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Journal of Education, Health and Sport

The potential of cannabinoids in the treatment of lung cancer
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  • The potential of cannabinoids in the treatment of lung cancer
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  3. Vol. 12 No. 8 (2022) /
  4. Review Articles

The potential of cannabinoids in the treatment of lung cancer

Authors

  • Małgorzata Drozd Independent Public Clinical Hospital No. 4 in Lublin, Jaczewskiego 8, 20-954 Lublin https://orcid.org/0000-0002-0710-2451
  • Paweł Marzęda Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8b, 20-090 Lublin, Poland https://orcid.org/0000-0003-1697-5497
  • Jakub Czarnota Specialist Hospital In Radom of the name Tytus Chałubiński, Adolfa Tochtermana 1, 26-610 Radom https://orcid.org/0000-0003-2783-0349
  • Michał Dobrzyński 1 Military Clinical Hospital with a Polyclinic in Lublin, Al. Racławickie 23, 20-904 Lublin https://orcid.org/0000-0002-1416-6568
  • Tomasz Skubel 1 Military Clinical Hospital with a Polyclinic in Lublin, Al. Racławickie 23, 20-904 Lublin https://orcid.org/0000-0001-7572-401X
  • Iga Dudek 1 Military Clinical Hospital with a Polyclinic in Lublin, Al. Racławickie 23, 20-904 Lublin https://orcid.org/0000-0002-8101-074X
  • Natalia Rybak Independent Public Clinical Hospital No. 4 in Lublin, Jaczewskiego 8, 20-954 Lublin https://orcid.org/0000-0003-1437-7661

DOI:

https://doi.org/10.12775/JEHS.2022.12.08.094

Keywords

cannabinoids, Δ9-tetrahydrocannabinol, cannabidiol, lung cancer

Abstract

Introduction: Lung cancer is the number-one cause of death due to neoplasms worldwide. The 5-year overall survival rate is only 22%. In advanced stages, the therapeutic options are limited to chemotherapy, radiotherapy, molecularly targeted therapy and immunotherapy. Phytocannabinoids, the components of Cannabis sativa, their synthetic derivatives and endogenous cannabinoids have demonstrated anticancer activity in various common cancers - breast, prostate, colorectal and lung cancers, among others. The aim of this review was to assess the potential value of cannabinoids in the treatment of lung cancer.

State of knowledge: The majority of preclinical studies demonstrates that cannabinoids inhibit lung cancer cell viability both in vitro and in vivo. The main mechanism of anticancer  activity is the induction of apoptosis, triggered by activation of CB1, CB2 and TRPV1 receptors or independently via other pathways. Cannabinoids influence the components of the tumour microenvironment - cancer associated fibroblasts, macrophages and lymphokine-activated-killer cells. Cannabinoids alter leukocyte infiltration into anti-cancer proportions, inhibit expression of EGFR and PAI-1 and increase the expression of TIMP-1. As a result they induce cytotoxicity, decrease proliferation, migration and invasive potential of lung cancer cells, suppress angiogenesis and metastasis forming. Patients with advanced lung cancer may also benefit from analgesic, antiemetic and appetite improving properties of cannabinoids.

Summary: Cannabinoids can be a supplementary agent in systemic anticancer therapeutic regimen in the future. The exact mechanisms of action, specific doses in anticancer treatment, routes of administration and interactions with other anticancer drugs has yet to be determined. Thus the clinical studies on cannabinoids in lung cancer should be performed in the future.

References

Dyba T, Randi G, Bray F, et al. The European cancer burden in 2020: Incidence and mortality estimates for 40 countries and 25 major cancers. Eur J Cancer. 2021;157:308-347. doi:10.1016/j.ejca.2021.07.039

Cancer Facts & Figures 2022. https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/annual-cancer-facts-and-figures/2022/2022-cancer-facts-and-figures.pdf. Accessed 15 Aug 2022.

Krzakowski M, Jassem J, Antczak A, et al. Thoracic neoplasms. Oncol Clin Pract. 2022;18(1):1-39. doi:10.5603/OCP.2021.0022

Boyero L, Sánchez-Gastaldo A, Alonso M, Noguera-Uclés JF, Molina-Pinelo S, Bernabé-Caro R. Primary and Acquired Resistance to Immunotherapy in Lung Cancer: Unveiling the Mechanisms Underlying of Immune Checkpoint Blockade Therapy. Cancers. 2020;12(12):3729. doi:10.3390/cancers12123729

Pacher P, Mechoulam R. Is lipid signaling through cannabinoid 2 receptors part of a protective system? Prog Lipid Res. 2011;50(2):193-211. doi:10.1016/j.plipres.2011.01.001

Tomko AM, Whynot EG, Ellis LD, Dupré DJ. Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis. Cancers. 2020;12(7):1985. doi:10.3390/cancers12071985

