Ranula as an early symptom of Sjögren’s syndrome
DOI:
https://doi.org/10.12775/JEHS.2022.12.09.001Keywords
Sjogren’s syndrome, Ranula, Mucocele, early diagnosisAbstract
Introduction and purpose:
Sjögren's syndrome is an autoimmune disease affecting exocrine glands, mainly salivary glands. A ranula is a type of retention cyst associated with salivary extravasation that develops within the large salivary glands. The most common reason of developing ranula is trauma of bottom of the oral cavity. Damaging the sublingual gland, due to changes in Sjögren’s syndrome, may lead to the development of ranula. The aim of this review is to analyze the possible impact of ranulas on early diagnosis of Sjögren's syndrome.
Material and method:
This review was based on articles collected in PubMed and published in the years 2003-2021 and books from 2009 and 2018. Articles were chosen using keywords such as "Sjögren's syndrome", "ranula", “mucocele” and "early diagnosis".
Results:
Ranulas are considered to be early clinical signs of Sjögren's syndrome. Undergoing diagnostic imaging in patients with ranulas allows to diagnose Sjögren's syndrome in early stage and implement appropriate therapy.
Conclusion:
Identification of ranula should suggest implementation of diagnostics of Sjögren's syndrome using imaging methods such as magnetic resonance imaging or ultrasonography. Early diagnosis of Sjögren's syndrome is crucial to start the adequate treatment and get better results. It is recommended to include imaging tests in the diagnostic criteria of adolescent and adult SS in order to facilitate the diagnosis at an earlier stage of the disease.
References
Kawalec W, Grenda R, Kulus M, Pediatria II, Wydanie II, Warszawa, Anna Plewa, 2018, ISBN 978-83-200-5582-5
Behrbohm H, Kaschke O, Nawka T, Swift A. Ear, Nose, and Throat Diseases With Head and Neck Surgery, 3rd English edition, Stuttgart, Georg Thieme Verlag KG, 2009, ISBN 978-3-13-671203-0
Huzaifa M, Soni A. Mucocele And Ranula. 2021 Feb 13. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021
Baurmash HD. Mucoceles and ranulas. J Oral Maxillofac Surg. 2003; 61(3):369-78. DOI: 10.1053/joms.2003.50074
Carlini V, Calcaterra V, Pasqua N, Guazzotti M, Fusillo M, Pelizzo G. Plunging Ranula in Children: Case Report and Literature Review. Pediatr Rep . 2016;8:6576. DOI: 10.4081/pr.2016.6576
Mínguez-Martinez I, Bonet-Coloma C, Ata-Ali-Mahmud J, Carrillo-García C, Peñarrocha-Diago M, Peñarrocha-Diago M. Clinical characteristics, treatment, and evolution of 89 mucoceles in children. J Oral Maxillofac Surg. 2010; 68(10):2468-71. DOI: 10.1016/j.joms.2009.12.038
Wu CW, Kao YH, Chen CM, Hsu HJ, Chen CM, Huang IY. Mucoceles of the oral cavity in pediatric patients. Kaohsiung J Med Sci. 2011; 27(7):276-9. DOI: 10.1016/j.kjms.2010.09.006
Takagi Y, Hashimoto K, Katayama I, Eida S, Sumi M. Juvenile primary Sjögren's syndrome with ranula: is ranula a clinical sign that leads to early detection of Sjögren's syndrome? Oral Radiol. 2021; 37:328–335. DOI: 10.1007/s11282-020-00473-8
Means C, Mark A, Aldape MA, King E. Pediatric primary Sjögren syndrome presenting with bilateral ranulas: a case report and systematic review of the literature. Int J Pediatric Otorhinolaryngol. 2017; 101:11–19. DOI: 10.1016/j.ijporl.2017.07.019
Sato K, Yoshida Y, Sakai K, Shibui T, Hashimoto K, Baba A, et al. Sjögren’s syndrome and ranula development. Oral Dis. 2019; 25:1664–1667. DOI: 10.1111/odi.13130
Lieberman SM, Lu A, McGill MM. Oral lesions as presenting feature of childhood Sjögren syndrome. Int J Pediatr Otorhinolaryngol. 2018; 113:303–304. DOI: 10.1016/j.ijporl.2018.05.007
Pinheiro JB, Tirapelli C, Silva CHLD, Komesu MC, Petean FC, Louzada Junior P, León JE, Motta ACF. Oral Nodular Lesions in Patients with Sjögren's Syndrome: Unusual Oral Implications of a Systemic Disorder. Braz Dent J. 2017; 28:405–412. DOI: 10.1590/0103-6440201601013
Chen N, Zeng D, Su Y. Role of ranulas in early diagnosis of Sjögren’s syndrome: A case report. World J Clin Cases. 2021; 9(20):5701–5708. DOI: 10.12998/wjcc.v9.i20.5701
Tsuboi H, Hagiwara S, Asashima H, Takahashi H, Hirota T, Noma H, Umehara H, Kawakami A, Nakamura H, Sano H, Tsubota K, Ogawa Y, Takamura E, Saito I, Inoue H, Nakamura S, Moriyama M, Takeuchi T, Tanaka Y, Hirata S, Mimori T, Matsumoto I, Sumida T. Comparison of performance of the 2016 ACR-EULAR classification criteria for primary Sjögren's syndrome with other sets of criteria in Japanese patients. Ann Rheum Dis. 2017; 76:1980–1985. DOI: 10.1136/annrheumdis-2016-210758
Baldini C, Ferro F, Elefante E, Bombardieri S. Biomarkers for Sjögren's syndrome. Biomark Med. 2018; 12:275–286. DOI: 10.2217/bmm-2017-0297
Beckman KA, Luchs J, Milner MS, Ambrus JL Jr. The Potential Role for Early Biomarker Testing as Part of a Modern, Multidisciplinary Approach to Sjögren's Syndrome Diagnosis. Adv Ther. 2017; 34:799–812. DOI: 10.1007/s12325-017-0501-3
Shen L, Suresh L, Lindemann M, Xuan J, Kowal P, Malyavantham K, Ambrus JL Jr. Novel autoantibodies in Sjogren's syndrome. Clin Immunol. 2012; 145:251–255. DOI: 10.1016/j.clim.2012.09.013
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Jakub Aleksandrowicz, Martyna Zielińska, Natalia Zarankiewicz, Julia Kuchnicka, Katarzyna Kosz, Aleksandra Kuchnicka, Klaudia Sapuła, Klaudia Remjasz, Wojciech Siedlecki, Mateusz Fabiś
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 498
Number of citations: 0
