: 26. [ Links ]
Deminice R, da Silva RP, Lamarre SG, Brown C, Furey GN, McCarter SA, Jordao AA, Kelly KB, King-Jones K, Jacobs RL, Brosnan ME, Brosnan JT (2011) Creatine supplementation prevents the accumulation of fat in the livers of rats fed a high-fat diet. J Nutr 141(10):1799–1804. doi:10.3945/jn.111.144857
de Souza E Silva A, Pertille A, Reis Barbosa CG, Aparecida de Oliveira Silva J, de Jesus DV, Ribeiro AGSV, Baganha RJ, de Oliveira JJ. Effects of Creatine Supplementation on Renal Function: A Systematic Review and Meta-Analysis. J Ren Nutr. 2019 Nov;29(6):480-489. doi: 10.1053/j.jrn.2019.05.004. Epub 2019 Jul 30. PMID: 31375416.
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Copyright (c) 2022 Wojciech Siedlecki, Klaudia Remjasz, Katarzyna Kosz, Aleksandra Kuchnicka, Julia Kuchnicka, Natalia Zarankiewicz, Martyna Zielińska, Klaudia Sapuła, Jakub Aleksandrowicz, Mateusz Fabiś
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