Humanities
Skip to main content Skip to main navigation menu Skip to site footer
  • Register
  • Login
  • Menu
  • Home
  • Current
  • Archives
  • Announcements
  • About
    • About the Journal
    • Submissions
    • Editorial Team
    • Privacy Statement
    • Contact
  • Register
  • Login

Journal of Education, Health and Sport

The complement system and its role in the treatment of ANCA-associated vasculitis
  • Home
  • /
  • The complement system and its role in the treatment of ANCA-associated vasculitis
  1. Home /
  2. Archives /
  3. Vol. 12 No. 8 (2022) /
  4. Review Articles

The complement system and its role in the treatment of ANCA-associated vasculitis

Authors

  • Natalia Rybak Independent Public Clinical Hospital No. 4 in Lublin, Jaczewskiego 8, 20-954 Lublin https://orcid.org/0000-0003-1437-7661
  • Iga Dudek 1 Military Clinical Hospital with a Polyclinic in Lublin, Al. Racławickie 23, 20-904 Lublin https://orcid.org/0000-0002-8101-074X
  • Jakub Czarnota Specialist Hospital In Radom of the name Tytus Chałubiński, Adolfa Tochtermana 1, 26-610 Radom https://orcid.org/0000-0003-2783-0349
  • Michał Dobrzyński 1 Military Clinical Hospital with a Polyclinic in Lublin, Al. Racławickie 23, 20-904 Lublin https://orcid.org/0000-0002-1416-6568
  • Tomasz Skubel 1 Military Clinical Hospital with a Polyclinic in Lublin, Al. Racławickie 23, 20-904 Lublin https://orcid.org/0000-0001-7572-401X
  • Małgorzata Drozd Independent Public Clinical Hospital No. 4 in Lublin, Jaczewskiego 8, 20-954 Lublin https://orcid.org/0000-0002-0710-2451

DOI:

https://doi.org/10.12775/JEHS.2022.12.08.088

Keywords

the complement system, C5a receptor inhibitor, AVV, Avacopan

Abstract

Objective: This study aimed to evaluate the role of the complement system in a therapy of the ANCA- associated vasculitis.

 

Methods and materials: A literature search was conducted in the PubMed MEADLINE database of medical publications using the following keywords: the complement system, AVV, C5a inhibitor, avacopan

 

Results: The complement system is a crucial part of the human immune system. Its cascade is involved in the pathogenesis of many disease entities, especially those with an inflammatory response. As anaphylatoxin, this is especially true of the C5a protein. C5a receptors are distributed mainly on tissue inflammatory cells, e.g. macrophages, mast cells, and endothelial cells. Therefore a C5a receptor inhibitor may reduce the inflammatory response of the body. This mechanism is used by the Avacopan, a newly approved drug for the treatment of ANCA-associated vasculitis as the main indication. Tavneos (avacopan) was only introduced in the UE in January 2022, as the first new drug to treat AVV in over a decade.

 

Conclusion: The C5a receptor inhibitor – Avacopan might be the future of a glucocorticoids-free or glucocorticoids – low dose therapy of ANCA-associated vasculitis. As the ADVOCATE clinical trial shows, Avacopan was neither superior, nor inferior to prednisone tamper with respect to sustained remission at 26 weeks, but proved to be superior with sustaining remission at 52 weeks. All the patients received rituximab or cyclophosphamide as a form of therapy.

 

Keywords: the complement system; C5a receptor inhibitor, AVV; Avacopan

References

Liebrich W, Esser M. Complement Deficiency. Current Allergy and Clinical Immunology. 2022;30(4):276-277. doi:10.1016/b978-1-4377-1720-4.00080-7

Bardhan M, Kaushik R. Physiology, Complement Cascade. StatPearls. Published online May 8, 2022. Accessed August 18, 2022. https://www.ncbi.nlm.nih.gov/books/NBK551511/

C5a receptor antagonists - PubMed. Accessed August 20, 2022. https://pubmed.ncbi.nlm.nih.gov/10526086/

Wu KY, Cao B, Wang CX, et al. The C5a/C5aR1 Axis Contributes to the Pathogenesis of Acute Cystitis Through Enhancement of Adhesion and Colonization of Uropathogenic E. coli. Front Cell Infect Microbiol. 2022;12. doi:10.3389/FCIMB.2022.824505

Thorley J. FDA approves avacopan for ANCA-associated vasculitis. The Lancet Rheumatology. 2022;4(1):e21. doi:10.1016/s2665-9913(21)00391-x

CHMP. Tavneos INN-Avacopan. www.ema.europa.eu/contact

Fauci, Anthony S._ Hauser, Stephen L._ Jameson, J. Larry_ Kasper, Dennis L._ Longo, Dan Louis_ Loscalzo, Joseph - Harrison’s principles of internal medicine-McGraw Hill Education Medical (2015).

