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Journal of Education, Health and Sport

The treatment of polycystic ovary syndrome and systematization of knowledge - literature review
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The treatment of polycystic ovary syndrome and systematization of knowledge - literature review

Authors

  • Katarzyna Cyboran Medical Faculty, Institute of Medical Sciences, Collegium Medicum, Oleska Street 48, 45-052 Opole
  • Alicja Płaczek Medical Faculty, University of Rzeszow, Pigonia Street 6, 35-310 Rzeszow
  • Dominik Machaj Faculty of Medicine, Medical University of Lublin, Chodźki 19, 20-093 Lublin
  • Agnieszka Siedlak Medical Faculty, Institute of Medical Sciences, Collegium Medicum, Oleska Street 48, 45-052 Opole
  • Kamil Pondel Medical Faculty, University of Rzeszow, Pigonia Street 6, 35-310 Rzeszow

DOI:

https://doi.org/10.12775/JEHS.2022.12.08.085

Keywords

PCOS treatment, lifestyle change, diet, metformin, clomiphene citrate, Hormone Replacement Therapy

Abstract

Polycystic ovary syndrome (PCOS) is a known disease among endocrinologists and gynecologists. The aforementioned disease entity affects up to six to twelve percent of women of reproductive age. [1] In 2017, the incidence among women of childbearing age was 82.44 per 100,000 population. A decade ago, it was 1.45% lower.[2] PCOS is a disease in which we have abnormal hormone levels. The result may be a problem with regular menstruation, problems with becoming pregnant, acne or excessive body weight. [3] Most often, patients arediagnosed only when complications occur. It is closely related to asignificant reduction in living standards. There are problems such as hair loss, acne and infertility.

References

Skiba MA, Islam RM, Bell RJ, Davis SR. Understanding Variation in Prevalence Estimates of Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis. Hum Reprod Update (2018) 24:694–709.

Liu, J. et al. Measuring the global disease burden of polycystic ovary syndrome in 194 countries: Global Burden of Disease Study 2017. Hum Reprod. 36(4), 1108–1119 (2021).

Bani Mohammad, M. & Majdi, S. A. Polycystic ovary syndrome (PCOS), diagnostic criteria, and AMH. Asian Pac. J. Cancer Prev. 18(1), 17–21 (2017).

In this literature review, we present current treatments for polycystic ovary syndrome based on the latest guidelines. The area of our interest is the use of metformin in the treatment of hyperinsulinemia and after-effects, clomiphene citrate to stimulate ovulation, alleviation of symptoms PCOS with hormone replacement therapy, behavioral changes and diet treatment.

Yuanyuan Gu12, Guannan Zhou23, Fangyue Zhou4, Qiongwei Wu1, Chengbin Ma1, Yi Zhang1, Jingxin Ding23, Keqin Hua23 ; Life Modifications and PCOS: Old Story But New Tales ; Front Endocrinol (Lausanne). 2022 Apr 13;13:808898. doi: 10.3389/fendo.2022.808898. eCollection 2022.

https://emedicine.medscape.com/article/404754-overview

International evidence-based guideline for the assessment and management of polycystic ovary syndrome 2018; Helena Teede, Marie Misso, Michael Costello, Anuja Dokras, Joop Laven, Lisa Moran, Terhi Piltonen and Robert Norman on behalf of the International PCOS Network in collaboration with funding, partner and collaborating organisations, 2018: 18-36

Krzysztof Katulski, Adam Czyżyk, Błażej Męczekalski; Hiperandrogenizacja i zespół policystycznych jajników; Ginekologia Grzegorz H. Bręborowicz; Wydawnictwo Lekarskie, Warszawa 2020, Wydanie III - 4 dodruk Warszawa 2021 - 196-202

Agnieszka Drosdzol-Cop, Agata Sidło-Stawowy, Dominika Sajdak, Violetta Skrzypulec-Plinta; Diagnosing polycystic ovary syndrome in adolescent girl; Ginekol Pol. 2014, 85, 145-148

Radomski D. Orzechowska A., Barcz E. ; Współczesne koncepcje etiopatogenezy zespołu policystycznych jajników; Ginekol Pol. 2007; 78, 393-399

Richard S Legro, M.D.Department of Obstetrics and Gynecology, Penn State College of Medicine, 500 University Drive,Hershey, PA, USA; Evaluation and Treatment of Polycystic Ovary Syndrome; Feingold KR, Anawalt B, Boyce A, et al., editors. South Dartmouth (MA): MDText.com, Inc.; 2000-.