Boyacıoğlu Ö, Bilgiç E, Varan C, et al. ACPA decreases non-small cell lung cancer line growth through Akt/PI3K and JNK pathways in vitro. Cell Death Dis. 2021;12(1):56. doi:10.1038/s41419-020-03274-3

Turner SE, Williams CM, Iversen L, Whalley BJ. Molecular Pharmacology of Phytocannabinoids. Prog Chem Org Nat Prod. 2017;103:61-101. doi:10.1007/978-3-319-45541-9_3

Milian L, Mata M, Alcacer J, et al. Cannabinoid receptor expression in non-small cell lung cancer. Effectiveness of tetrahydrocannabinol and cannabidiol inhibiting cell proliferation and epithelial-mesenchymal transition in vitro. PloS One. 2020;15(2):e0228909. doi:10.1371/journal.pone.0228909

Staiano RI, Loffredo S, Borriello F, et al. Human lung-resident macrophages express CB1 and CB2 receptors whose activation inhibits the release of angiogenic and lymphangiogenic factors. J Leukoc Biol. 2016;99(4):531-540. doi:10.1189/jlb.3HI1214-584R

Müller L, Radtke A, Decker J, Koch M, Belge G. The Synthetic Cannabinoid WIN 55,212-2 Elicits Death in Human Cancer Cell Lines. Anticancer Res. 2017;37(11):6341-6345.

Hurley JD, Akers AT, Friedman JR, Nolan NA, Brown KC, Dasgupta P. Non-pungent long chain capsaicin-analogs arvanil and olvanil display better anti-invasive activity than capsaicin in human small cell lung cancers. Cell Adhes Migr. 2017;11(1):80-97. doi:10.1080/19336918.2016.1187368

Sulé-Suso J, Watson NA, van Pittius DG, Jegannathen A. Striking lung cancer response to self-administration of cannabidiol: A case report and literature review. SAGE Open Med Case Rep. 2019;7:2050313X19832160. doi:10.1177/2050313X19832160

Mangal N, Erridge S, Habib N, Sadanandam A, Reebye V, Sodergren MH. Cannabinoids in the landscape of cancer. J Cancer Res Clin Oncol. 2021;147(9):2507-2534. doi:10.1007/s00432-021-03710-7

Hall W, Degenhardt L. The adverse health effects of chronic cannabis use. Drug Test Anal. 2014;6(1-2):39-45. doi:10.1002/dta.1506

Ghasemiesfe M, Barrow B, Leonard S, Keyhani S, Korenstein D. Association Between Marijuana Use and Risk of Cancer. JAMA Netw Open. 2019;2(11):e1916318. doi:10.1001/jamanetworkopen.2019.16318

Hosami F, Manayi A, Salimi V, et al. The pro-apoptosis effects of Echinacea purpurea and Cannabis sativa extracts in human lung cancer cells through caspase-dependent pathway. BMC Complement Med Ther. 2021;21:37. doi:10.1186/s12906-021-03204-6

Hamad H, Olsen BB. Cannabidiol Induces Cell Death in Human Lung Cancer Cells and Cancer Stem Cells. Pharmaceuticals. 2021;14(11):1169. doi:10.3390/ph14111169

Afrin F, Chi M, Eamens AL, et al. Can Hemp Help? Low-THC Cannabis and Non-THC Cannabinoids for the Treatment of Cancer. Cancers. 2020;12(4):1033. doi:10.3390/cancers12041033

Martín-Banderas L, Muñoz-Rubio I, Prados J, et al. In vitro and in vivo evaluation of Δ9-tetrahidrocannabinol/PLGA nanoparticles for cancer chemotherapy. Int J Pharm. 2015;487(1-2):205-212. doi:10.1016/j.ijpharm.2015.04.054

Milián L, Monleón-Guinot I, Sancho-Tello M, et. al. In Vitro Effect of ∆9-Tetrahydrocannabinol and Cannabidiol on Cancer-Associated Fibroblasts Isolated from Lung Cancer. Int J Mol Sci. 2022;23;6766. https://doi.org/10.3390/ijms23126766

Ravi J, Wani NA, Elbaz M, Nasser MW, Ganju RK. Cannabinoid receptor-2 agonist inhibits macrophage induced EMT in non-small cell lung cancer by downregulation of EGFR pathway. Mol Carcinog. 2016;55(12):2063-2076. doi:10.1002/mc.22451

Ramer R, Rohde A, Merkord J, Rohde H, Hinz B. Decrease of plasminogen activator inhibitor-1 may contribute to the anti-invasive action of cannabidiol on human lung cancer cells. Pharm Res. 2010;27(10):2162-2174. doi:10.1007/s11095-010-0219-2

Ramer R, Fischer S, Haustein M, Manda K, Hinz B. Cannabinoids inhibit angiogenic capacities of endothelial cells via release of tissue inhibitor of matrix metalloproteinases-1 from lung cancer cells. Biochem Pharmacol. 2014;91(2):202-216. doi:10.1016/j.bcp.2014.06.017