Lapraik C, Watts R, Bacon P, et al. BSR and BHPR guidelines for the management of adults with ANCA associated vasculitis. Rheumatology. 2007;46(10):1615-1616. doi:10.1093/RHEUMATOLOGY/KEM146A

A Phase 3 Clinical Trial of CCX168 (Avacopan) in Patients With ANCA-Associated Vasculitis - Full Text View - ClinicalTrials.gov. Accessed August 20, 2022. https://clinicaltrials.gov/ct2/show/NCT02994927?term=avacopan&cond=ANCA+Associated+Vasculitis&rank=1

Jayne DRW, Merkel PA, Schall TJ, Bekker P. Avacopan for the Treatment of ANCA-Associated Vasculitis. New England Journal of Medicine. 2021;384(7):599-609. doi:10.1056/NEJMOA2023386/SUPPL_FILE/NEJMOA2023386_DATA-SHARING.PDF

Harigai M, Takada H. Avacopan, a selective C5a receptor antagonist, for anti-neutrophil cytoplasmic antibody-associated vasculitis. Mod Rheumatol. 2022;32(3):475-483. doi:10.1093/MR/ROAB104

Markotačagalj A, Markotačagalj M, Marinovi´c BM, Bukvi´c Z, Mokos B. New and Emerging Targeted Therapies for Hidradenitis Suppurativa. International Journal of Molecular Sciences 2022, Vol 23, Page 3753. 2022;23(7):3753. doi:10.3390/IJMS23073753

Sommerfeld O, Medyukhina A, Neugebauer S, et al. Targeting Complement C5a Receptor 1 for the Treatment of Immunosuppression in Sepsis. Mol Ther. 2021;29(1):338-346. doi:10.1016/J.YMTHE.2020.09.008

Deng Y, Zheng Y, Li D, et al. Expression characteristics of interferon-stimulated genes and possible regulatory mechanisms in lupus patients using transcriptomics analyses. EBioMedicine. 2021;70:103477. doi:10.1016/J.EBIOM.2021.103477

Downloads

  • PDF

Published

2022-08-24

How to Cite

1.
RYBAK, Natalia, DUDEK, Iga, CZARNOTA, Jakub, DOBRZYŃSKI, Michał, SKUBEL, Tomasz and DROZD, Małgorzata. The complement system and its role in the treatment of ANCA-associated vasculitis. Journal of Education, Health and Sport. Online. 24 August 2022. Vol. 12, no. 8, pp. 1037-1042. [Accessed 23 May 2025]. DOI 10.12775/JEHS.2022.12.08.088.
  • ISO 690
  • ACM
  • ACS
  • APA
  • ABNT
  • Chicago
  • Harvard
  • IEEE
  • MLA
  • Turabian
  • Vancouver
Download Citation
  • Endnote/Zotero/Mendeley (RIS)
  • BibTeX

Issue

Vol. 12 No. 8 (2022)

Section

Review Articles

License

Copyright (c) 2022 Natalia Rybak, Iga Dudek, Tomasz Skubel, Michał Dobrzyński, Jakub Czarnota, Małgorzata Drozd

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

Stats

Number of views and downloads: 442
Number of citations: 0

Search

Search

Browse

  • Browse Author Index
  • Issue archive

User

User

Current Issue

  • Atom logo
  • RSS2 logo
  • RSS1 logo

Information

  • For Readers
  • For Authors
  • For Librarians

Newsletter

Subscribe Unsubscribe

Tags

Search using one of provided tags:

the complement system, C5a receptor inhibitor, AVV, Avacopan
Up

Akademicka Platforma Czasopism

Najlepsze czasopisma naukowe i akademickie w jednym miejscu

apcz.umk.pl

Partners

  • Akademia Ignatianum w Krakowie
  • Akademickie Towarzystwo Andragogiczne
  • Fundacja Copernicus na rzecz Rozwoju Badań Naukowych
  • Instytut Historii im. Tadeusza Manteuffla Polskiej Akademii Nauk
  • Instytut Kultur Śródziemnomorskich i Orientalnych PAN
  • Instytut Tomistyczny
  • Karmelitański Instytut Duchowości w Krakowie
  • Ministerstwo Kultury i Dziedzictwa Narodowego
  • Państwowa Akademia Nauk Stosowanych w Krośnie
  • Państwowa Akademia Nauk Stosowanych we Włocławku
  • Państwowa Wyższa Szkoła Zawodowa im. Stanisława Pigonia w Krośnie
  • Polska Fundacja Przemysłu Kosmicznego
  • Polskie Towarzystwo Ekonomiczne
  • Polskie Towarzystwo Ludoznawcze
  • Towarzystwo Miłośników Torunia
  • Towarzystwo Naukowe w Toruniu
  • Uniwersytet im. Adama Mickiewicza w Poznaniu
  • Uniwersytet Komisji Edukacji Narodowej w Krakowie
  • Uniwersytet Mikołaja Kopernika
  • Uniwersytet w Białymstoku
  • Uniwersytet Warszawski
  • Wojewódzka Biblioteka Publiczna - Książnica Kopernikańska
  • Wyższe Seminarium Duchowne w Pelplinie / Wydawnictwo Diecezjalne „Bernardinum" w Pelplinie

© 2021- Nicolaus Copernicus University Accessibility statement Shop