Vitamin D toxicity – causes, symptoms and diagnosis
DOI:
https://doi.org/10.12775/JEHS.2022.12.08.080Keywords
vitamin d, toxicityAbstract
Abstract:
Introduction and purpose: This review aims to analyze causes, symptoms and diagnosis of overdosing vitamin D resulting in vitamin D toxicity (VDT).
Material and method: This paper was based on medical articles collected in Pubmed from 2008 to 2021 year. The research has been done by looking through keywords such as “vitamin D” “toxicity”.
Results: The review of studies showed that manifestation of VDT is mainly associated with hypercalcemia and its course can range from asymptomatic to life-threatening, including death. We also draw attention to inappropriate use and widespread of vitamin D products.
Conclusion: There is a high demand for medical health workers to advise patients on possible effects of inappropriate use of vitamin D products and its toxicity. Medical practitioners should be attentive to quickly identify VDT.
References
Rizzoli R. Vitamin D supplementation: upper limit for safety revisited? Aging Clin Exp Res. 2021 Jan;33(1):19-24. doi: 10.1007/s40520-020-01678-x. Epub 2020 Aug 28. PMID: 32857334; PMCID: PMC7897606.
Taylor PN, Davies JS. A review of the growing risk of vitamin D toxicity from inappropriate practice. Br J Clin Pharmacol. 2018 Jun;84(6):1121-1127. doi: 10.1111/bcp.13573. Epub 2018 Apr 16. PMID: 29498758; PMCID: PMC5980613.
Çağlar A, Tuğçe Çağlar H. Vitamin D intoxication due to misuse: 5-year experience. Arch Pediatr. 2021 Apr;28(3):222-225. doi: 10.1016/j.arcped.2020.12.009. Epub 2021 Jan 19. PMID: 33483193.
Pfotenhauer KM, Shubrook JH. Vitamin D Deficiency, Its Role in Health and Disease, and Current Supplementation Recommendations. J Am Osteopath Assoc. 2017 May 1;117(5):301-305. doi: 10.7556/jaoa.2017.055. PMID: 28459478.
Marcinowska-Suchowierska E, Kupisz-Urbańska M, Łukaszkiewicz J, Płudowski P, Jones G. Vitamin D Toxicity-A Clinical Perspective. Front Endocrinol (Lausanne). 2018 Sep 20;9:550. doi: 10.3389/fendo.2018.00550. PMID: 30294301; PMCID: PMC6158375.
Heaney RP. Vitamin D in health and disease. Clin J Am Soc Nephrol. 2008 Sep;3(5):1535-41. doi: 10.2215/CJN.01160308. Epub 2008 Jun 4. PMID: 18525006; PMCID: PMC4571146.
Lim K, Thadhani R. Vitamin D Toxicity. J Bras Nefrol. 2020 Apr 3;42(2):238-244. doi: 10.1590/2175-8239-JBN-2019-0192. PMID: 32255467; PMCID: PMC7427646.
Fraser DR. Vitamin D toxicity related to its physiological and unphysiological supply. Trends Endocrinol Metab. 2021 Nov;32(11):929-940. doi: 10.1016/j.tem.2021.08.006. Epub 2021 Sep 10. PMID: 34518055.
Vogiatzi MG, Jacobson-Dickman E, DeBoer MD; Drugs, and Therapeutics Committee of The Pediatric Endocrine Society. Vitamin D supplementation and risk of toxicity in pediatrics: a review of current literature. J Clin Endocrinol Metab. 2014 Apr;99(4):1132-41. doi: 10.1210/jc.2013-3655. Epub 2014 Jan 23. PMID: 24456284.
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Copyright (c) 2022 Katarzyna Kosz, Klaudia Remjasz, Aleksandra Kuchnicka, Julia Kuchnicka, Natalia Zarankiewicz, Martyna Zielińska, Klaudia Sapuła, Jakub Aleksandrowicz, Wojciech Siedlecki
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