Tracy Williams1, Rami Mortada2, Samuel Porter; Diagnosis and Treatment of Polycystic Ovary Syndrome; Am Fam Physician 2016 Jul 15;94(2):106-13.

Gao T, Wu L, Chang F, Cao G. Low circulating ghrelin levels in women with polycystic ovary syndrome: a systematic review and meta-analysis. Endocr J. 2016;63(1):93–100

Moran LJ, Noakes M, Clifton PM, Wittert G, Tomlinson L, Galletly C, Luscombe N, Norman RJ. Grelina i miary sytości są zmienione w zespole policystycznych jajników, ale nie mają na nie wpływu skład diety. Asia Pac J Clin Nutr. 2003;12:S52.

Lin T, Li S, Xu H, Zhou H, Feng R, Liu W, Sun Y, Ma J. Wydzielanie hormonów żołądkowo-jelitowych u kobiet z zespołem policystycznych jajników: badanie obserwacyjne. Reprodukcja szumu. 2015;30(11):2639–44.

Aydin K, Arusoglu G, Koksal G, Cinar N, Aksoy DY, Yildiz BO. Glukagonopodobny peptyd 1 na czczo i po posiłku oraz doustna antykoncepcja w zespole policystycznych jajników. Clin Endocrinol. 2014;81(4):588–92.

Magdalena Smyka1, Barbara Grzechocinska1, Miroslaw Wielgos1; The role of lifestyle changes in the treatment of polycystic ovary syndrome;

Neuro Endocrinol Lett. 2018 Feb;38(8):521-527.

Krysiak R, Okopieƒ B, Gdula-Dymek A, [et al.]. Update on the management of polycystic ovary syndrome. Pharmacol Rep. 2006, 58, 614-25

Ehrmann D. Polycystic ovary syndrome. N Engl J Med. 2005, 352, 1223-1236.

Fleming R, Hopkinson Z, Wallace A, [et al.]. Ovarian function and metabolic factors in women with oligomenorrhea treated with metformin in a randomized double blind placebo-controlled trial. J Clin Endocrinol Metab. 2002, 87, 569-574.

Nestler J, Jakubowicz D, Evans W, [et al.]. Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome. N Engl J Med. 1998, 338, 1876-1880.

Vandermolen D, Ratts V, Evans W, [et al.]. Metformin increases the ovulatory rate and pregnancy rate from clomiphene citrate in patients with polycystic ovary syndrome who are resistant to clomiphene citrate alone. Fertil Steril. 2001, 75, 310-315

Sujata Kar and Smriti Sanchita; Clomiphene citrate, metformin or a combination of both as the first line ovulation induction drug for Asian Indian women with polycystic ovarian syndrome: A randomized controlled trial; J Hum Reprod Sci. 2015 Oct-Dec; 8(4): 197–201.

Ahmed Badawy1 and Abubaker Elnashar2 ; Treatment options for polycystic ovary syndrome ; Int J Womens Health. 2011; 3: 25–35.

Azziz R. UpToDate. Clinical Reference Library; 2006. Use of combination oral contraceptives in the treatment of hyperandrogenism and hirsutism. Available from: http://www.uptodate.com. Accessed Dec 2, 2010. [Google Scholar]

Ehrmann DA. Polycystic ovary syndrome. N Engl J Med. 2005;352(12):1223–1236. [PubMed] [Google Scholar]

Tracy Williams1, Rami Mortada2, Samuel Porter1; Diagnosis and Treatment of Polycystic Ovary Syndrome; Am Fam Physician. 2016 Jul 15;94(2):106-13.

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Published

2022-08-24

How to Cite

1.
CYBORAN, Katarzyna, PŁACZEK, Alicja, MACHAJ, Dominik, SIEDLAK, Agnieszka and PONDEL, Kamil. The treatment of polycystic ovary syndrome and systematization of knowledge - literature review. Journal of Education, Health and Sport. Online. 24 August 2022. Vol. 12, no. 8, pp. 1012-1020. [Accessed 19 November 2025]. DOI 10.12775/JEHS.2022.12.08.085.
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Vol. 12 No. 8 (2022)

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Review Articles

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Copyright (c) 2022 Katarzyna Cyboran, Alicja Płaczek, Dominik Machaj, Agnieszka Siedlak, Kamil Pondel

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

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