Winkler K, Ramer R, Dithmer S, Ivanov I, Merkord J, Hinz B. Fatty acid amide hydrolase inhibitors confer anti-invasive and antimetastatic effects on lung cancer cells. Oncotarget. 2016;7(12):15047-15064. doi:10.18632/oncotarget.7592

Prüser JL, Ramer R, Wittig F, Ivanov I, Merkord J, Hinz B. The Monoacylglycerol Lipase Inhibitor JZL184 Inhibits Lung Cancer Cell Invasion and Metastasis via the CB1 Cannabinoid Receptor. Mol Cancer Ther. 2021;20(5):787-802. doi:10.1158/1535-7163.MCT-20-0589

Kienzl M, Hasenoehrl C, Maitz K, et al. Monoacylglycerol lipase deficiency in the tumor microenvironment slows tumor growth in non-small cell lung cancer. Oncoimmunology. 10(1):1965319. doi:10.1080/2162402X.2021.1965319

Haustein M, Ramer R, Linnebacher M, Manda K, Hinz B. Cannabinoids increase lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1. Biochem Pharmacol. 2014;92(2):312-325. doi:10.1016/j.bcp.2014.07.014

Mücke M, Weier M, Carter C, Copeland J, Degenhardt L, Cuhls H, Radbruch L, Häuser W, Conrad R. Systematic review and meta-analysis of cannabinoids in palliative medicine. J Cachexia Sarcopenia Muscle. 2018;9(2):220-234. doi: 10.1002/jcsm.12273.

Taha T, Meiri D, Talhamy S, Wollner M, Peer A, Bar‐Sela G. Cannabis Impacts Tumor Response Rate to Nivolumab in Patients with Advanced Malignancies. The Oncologist. 2019;24(4):549-554. doi:10.1634/theoncologist.2018-0383

Schussel V, Kenzo L, Santos A, et al. Cannabinoids for nausea and vomiting related to chemotherapy: Overview of systematic reviews. Phytother Res. 2018;32(4):567-576. doi:10.1002/ptr.5975

Parker LA, Rock EM, Limebeer CL. Regulation of nausea and vomiting by cannabinoids. Br J Pharmacol. 2011;163(7):1411-1422. doi:10.1111/j.1476-5381.2010.01176.x

Turcott JG, Del Rocío Guillen Núñez M, Flores-Estrada D, et al. The effect of nabilone on appetite, nutritional status, and quality of life in lung cancer patients: a randomized, double-blind clinical trial. Support Care Cancer Off J Multinatl Assoc Support Care Cancer. 2018;26(9):3029-3038. doi:10.1007/s00520-018-4154-9

Meng H, Dai T, Hanlon JG, Downar J, Alibhai SMH, Clarke H. Cannabis and cannabinoids in cancer pain management. Curr Opin Support Palliat Care. 2020;14(2):87-93. doi:10.1097/SPC.0000000000000493

Curry ZA, Wilkerson JL, Bagdas D, et al. Monoacylglycerol Lipase Inhibitors Reverse Paclitaxel-Induced Nociceptive Behavior and Proinflammatory Markers in a Mouse Model of Chemotherapy-Induced Neuropathy. J Pharmacol Exp Ther. 2018;366(1):169-183. doi:10.1124/jpet.117.245704

Xu S, Ma H, Bo Y, Shao M. The oncogenic role of CB2 in the progression of non-small-cell lung cancer. Biomed Pharmacother Biomedecine Pharmacother. 2019;117:109080. doi:10.1016/j.biopha.2019.109080

Yasmin-Karim S, Moreau M, Mueller R, et al. Enhancing the Therapeutic Efficacy of Cancer Treatment With Cannabinoids. Front Oncol. 2018;8:114. doi:10.3389/fonc.2018.00114

Ngwa W, Kumar R, Moreau M, Dabney R, Herman A. Nanoparticle Drones to Target Lung Cancer with Radiosensitizers and Cannabinoids. Front Oncol. 2017;7:208. doi:10.3389/fonc.2017.00208

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Published

2022-08-25

How to Cite

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DROZD, Małgorzata, MARZĘDA, Paweł, CZARNOTA, Jakub, DOBRZYŃSKI, Michał, SKUBEL, Tomasz, DUDEK, Iga & RYBAK, Natalia. The potential of cannabinoids in the treatment of lung cancer. Journal of Education, Health and Sport [online]. 25 August 2022, T. 12, nr 8, s. 1100–1110. [accessed 25.3.2023]. DOI 10.12775/JEHS.2022.12.08.094.
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Vol. 12 No. 8 (2022)

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Review Articles

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Copyright (c) 2022 Małgorzata Drozd, Paweł Marzęda, Jakub Czarnota, Michał Dobrzyński, Tomasz Skubel, Iga Dudek, Natalia Rybak

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