Diabetes mellitus and COVID-19: current state of knowledge
DOI:
https://doi.org/10.12775/JEHS.2022.12.08.101Keywords
covid-19, diabetes, SARS-CoV-2Abstract
Introduction:
Diabetes mellitus is a chronic metabolic disease characterized by disturbances in carbohydrate metabolism. Long-term high blood glucose levels can lead to a variety of serious complications and organ failure. Diabetic patients are particularly at risk of the severe course of COVID-19.
Objective:
The study aimed to investigate the relationship between diabetes and COVID-19. The literature available in the PubMed database was used to carry out a systematic review of the literature. The meta-analyzes from 2021 and 2022 were used for the analysis, with the inclusion of the phrases "DIABETES" and "COVID-19" in the title.
A brief description of the state of knowledge:
Diabetes does not increase the incidence of COVID-19, but the risk of severe disease is higher in patients with diabetes compared to the non-diabetic population. This is especially true of patients with uncontrolled glycaemia. SARS-CoV-2 disrupts the carbohydrate metabolism, can damage pancreatic beta cells and, in this mechanism, induce diabetes or cause the progression of pre-existing diabetes. There is an increased incidence of COVID-19 complications, including acute respiratory distress syndrome and death in patients with diabetes.
Conclusions:
Diabetic patients are at a higher risk of the severe course and rapid progression of COVID-19. Important in COVID-19 therapy is glycemic control and monitoring the percentage of glycosylated hemoglobin, CRP and D-dimers. The modification of the current treatment may be necessary. In patients who have undergone COVID-19, attention should be paid to the possibility of induction of diabetes or dysregulation of carbohydrate metabolism in patients suffering from diabetes previously.
References
Varikasuvu SR, Dutt N, Thangappazham B, Varshney S. Diabetes and COVID-19: A pooled analysis related to disease severity and mortality. Prim Care Diabetes. 2021 Feb;15(1):24-27. doi: 10.1016/j.pcd.2020.08.015. Epub 2020 Aug 29. PMID: 32891525; PMCID: PMC7456278.
Corona G, Pizzocaro A, Vena W, Rastrelli G, Semeraro F, Isidori AM, Pivonello R, Salonia A, Sforza A, Maggi M. Diabetes is most important cause for mortality in COVID-19 hospitalized patients: Systematic review and meta-analysis. Rev Endocr Metab Disord. 2021 Jun;22(2):275-296. doi: 10.1007/s11154-021-09630-8. Epub 2021 Feb 22. PMID: 33616801; PMCID: PMC7899074.
Wu ZH, Tang Y, Cheng Q. Diabetes increases the mortality of patients with COVID-19: a meta-analysis. Acta Diabetol. 2021 Feb;58(2):139-144. doi: 10.1007/s00592-020-01546-0. Epub 2020 Jun 24. PMID: 32583078; PMCID: PMC7311595.
Palaiodimos L, Chamorro-Pareja N, Karamanis D, Li W, Zavras PD, Chang KM, Mathias P, Kokkinidis DG. Diabetes is associated with increased risk for in-hospital mortality in patients with COVID-19: a systematic review and meta-analysis comprising 18,506 patients. Hormones (Athens). 2021 Jun;20(2):305-314. doi: 10.1007/s42000-020-00246-2. Epub 2020 Oct 29. PMID: 33123973; PMCID: PMC7595056.
Kaminska H, Szarpak L, Kosior D, Wieczorek W, Szarpak A, Al-Jeabory M, Gawel W, Gasecka A, Jaguszewski MJ, Jarosz-Chobot P. Impact of diabetes mellitus on in-hospital mortality in adult patients with COVID-19: a systematic review and meta-analysis. Acta Diabetol. 2021 Aug;58(8):1101-1110. doi: 10.1007/s00592-021-01701-1. Epub 2021 Mar 20. PMID: 33778910; PMCID: PMC8005367.
Mahamat-Saleh Y, Fiolet T, Rebeaud ME, Mulot M, Guihur A, El Fatouhi D, Laouali N, Peiffer-Smadja N, Aune D, Severi G. Diabetes, hypertension, body mass index, smoking and COVID-19-related mortality: a systematic review and meta-analysis of observational studies. BMJ Open. 2021 Oct 25;11(10):e052777. doi: 10.1136/bmjopen-2021-052777. PMID: 34697120; PMCID: PMC8557249.
Bradley SA, Banach M, Alvarado N, Smokovski I, Bhaskar SMM. Prevalence and impact of diabetes in hospitalized COVID-19 patients: A systematic review and meta-analysis. J Diabetes. 2022 Feb;14(2):144-157. doi: 10.1111/1753-0407.13243. Epub 2021 Dec 23. PMID: 34939735.
Pasterczyk-Bielska K, Gajda P, Dzida G. Cukrzyca w dobie COVID-19. Lekarz POZ. 2021;7(1).
Schlesinger S, Neuenschwander M, Lang A, Pafili K, Kuss O, Herder C, Roden M. Risk phenotypes of diabetes and association with COVID-19 severity and death: a living systematic review and meta-analysis. Diabetologia. 2021 Jul;64(7):1480-1491. doi: 10.1007/s00125-021-05458-8. Epub 2021 Apr 28. PMID: 33907860; PMCID: PMC8079163.
Longmore DK, Miller JE, Bekkering S, Saner C, Mifsud E, Zhu Y, Saffery R, Nichol A, Colditz G, Short KR, Burgner DP; International BMI-COVID consortium. Diabetes and Overweight/Obesity Are Independent, Nonadditive Risk Factors for In-Hospital Severity of COVID-19: An International, Multicenter Retrospective Meta-analysis. Diabetes Care. 2021 Jun;44(6):1281-1290. doi: 10.2337/dc20-2676. Epub 2021 Apr 15. PMID: 33858854; PMCID: PMC8247499.
Sathish T, Kapoor N, Cao Y, Tapp RJ, Zimmet P. Proportion of newly diagnosed diabetes in COVID-19 patients: A systematic review and meta-analysis. Diabetes Obes Metab. 2021 Mar;23(3):870-874. doi: 10.1111/dom.14269. Epub 2020 Dec 29. PMID: 33245182; PMCID: PMC7753574.
Sathish T, Cao Y. Is newly diagnosed diabetes as frequent as preexisting diabetes in COVID-19 patients? Diabetes Metab Syndr. 2021 Jan-Feb;15(1):147-148. doi: 10.1016/j.dsx.2020.12.024. Epub 2020 Dec 15. PMID: 33352453; PMCID: PMC7737525.
Debi H, Itu ZT, Amin MT, Hussain F, Hossain MS. Association of serum C-reactive protein (CRP) and D-dimer concentration on the severity of COVID-19 cases with or without diabetes: a systematic review and meta-analysis. Expert Rev Endocrinol Metab. 2022 Jan;17(1):83-93. doi: 10.1080/17446651.2022.2002146. Epub 2021 Nov 16. PMID: 34781810; PMCID: PMC8607539.
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