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Journal of Education, Health and Sport

HA (hyaluronic acid) fillers in aesthetic medicine - the most common complications
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  • HA (hyaluronic acid) fillers in aesthetic medicine - the most common complications
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HA (hyaluronic acid) fillers in aesthetic medicine - the most common complications

Authors

  • Monika Szwed Provincial Specialist Hospital of the name Stefan Cardinal Wyszyński, Aleja Kraśnicka 100, 20-718 Lublin https://orcid.org/0000-0002-5711-2172
  • Weronika Szwed School of Medicine, University of Warmia and Mazury in Olsztyn, Aleja Warszawska 30, 11-082 Olsztyn https://orcid.org/0000-0001-9546-7970
  • Jakub Szwed Department of Urology, Independent Public Healthcare Center in Lubartów, Cicha 14, 21-100 Lubartów https://orcid.org/0000-0003-4480-4265
  • Nadia Miga Medical University of Lublin, Aleje Racławickie 1, 20-059 Lublin https://orcid.org/0000-0002-0551-6159

DOI:

https://doi.org/10.12775/JEHS.2022.12.08.073

Keywords

hyaluronic acid, HA, aesthetic medicine, filler complication

Abstract

Introduction and purpose

Hyaluronic acid (HA) is a polysaccharide consisting of the disaccharide units of glucuronic acid and N-acetylglucosamine. The age-related changes in the different anatomical layers of the face can be treated with hyaluronic acid fillers. Knowing the predictable aging changes of the face is crucial as this guides the optimum filler choice. HA is currently the most common used filler worldwide. 

The aim of the study is to discuss the most common complications following aesthetic medicine treatments with the use of hyaluronic acid.

 

Description of the state of knowledge

Filling soft tissues with hyaluronic acid is a popular procedure in the field of aesthetic medicine for patients who want non-invasive rejuvenation. Among the numerous fillers, those with hyaluronic acid (HA) have many advantages: HA is easy to use and its effect is reversible. HA fillers are considered safe, although there may be complications such as: allergic reactions, infections, granulomas, nodules, tyndall effect, ecchymosis and skin necrosis. Many complications with the HA filler are correctable, for example: too little formulation, over-correctionand, asymmetry. Hyaluronic acid fillers are examples of reversible dermal fillers as they can be removed with hyaluronidase.

 

Summary

Avoiding complications is a top priority and must start with a thorough understanding of the anatomy followed by a precise injection technique. The ability to recognize complications and manage protocols will allow for their effective treatment.

References

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Kapoor KM, Saputra DI, Porter CE, Colucci L, Stone C, Brenninkmeijer EEA, Sloane J, Sayed K, Winaya KK, Bertossi D. Treating Aging Changes of Facial Anatomical Layers with Hyaluronic Acid Fillers. Clin Cosmet Investig Dermatol. 2021; 14: 1105–1118. doi: 10.2147/CCID.S294812

Zielke H, Wolber L, Wiest L, Rzany B. Risk profiles of different injectable fillers: results from the injectable filler safety study (IFS study). Dermatol Surg 2008;34:326e35

Kim DW, Yoon ES, Ji YH, Park SH, Lee BI, Dhong ES. Vascular complications of hyaluronic acid fillers and the role of hyaluronidase in management. Journal of Plastic, Reconstructive & Aesthetic Surgery (2011) 64, 1590e1595

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DeLorenzi C. Complications of Injectable Fillers, Part I. Aesthetic Surgery Journal 33(4) 561–575 2013. DOI: 10.1177/1090820X13484492

Tezel A, Fredrickson GH. The science of hyaluronic acid dermal fillers. Journal of Cosmetic and Laser Therapy. 2008; 10: 35–42

Singh K, Nooreyezdan S. Nonvascular Complications of Injectable Fillers—Prevention and Management. Indian J Plast Surg. 2020 Dec; 53(3): 335–343. doi: 10.1055/s-0040-1721872

Kablik J, Monheit GD, Yu L, Chang G, et al. Comparative physical properties of hyaluronic acid dermal fillers. Dermatol Surg 2009; 35(Suppl 1):302–12.

Lee W, Hwang SG, Oh W, Kim CY, Lee JL, Yang EJ. Practical Guidelines for Hyaluronic Acid Soft-Tissue Filler Use in Facial Rejuvenation. Dermatol Surg 2019;00:1–9 DOI: 10.1097/DSS.0000000000001858

DeLorenzi C. Complications of Injectable Fillers, Part 2: Vascular Complications. Aesthetic Surgery Journal 2014, Vol. 34(4) 584–600

Cohen JL. Understanding, avoiding, and managing dermal filler complications. Dermatol Surg 2008;34(Suppl. 1):S92e9.

Kim DW, Yoon ES, Ji YH, Park SH, Lee BI, Dhong ES. Vascular complications of hyaluronic acid fillers and the role of hyaluronidase in management. J Plast Reconstr Aesthetic Surg. 2011;64:1590-1595.

Kapoor KM, Kapoor P, Heydenrych I, Bertossi D. Vision Loss Associated with Hyaluronic Acid Fillers: A Systematic Review of Literature. Aesth Plast Surg 2019 https://doi.org/10.1007/s00266-019-01562-8

Rzany B, Becker-Wegerich P, Bachmann F, Erdmann R, Wollina U. Hyaluronidase in the correction of hyaluronic acid-based fillers: a review and a recommendation for use. J Cosmet Dermatol. 2009;8(04):317–323

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de Maio M, Swift A, Signorini M, Fagien S. Facial Assessment and Injection Guide for Botulinum Toxin and Injectable Hyaluronic Acid Fillers: Focus on the Upper Face. Plastic and Reconstructive Surgery 2017 Volume 140, Number 2 Botox Injection Guide for Upper Face.

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Published

2022-08-22

How to Cite

1.
SZWED, Monika, SZWED, Weronika, SZWED, Jakub and MIGA, Nadia. HA (hyaluronic acid) fillers in aesthetic medicine - the most common complications. Journal of Education, Health and Sport. Online. 22 August 2022. Vol. 12, no. 8, pp. 722-729. [Accessed 2 July 2025]. DOI 10.12775/JEHS.2022.12.08.073.
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Issue

Vol. 12 No. 8 (2022)

Section

Review Articles

License

Copyright (c) 2022 Monika Szwed, Weronika Szwed, Jakub Szwed, Nadia Miga

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

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