Vitamin D toxicity – causes, symptoms and diagnosis
DOI:
https://doi.org/10.12775/JEHS.2022.12.08.080Keywords
vitamin d, toxicityAbstract
Abstract:
Introduction and purpose: This review aims to analyze causes, symptoms and diagnosis of overdosing vitamin D resulting in vitamin D toxicity (VDT).
Material and method: This paper was based on medical articles collected in Pubmed from 2008 to 2021 year. The research has been done by looking through keywords such as “vitamin D” “toxicity”.
Results: The review of studies showed that manifestation of VDT is mainly associated with hypercalcemia and its course can range from asymptomatic to life-threatening, including death. We also draw attention to inappropriate use and widespread of vitamin D products.
Conclusion: There is a high demand for medical health workers to advise patients on possible effects of inappropriate use of vitamin D products and its toxicity. Medical practitioners should be attentive to quickly identify VDT.
References
Rizzoli R. Vitamin D supplementation: upper limit for safety revisited? Aging Clin Exp Res. 2021 Jan;33(1):19-24. doi: 10.1007/s40520-020-01678-x. Epub 2020 Aug 28. PMID: 32857334; PMCID: PMC7897606.
Taylor PN, Davies JS. A review of the growing risk of vitamin D toxicity from inappropriate practice. Br J Clin Pharmacol. 2018 Jun;84(6):1121-1127. doi: 10.1111/bcp.13573. Epub 2018 Apr 16. PMID: 29498758; PMCID: PMC5980613.
Çağlar A, Tuğçe Çağlar H. Vitamin D intoxication due to misuse: 5-year experience. Arch Pediatr. 2021 Apr;28(3):222-225. doi: 10.1016/j.arcped.2020.12.009. Epub 2021 Jan 19. PMID: 33483193.
Pfotenhauer KM, Shubrook JH. Vitamin D Deficiency, Its Role in Health and Disease, and Current Supplementation Recommendations. J Am Osteopath Assoc. 2017 May 1;117(5):301-305. doi: 10.7556/jaoa.2017.055. PMID: 28459478.
Marcinowska-Suchowierska E, Kupisz-Urbańska M, Łukaszkiewicz J, Płudowski P, Jones G. Vitamin D Toxicity-A Clinical Perspective. Front Endocrinol (Lausanne). 2018 Sep 20;9:550. doi: 10.3389/fendo.2018.00550. PMID: 30294301; PMCID: PMC6158375.
Heaney RP. Vitamin D in health and disease. Clin J Am Soc Nephrol. 2008 Sep;3(5):1535-41. doi: 10.2215/CJN.01160308. Epub 2008 Jun 4. PMID: 18525006; PMCID: PMC4571146.
Lim K, Thadhani R. Vitamin D Toxicity. J Bras Nefrol. 2020 Apr 3;42(2):238-244. doi: 10.1590/2175-8239-JBN-2019-0192. PMID: 32255467; PMCID: PMC7427646.
Fraser DR. Vitamin D toxicity related to its physiological and unphysiological supply. Trends Endocrinol Metab. 2021 Nov;32(11):929-940. doi: 10.1016/j.tem.2021.08.006. Epub 2021 Sep 10. PMID: 34518055.
Vogiatzi MG, Jacobson-Dickman E, DeBoer MD; Drugs, and Therapeutics Committee of The Pediatric Endocrine Society. Vitamin D supplementation and risk of toxicity in pediatrics: a review of current literature. J Clin Endocrinol Metab. 2014 Apr;99(4):1132-41. doi: 10.1210/jc.2013-3655. Epub 2014 Jan 23. PMID: 24456284.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Katarzyna Kosz, Klaudia Remjasz, Aleksandra Kuchnicka, Julia Kuchnicka, Natalia Zarankiewicz, Martyna Zielińska, Klaudia Sapuła, Jakub Aleksandrowicz, Wojciech Siedlecki
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 656
Number of citations: 0
